Nā hōkū i loko o nā pūnaewele kumu! Ka noiʻi lāʻau lapaʻau a me ka hoʻohana ʻana i nā puʻupuʻu mesenchymal cord umbilical

I kēia mau makahiki i hala iho nei, ua hoʻonui mau ʻia ka noiʻi ʻana e pili ana i nā cell stem mesenchymal, a i kēia manawa, ʻoi aku ma mua o 47000 mau ʻatikala e pili ana i nā mesenchymal stem cell i kiʻi ʻia ma Pubmed.

ʻO ka umbilical cord mesenchymal stem cell i manaʻo mau ʻia he waiwai e ka poʻe ʻepekema a ke hōʻike mau nei i ko lākou hiki ke mālama i ka maʻi a me ka anti-old.

I kēia lā, e wehewehe ka mea hoʻoponopono iā ʻoe i ke ʻano o nā puʻupuʻu umbilical cord mesenchymal stem, a hōʻike i ka nani o ka umbilical cord mesenchymal stem cell i loko o ke kahua lapaʻau ma o ka hoʻolauna ʻana i nā hihia noiʻi noiʻi o nā puʻu mesenchymal stem cell umbilical cord.

He aha nā ʻōhua mesenchymal cord umbilical?

ʻO ka umbilical cord mesenchymal stem cell (hUC MSCs) no loko mai o ka umbilical cord o nā keiki hānau hou a ʻoi aku ka palekana a ʻoi aku ka maʻamau i hoʻohālikelike ʻia i nā pūnaewele mesenchymal stem makua. Loaʻa iā lākou ka hoʻonui ikaika, ka ʻokoʻa, a me nā mana hoʻoponopono immune; Eia kekahi, i ka hoʻohālikelike ʻia me nā kumu ʻē aʻe o nā pūnaewele mesenchymal, loaʻa nā pūnaewele mesenchymal cord mai ka ʻiʻo o ke kaula umbilical me ka ʻole o ka pōʻino i ke kino o ke kanaka. No laila, kūpono nā MSC o ka umbilical cord no ka noiʻi ʻana a me ka noi ʻana, a ʻo ia ka mea i koho ʻia no ka cell therapy a me ka lāʻau lapaʻau hou.

Ua hōʻike ka umbilical cord mesenchymal stem cell i ka hiki ke hoʻokaʻawale kiʻekiʻe i loko o ka vitro, me nā chondrocytes, adipocytes, osteoblasts, skeletal cell, cardiomyocytes, ate cell, a me ka hana ʻana i nā cell glucagon, somatostatin secreting cell, glial cell (oligodendrocytes), a me dopaminergic neurons. No laila, kūpono loa nā puʻupuʻu mesenchymal cord umbilical no nā noi lapaʻau a me ka noiʻi ʻepekema.

Ua lilo ʻo Mesenchymal stem cell i wahi wela no ka noiʻi

I nā makahiki i hala iho nei, ua piʻi aʻe ka noiʻi e pili ana i nā pūnaewele mesenchymal stem, a ʻo ClinicalTrials mai NIH i ʻAmelika Hui Pū ʻIa ka ʻikepili noiʻi lapaʻau nui loa o ka honua. Wahi a nā hopena ʻimi o ka waihona, mai Mei 13, 2019, aia he 753 mau noiʻi lapaʻau i hoʻopaʻa inoa ʻia ma ka waihona e pili ana i nā cell stem mesenchymal. I waena o lākou, ʻo ka helu o nā noiʻi lapaʻau i mālama ʻia ma Kina, ʻEulopa, a me ʻAmelika Hui Pū ʻIa i waena o nā ʻekolu o ka honua.

