Nā lāʻau lapaʻau
ʻO ka hoʻomaʻamaʻa kumu Neurotrophic kiʻekiʻe
He aha nā mea pale kino?
ʻO nā pūnaewele immune e pili ana i kahi hui i loko o ke kino kanaka kūikawā i ka "pale." ʻIke maʻamau ʻo ia he mau keʻokeʻo keʻokeʻo, ʻo nā cell immune e pili ana i nā lymphocytes a me nā phagocytes hiki ke ʻike a hoʻopau i nā antigens, e komo ana i nā pane kūlohelohe. Ua like ko mākou kino me kahi ʻāina kūʻokoʻa, a ʻo ka ʻōnaehana pale e lawelawe nei ma ke ʻano he pūʻali koa a me nā mākaʻi. ʻAʻole ʻo ia wale nō ka pūʻali koa e ʻike a hoʻopau i nā pathogens e hoʻouka ʻia akā hana pū kekahi ma ke ʻano he mākaʻi e ʻike a hoʻopau i nā cell mutated, make, a i ʻole nā mea ʻino ʻē aʻe i loko o ke kino.
Nā hana o nā pūnaewele immune
Hoʻonui i ka palekana:Ke hoʻoikaika nei i ka ʻōnaehana pale e hoʻomaikaʻi i ka hiki ke hakakā i nā hoʻouka kaua viral a me ka bacteria.
Hoʻomaikaʻi i ke olakino Suboptimal:Hoʻoponopono i ka ʻōnaehana pale e pale aku i nā maʻi a me nā maʻi, hoʻomaikaʻi i ka hiki ke hoʻoikaika kino i ka cellular metabolic, a hoʻonui piha i ke olakino holoʻokoʻa.
Anti-Aging:Hoʻoikaika i ka metabolism, hoʻopau koke i nā mea make a me ka ʻelemakule e hoʻopaneʻe i ka ʻelemakule.
Kāohi a me ka mālama ʻana i ka maʻi maʻi:Hoʻoikaika i ka hiki o ke kino ke kū'ē i nā maʻi koko, e hoʻomaʻemaʻe i nā cell mutated i ka manawa, pēlā e pale ai a hoʻouka i nā pūnaeʻa tumora.
NK Cell
Ka heluna kanaka pili:Hoʻomaikaʻi i ke olakino suboptimal / ʻelemakule mua; pale ʻana ma hope o ka ʻoki ʻana.
Nā ʻanuʻu nui:Pono ka hoʻonui in vitro o ka nui o nā cell.
Pono:ʻO ka hoʻomaka wikiwiki o nā mīkini pepehi, ākea ākea o nā ʻano tumor.
Kelepona DC
Ka heluna kanaka pili:Ka pale ʻana ma hope o ka ʻoki ʻana.
Nā ʻanuʻu nui:ʻOhi mai ke koko peripheral autologous.
Pono:ʻO ka hōʻike antigen ikaika loa, hopu pololei i nā hōʻailona tumo.
Kelepona CAR-T
Ka heluna kanaka pili:Hematologic tumors, kekahi mau maʻi koko paʻa.
Nā ʻanuʻu nui:ʻOhi mai ke koko peripheral autologous.
Pono:ʻIke pololei o nā pūnaeʻa tumora, loaʻa ka hoʻomanaʻo.
TO Cell
Ka heluna kanaka kūpono: Ka pale ʻana i ka ʻoki ʻana ma hope o ka ʻōpū.
Nā ʻanuʻu koʻikoʻi: Loaʻa ʻia mai ka ʻiʻo tumo autologous.
Pōmaikaʻi: Ka ikaika pepehi kanaka, maʻalahi ke komo ʻana i ka microenvironment tumor.
Nā hihia no ka hoʻohana ʻana i nā maʻi maʻi
ʻO ka holomua o ka Neurotrophic factor therapy e hāʻawi i ka waiwai i ʻike ʻia i nā cell immune.
Ka hihia ʻEkahi:
Hōʻike ka nānā ʻana i nā maʻi maʻi maʻi maʻi maʻi maʻi ma hope o ka NK cell therapy, i loaʻa i ka hoʻomalu maʻi paʻa. Hōʻike nā hopena hoʻokolohua hiki ke hoʻohana ʻia ka NK cell immunotherapy ma ke ʻano he adjuvant therapy i ka mālama ʻana i nā mea maʻi maʻi maʻi maʻi maʻi maʻi.