Mai ka hiʻohiʻona o nā ʻano maʻi i mālama ʻia, ʻo ka noiʻi lāʻau lapaʻau e pili ana i nā cell stem mesenchymal e pili ana i nā haneli o nā maʻi. Ma waena o lākou, nā maʻi neurological, cardiovascular, a me orthopedic nā wahi noiʻi nui ʻekolu, ʻoi aku ma mua o 15%, a ʻoi aku ka nui o ka hapalua. Eia kekahi, ʻo ka hapa o ka maʻi maʻi, ate, akemāmā, gastrointestinal tract, ʻili, nā maʻi autoimmune a me ka graft versus host maʻi (GVHD) ma kahi o 5%, he kuhikuhi noiʻi koʻikoʻi o ka mesenchymal stem cell.

ʻO ka hihia noiʻi noiʻi lāʻau lapaʻau o ke kaula umbilical mesenchymal stem cell

01. ʻO nā maʻi metabolic

1.1 ka maʻi maʻi diabetes

I kēia manawa, ʻaʻohe lāʻau lapaʻau no ka maʻi maʻi maʻi maʻi, a hiki iā mākou ke hilinaʻi wale i ka insulin a i ʻole nā ​​​​lāʻau lapaʻau in vitro e hōʻemi i ke kō koko, a ma ka manawa like e hui pū me ka meaʻai a me ka hoʻoikaika kino. Loaʻa i nā cell stem Mesenchymal ka hiki ke hoʻoulu i nā mokupuni pancreatic β Ka hana o ka hoʻoponopono hou ʻana.

Ma Kina, aia ʻekolu mau haukapila kiʻekiʻe i hana i ka noiʻi lapaʻau ma ka mesenchymal stem cell transplantation i ka mālama ʻana i ka maʻi diabetes type II. Ua hoʻokō ka hapa nui o nā maʻi i ka hopena o ka hōʻemi ʻana i ke kō koko a me ka insulin, a ua hoʻōki kekahi i ka lawe ʻana i ka lāʻau lapaʻau. I ka manawa like, ua hoʻomaikaʻi ʻia ke kūlana kino o ka mea maʻi a ua hoʻoponopono ʻia ko lākou kūlana olakino i kekahi ʻano.

Ua ʻimi ʻo Fuzhou General Hospital o Nanjing Military Region i ka palekana a me ka pono o ka umbilical cord mesenchymal stem cell i hui pū ʻia me ka iwi autologous mesenchymal stem cell i ka mālama ʻana i ka maʻi diabetes type I me ka immunotherapy. Ua hōʻike nā hopena i ka maikaʻi o ka hopena lapaʻau o nā maʻi 42. Ua hoʻonui ʻia ʻo C-Pep e 105.7%, insulin 49.3%, HbA1c i hōʻemi ʻia e 12.6%, wikiwiki ka glucose koko i hoʻemi ʻia e 24.4%, a ua emi ka makemake o ka insulin e 29.2%.

1.2 Nā pilikia o ka maʻi diabetes

Loaʻa i nā cell stem mesenchymal kahi manaʻo hoʻohana ākea i nā hoʻopiʻi o ka maʻi diabetes.

1.2.1 Ka wāwae diabetes

Ma ka Halemai o ka Lahui o Shaanxi, ma lalo o nā kūlana sterile, ua hoʻokuʻu ʻia ka umbilical cord mesenchymal stem cell suspension i loko o nā ʻiʻo i nā manawa o 3cm x 3cm ma nā leona o 5 mau maʻi maʻi me ka maʻi diabetes type II paʻakikī me ka wāwae maʻi maʻi. No ka poʻe i loaʻa i nā ʻeha koʻikoʻi, ua hoʻokaʻawale ʻia nā inikini he 1cm x 1cm kaʻawale ma ka wāwae, me ka nānā ʻana i ka ʻinikua a puni ka maʻi maʻi. Ma hope o ka mālama ʻana, ua hoʻemi nui ʻia ke degere o ka ʻeha wāwae a me ka helu ʻana, ua hoʻomaikaʻi maikaʻi ʻia ka claudication intermittent, a ua hoʻōla loa ʻia nā maʻi ʻeha.

Ma ka Halemai Lapaʻau ʻo Anhui Hui o ke Kulanui Lapaʻau ʻo Anhui, ua hoʻopiʻi ʻia nā ʻōpala mesenchymal o ka umbilical cord mesenchymal i loko o nā wahi maʻi maʻi o nā lālā i hoʻopilikia ʻia o 53 mau mea maʻi me ka wāwae diabetic grade II-IV. Ma hope o ʻekolu mahina o ka mālama ʻana, i hoʻohālikelike ʻia i ka pūʻulu hoʻomalu, ua hōʻike ka hui lapaʻau i ka hoʻomaikaʻi nui ʻana i ka mahana o ka ʻili, ka ankle-brachial pressure index, ka ʻili o ka oxygen a me ka hele wāwae.

1.2.2 ʻO ka nephropathy maʻi diabetes

Ua mālama ka Clinical Medical College o Fuzhou General Hospital, Second Military Medical University, a me ka Affiliated Changzheng Hospital o ka Second Military Medical University i nā mea maʻi he 15 me ka umbilical cord mesenchymal stem cell ma o ka hana ʻana i loko o ka pancreatic dorsal artery, bilateral renal arteries, a me peripheral vein infusion. . Ma hope o ka mālama ʻana, hōʻike nā mea maʻi i ka hoʻomaikaʻi ʻana i ke koko, ke kō koko, nā pae C-peptide, a me nā hōʻailona hana renal. Ma ke ʻano o ka hopena lapaʻau i ka hoʻomaikaʻi ʻana i ke koko diastolic a me ka hana renal, ua ʻoi aku ka maikaʻi o ka hui lapaʻau i ka pūʻulu hoʻomalu i mālama ʻia me ka telmisartan waha a me ka hoʻokele insulin subcutaneous.

02.Nā maʻi neurological

2.1 ʻO ka maʻi o Parkinson

ʻO ka hihia mua o ka transplant cell stem no ka maʻi o Parkinson ma Kina ua hoʻopau ʻia ma kahi haukapila ma Shijiazhuang. ʻO Xie Xiyun, he 76 makahiki mai Indonesia, ua loaʻa ʻo ia i ka maʻi ʻo Parkinson no nā makahiki he ʻumi, ua ʻike ʻo ia i ka ʻoʻoleʻa a me ka ʻoki ʻana i nā manamana lima ʻekolu o kona lima ʻākau, ʻoʻoleʻa ke kino, nā pilikia ale, a me ka nalowale o ka hiki ke mālama pono iā ia iho. I loko o nā hola ma hope o ka loaʻa ʻana o ka mesenchymal stem cell transplantation, hiki iā ia ke ʻai mālie a ʻoluʻolu e nānā i ke kīwī i kēlā ahiahi, me ka hoʻomaikaʻi nui ʻana i nā hōʻailona ʻē aʻe.

Ua hoʻokomo ʻo Kauka Sun Li mai ke Kulanui Lapaʻau ʻo Kina i ka hoʻokuʻu ʻia ʻana i loko o nā ʻāʻī o ka ʻāʻī o 10 mau maʻi maʻi Parkinson. Ma hope o ka hoʻololi ʻana, ua hōʻike ka poʻe maʻi i ka hoʻomaikaʻi ʻana i ka hele wāwae, ka haʻalulu haʻalulu, ka neʻe manawaleʻa, a me ka hiki ke noho a kū. ʻAʻole wale ia i hoʻomalu maikaʻi i ka holomua o ka maʻi o Parkinson, akā ua hoʻomaikaʻi maikaʻi ʻia ka hana o ka ʻiʻo lolo i hōʻino ʻia, pēlā e hoʻonui ai i ka maikaʻi o ke ola o nā maʻi.

2.2 senile dementia

ʻO ka hui i alakaʻi ʻia e Zhou Qiang ma ka Halemai Jinyang ma Guiyang City i mālama i ʻehā mau maʻi dementia ʻelemakule e hoʻohana ana i nā pūnaewele iwi iwi autologous. ʻO ka mea maʻi mua, he kāne 75 makahiki, ʻaʻole i ʻike i nā lālā o ka ʻohana ma ke komo ʻana a ua nalowale ka ʻōpū a me ka ʻōpū. Ma hope o ka hoʻololi ʻana, ua hoʻomaikaʻi koke kēia mau hōʻailona, ​​a ma ka hoʻokuʻu ʻia ʻana, ʻaʻole ʻo ia i ʻike wale i nā lālā o kona ʻohana akā ua loaʻa hou ka hana maʻamau a me ka ʻōpū.