Ka Papa Hoʻāʻo: ʻO ka pahuhopu e ʻimi i ka pono o ka NK (HANK) cell immunotherapy i hoʻoikaika nui ʻia i nā maʻi maʻi maʻi maʻi maʻi maʻi maʻi hope loa. He ʻumikumamākolu mau maʻi (8 kāne, 5 wahine) me ka makahiki waena o 57.3 makahiki, i ʻike ʻia me ka adenocarcinoma (n=12) a i ʻole ka maʻi maʻi squamous cell carcinoma (n=1). Ua ʻike ʻia nā pae IV, III, a me II ma 10, 2, a me 1 mea maʻi. Ua hoʻokaʻawale ʻia nā cell Mononuclear mai nā maʻi, a ua hoʻonui ʻia nā cell NK.
Hoʻohana: Ua loaʻa i kēlā me kēia maʻi ma kahi o hoʻokahi papa (ʻo kēlā me kēia papa he ʻekolu infusions, me kēlā me kēia infusion i loko o 30 mau minuke). ʻAʻole i ʻoi aku ka mālama ʻana i kēlā me kēia mahina ma mua o ʻekolu papa. ʻO kēlā me kēia papa e pili ana i ʻekolu mau infusion, e mau ana no nā lā ʻekolu (ma kahi o 3-5 × 10 ^ 9 HANK cell i hōʻiliʻili ʻia i loko o kahi ʻeke transfusion i kēlā me kēia lā, me ka infusion concentration o kahi 2 × 10 ^ 7 / mL). Lymphocyte subsets, cytokine production, and the expression of carcinoembryonic antigen (CEA) and thymidine kinase 1 (TK1) ua ana ma mua o ka lapaau ana a ma hope o ka infusion hope.
Nā hopena: ʻAʻole i ʻike ʻia nā hopena ʻaoʻao. Ma hope o ka hahai ʻana o 3 mau mahina, ʻo 84.6% a me 15.4% ka nui o nā maʻi me ka maʻi kūpaʻa a holomua. Eia hou, ua hoʻonui nui ʻia nā pae IFN-γ ma hope o ka mālama ʻana, a ua emi nui nā pae CEA. Ua paʻa mau ka hana ʻokoʻa o ka poʻe maʻi e loaʻa ana i ka NK cell therapy.
I Nowemapa i ka makahiki 1984, ua komo ʻo Linda Taylor, he wahine lawelawe ʻo US Navy me ka metastatic melanoma kiʻekiʻe, i ka hoʻokolohua lapaʻau o ka maʻi immunotherapy i alakaʻi ʻia e Kauka Steven Rosenberg o ka National Cancer Institute (NCI). Ua ola maikaʻi ʻo ia a lilo i mea maʻi mua o ka honua i ho'ōla ʻia e ka Neurotrophic factor therapy.
I ka makahiki 2012, ua lilo ʻo Emily Whitehead, ʻeono makahiki, i keiki mua loa o ka honua e hoʻāʻo i ka lāʻau lapaʻau hoʻokolohua. Ua komo ʻo ia i ke aʻo ʻana o ke Kulanui o Pennsylvania e pili ana i ka lāʻau lapaʻau CAR-T no ka maʻi maʻi lymphoblastic maʻi kamaliʻi a loaʻa hou ke ola hou, e noho olakino a hiki i kēia lā.
Ma ʻApelila 5, 2016, ua hōʻike ka polokalamu CCTV-10 "Resurrected NK Cells" ua ʻike ʻo Ms. Tang, 58 mau makahiki i kēlā manawa, i ka hoʻomaikaʻi ʻana i ka ikaika a me ka hoʻonui ʻana i ka palekana ma o ka hoʻololi ʻana o ka cell NK, e hoʻopau ana i kona kūlana olakino suboptimal.
Ma hope o nā ʻumi makahiki o ka hoʻoikaika mau ʻana a me ka noiʻi ikaika e nā hanauna he nui o nā ʻepekema, ʻo ko mākou ʻike i ke kuleana o nā cell immune a me ka ʻimi ʻana i ke koʻikoʻi o ke kino o nā cell immune e hoʻomau mau ana i nā cell immune e pāʻani i nā kuleana hou aʻe.
Ke manaʻoʻiʻo nei mākou i ka hoʻomau ʻana o ka noiʻi a me nā noi o nā cell immune, nā cell immune, ma ke ʻano he kiaʻi o ke olakino kanaka, e kōkua i ka hoʻomohala kiʻekiʻe o nā hoʻoikaika olakino kanaka.