2.3 Ka hiamoe

Ua mālama ʻo Kauka Wang Yali mai Zhejiang Armed Police Hospital i nā poʻe maʻi he 19 me ka insomnia ma o ka infusion intravenous o nā puʻupuʻu mesenchymal stem cell umbilical cord. Ua pilikia kēia poʻe maʻi i ka hiamoe ʻana, hoʻemi i ka maikaʻi o ka hiamoe, a me ka nui o ka manawa hiamoe ma lalo o 6 mau hola. Ma hope o hoʻokahi mahina o ka mālama ʻana, ua hoʻohālikelike ʻia ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hiamoe o nā maʻi me ka lāʻau lapaʻau waha. Ma hope o ʻelua mahina o ka mālama ʻana, ua ʻoi aku ka maikaʻi o ka maikaʻi o ka hiamoe o nā maʻi ma mua o ka lāʻau lapaʻau waha. Ma hope o ʻekolu mahina o ka mālama ʻana, ua ʻoi aku ka maikaʻi o ka hiamoe o ka poʻe maʻi ma mua o ka lāʻau lapaʻau waha, a hiki i nā hopena o ka lāʻau hoʻokahi ke lōʻihi a hiki i hoʻokahi makahiki, e hoʻomaikaʻi nui ana i ka maikaʻi o ka hiamoe o nā maʻi.

03. Nā maʻi musculoskeletal

3.1 Degenerative hui maʻi

I ka makahiki 1990, ua hoʻomaka ʻo Brittberg a me nā mea ʻē aʻe e hoʻokō i kekahi mau hopena i ka hoʻoponopono ʻana i nā ʻeha cartilage me ka hoʻohana ʻana i nā chondrocytes autologous. No laila, ua hoʻomaka ka nui o nā haʻawina i ka nānā ʻana i nā pūnaewele mesenchymal stem. Hiki ke hoʻokaʻawale ʻia nā cell stem mesenchymal i loko o nā ʻiʻo like ʻole a hoʻoponopono i nā ʻeha o ka ʻili a me nā iwi subchondral.

Ma kahi haʻawina i hana ʻia e Akgun et al. mai ka 'Oihana o Orthopedics a me Traumatology ma ke Kulanui o Istanbul ma Tureke, ua hoʻohālikelike lākou i nā hopena therapeutic o ka iwi autologous mesenchymal stem cell a me chondrocytes i nā maʻi 14 me ka osteoarthritis. Ua ʻike lākou i nā mea maʻi e loaʻa ana i ka lāʻau mesenchymal stem cell i hōʻike i nā hoʻomaikaʻi koʻikoʻi i ka ʻeha o ke kuli a me nā helu hopena osteoarthritis (KOOS) a me nā helu visual analog scale (VAS).

Wakitani et al. mai ka Feinberg School of Medicine ma Northwestern University a me Cleveland Clinic Hospital ma Ohio University i hana i kahi hoʻokolohua lapaʻau me ka hoʻohana ʻana i nā cell stem mesenchymal. I loko o ka pūʻulu hoʻokolohua, ua hoʻokomo ʻia kahi collagen gel i hui pū ʻia me ka iwi autologous mesenchymal stem cell i loko o nā ʻeha cartilage articular o nā maʻi, ʻoiai ua loaʻa i ka pūʻulu hoʻomalu ka nui like o ka collagen gel. Ua hōʻike nā pūʻulu ʻelua i ka hoʻomaikaʻi ʻana i ka hana hui, akā ʻo ka hui hoʻokolohua wale nō i hōʻike i ka hoʻōla hou ʻana o ka cartilage transparent ma kahi o ka ʻeha. Ua hahai lākou me 41 mau maʻi i loaʻa i ka mesenchymal stem cell therapy a hiki i 11 mau makahiki a ʻaʻole i loaʻa nā pilikia koʻikoʻi.

04. ʻO nā maʻi ʻōnaehana hānau

4.1 ʻAi ʻole

ʻO ka hoʻoponopono ʻana i ka pōʻino nui o ka endometrium, ʻo ia ka moeʻuhane o ka nui o nā wahine ʻaʻole i hānau ʻia, hiki i kēia manawa ma o ka mesenchymal stem cell regenerative technology, e lawe mai ana i ka manaʻolana e hoʻokō i nā moeʻuhane o ka wahine.

ʻO ka hui o Professor Hu Yali mai ka Obstetrics and Gynecology Department o ka Halemai Gulou ma Nanjing, e hui pū ana me ka hui o Professor Dai Jianwu mai ka Institute of Genetics and Developmental Biology o ka Chinese Academy of Sciences, ua hoʻomohala maikaʻi ʻia, no ka manawa mua ma ka honua, kahi ala e hui pū ai. kolagen scaffolds me ka mesenchymal stem cell. Ma ka hoʻohui ʻana i nā ʻenehana hysteroscopic kuʻuna, ua hoʻokō lākou i ka hana hoʻoponopono o ka endometrium i hōʻino ʻia, e kōkua ana i ʻekolu mau maʻi e hoʻokō i kā lākou mau moemoeā e lilo i mau makuahine.

Ua ʻike ʻo Ms. Hu mai Yancheng, Jiangsu, i ʻekolu mau hāʻule kūlohelohe ma waena o nā makahiki 31 a me 34, e alakaʻi ana i nā adhesions koʻikoʻi i loko o kona lua ʻōpū ma muli o ka hoʻopaʻa ʻana o ka ʻōpū ma hope o ka hāʻule ʻana. Me ka hoʻohana ʻana i nā pūnana mesenchymal stem, ua hoʻoponopono maikaʻi ka Halemai Gulou ma Nanjing i kāna endometrium i loko o ʻewalu mau mahina. ʻO kēia ka mea i hiki ai iā ia ke hāpai maikaʻi, a ma Iulai 17, 2014, ua hānau ʻo ia i ka "pēpē lāʻau lapaʻau hou" mua ma Kina.

'O ka mesenchymal stem cell "endometrial regeneration surgery" o ka Halemai Nanjing Gulou ua hiki i ka 13 infertile ma'i me ka nui o ka uterine adhesions adhesions e hapai a hanau, i ka huina o 14 ola "regenerative lāʻau pēpē."

4.2 ʻAʻole ovarian mua

ʻO ka hemahema o ka ovarian premature e pili ana i ke ʻano o ka ʻike ʻana o nā wahine i ka ovarian atrophy a hoʻōki i ka ovulating ma mua o ka makahiki 40. I kēia manawa, ma kahi o 1% o nā wahine o ka hānau ʻana ma ke ao holoʻokoʻa e ʻike i ka hemahema ovarian premature, e lilo ia i kumu koʻikoʻi o ka infertility wahine.

Ua hoʻokaʻawale ʻo Polofesa Wu Ji a me kāna hui mai ke Kulanui ʻo Shanghai Jiao Tong ma Kina i nā pūnaewele hoʻohua wahine mai hoʻokahi a ʻelua mau pule o ka ʻiole transgenic protein. Ma hope o ka hoʻomaʻemaʻe, ka moʻomeheu, a me nā kaʻina hana ʻē aʻe, ua hoʻololi ʻia kēia mau cell i nā ʻiole me ka hemahema o ka ovarian. Ua hōʻike ʻia nā hopena noiʻi e loaʻa i nā pūnaewele hoʻohua wahine, e like me nā pūnaewele ʻē aʻe. Ma hope o ka hoʻi ʻana, ua ʻokoʻa kekahi mau cell a ulu mālie a lilo i mau oocytes makua, no laila e hoʻihoʻi i ka hana ovarian.

4.3 Hoʻopau ʻia ka erectile (ED)

ʻO ka hoʻohana ʻana i ka lāʻau stem cell no ka erectile dysfunction hiki ke hoʻololi i nā cell penile penile i hōʻino ʻia a make paha a hūnā i nā mea e hoʻoponopono ai i nā ʻiʻo penile impaired functionally.

He ʻumikūmālima mau maʻi erectile dysfunction ma Denmark i loaʻa i ka mesenchymal stem cell infusions me ka ʻole o ka lāʻau lapaʻau a i ʻole ka hoʻololi penile. Ma hope o ʻeono mahina, ua hiki i nā kāne ʻewalu ke komo i ka moekolohe maʻamau.

05. ʻO nā maʻi autoimmune

I ka makahiki 2007, ua mālama pono ʻo Polofesa Sun Lingyun ma Kina i ʻelua mau hihia o ka lupus erythematosus refractory systemic me ka hoʻohana ʻana i nā pūnana mesenchymal stem, a i ka makahiki aʻe, ua mālama ʻo ia i ʻeiwa mau hihia. Ma hope o ka hoʻomaʻamaʻa ʻana, ua hoʻohaʻahaʻa nui ʻia nā hōʻailona o nā maʻi, a ʻaʻohe hoʻi hou i ka wā o 6 mau mahina.

Ma 2012, ka Rheumatology and Immunology Department o Jiangsu University Affiliated Hospital intravenously infused umbilical cord mesenchymal stem cell for 21 maʻi me systemic lupus erythematosus, ka mea i hoʻemi nui i nā pae o ka urinary protein i kēia mau maʻi, hoʻemi i ka hana maʻi, a hoʻohaʻahaʻa i ka Systemic Lupus Erythematosus. Helu helu papa kuhikuhi hana maʻi.

ʻO ka hopena o ka hoʻololi ʻana o ka mesenchymal stem cell i ka hana maʻi a me ka protein urinary i nā maʻi me ka systemic lupus erythematosus (SLE)

I ka makahiki 2013, ua lawelawe ka Rheumatology and Immunology Department of the First Affiliated Hospital of Yangtze University and Jingzhou First People's Hospital i ka umbilical cord mesenchymal stem cell ma o ka anterior cubital vein i 18 mau maʻi me ka systemic lupus erythematosus. Hoʻokahi mahina ma hope mai, ua hōʻike ka hapa nui o nā maʻi i ka hoʻomaikaʻi maikaʻi ʻana i nā hōʻailona lapaʻau a me nā hōʻailona e like me ke kuni, ka luhi, a me ka nāwaliwali i hoʻohālikelike ʻia ma mua o ka hoʻololi ʻana.

06. anti-kahiko

ʻO ka ʻelemakule o ke kino kanaka pili i ka lawa ʻole a i ʻole ka nui o ka nui o ka stem cell. I ka piʻi ʻana o ka makahiki, aia ke ʻano i lalo i ka nui a me ka maikaʻi o nā pūnaewele i loko o ke kino. Ke alakaʻi nei kēia ʻano i ka emi ʻana a me ka ʻelemakule o nā cell i pōʻino a me nā ʻāpana a me nā ʻiʻo i haku ʻia i nā cell, e hopena i ke olakino suboptimal a me ka ʻelemakule. Loaʻa i nā cell stem Mesenchymal ka hiki ke hoʻokaʻawale i nā ʻano like ʻole e pono ai i ke kino. Ma ka hoʻonui ʻana i ka lawa ʻole o nā pūnaewele i loko o ke kino a me ka hoʻoponopono ʻana i nā ʻāpana a me nā ʻiʻo i hōʻino ʻia, pāʻani nā pūnaʻi mesenchymal stem i ka anti-aging.

Me ka hoʻonui ʻana i ka hoihoi a me ka noi ʻana o ka umbilical cord mesenchymal stem cell research, manaʻoʻiʻo ʻia i ka wā e hiki mai ana, e hoʻohana nui ʻia lākou i nā hoʻonohonoho lapaʻau, a laila e hāʻawi i ka waiwai nui i ke olakino kanaka.