Kev kho mob
Advanced Neurotrophic factor therapy
Lub cev tiv thaiv kab mob yog dab tsi?
Lub cev tiv thaiv kab mob xa mus rau ib pawg hauv tib neeg lub cev tshwj xeeb hauv "kev tiv thaiv." Feem ntau hu ua cov qe ntshav dawb, lub cev tiv thaiv kab mob muaj xws li ntau yam lymphocytes thiab phagocytes uas tuaj yeem paub thiab tshem tawm cov antigens, koom nrog hauv kev tiv thaiv kab mob. Peb lub cev zoo ib yam li lub tebchaws ywj pheej, thiab lub cev tiv thaiv kab mob ua haujlwm raws li peb cov tub rog thiab tub ceev xwm. Nws tsis tsuas yog ua raws li cov tub rog txhawm rau txheeb xyuas thiab tshem tawm cov kab mob nkag mus tab sis tseem ua haujlwm raws li tub ceev xwm kom paub txog thiab tshem tawm cov hloov pauv, cov hlwb tuag, lossis lwm yam khoom tsis zoo hauv lub cev.
Kev ua haujlwm ntawm lub cev tiv thaiv kab mob
Txhim khu kev tiv thaiv:Ua kom lub cev tiv thaiv kab mob los txhim kho lub peev xwm tiv thaiv kab mob thiab kab mob invasion.
Txhim kho Suboptimal Health:Kev tswj hwm lub cev tiv thaiv kab mob tiv thaiv kab mob thiab kab mob, txhim kho cellular metabolic muaj peev xwm, thiab ua kom muaj kev noj qab haus huv tag nrho.
Anti-Aging:Txhawb cov metabolism, sai tshem tawm cov hlwb tuag thiab laus kom ncua kev laus.
Kev Tiv Thaiv thiab Kev Kho Mob Cancer:Ua kom lub cev muaj peev xwm tiv thaiv qog nqaij hlav, tshem tawm cov hlwb hloov pauv raws sijhawm, yog li tiv thaiv thiab tawm tsam cov qog hlwb.
NK Cell
Muaj Peev Xwm Muaj Peev Xwm:Txhim kho kev noj qab haus huv zoo tshaj plaws / kev laus thaum ntxov; kev tiv thaiv kab mob tom qab phais.
Cov kauj ruam tseem ceeb:Yuav tsum tau nyob rau hauv vitro expansion ntawm ntau lub hlwb.
Qhov zoo:Kev pib sai ntawm kev tua cov txheej txheem, dav spectrum ntawm qog hom.
DC Cell
Muaj Peev Xwm Muaj Peev Xwm:Kev tiv thaiv kab mob tom qab phais.
Cov kauj ruam tseem ceeb:Sau los ntawm autologous peripheral ntshav.
Qhov zoo:Kev nthuav qhia antigen muaj zog tshaj plaws, kev ntes cov qog nqaij hlav.
CAR-T Cell
Muaj Peev Xwm Muaj Peev Xwm:Hematological qog, qee cov qog nqaij hlav.
Cov kauj ruam tseem ceeb:Sau los ntawm autologous peripheral ntshav.
Qhov zoo:Kev txheeb xyuas meej ntawm cov qog hlwb, muaj kev nco.
RAU Cell
Muaj Peev Xwm Muaj Peev Xwm: Kev tiv thaiv kev phais mob tom qab phais.
Cov kauj ruam tseem ceeb: Tau txais los ntawm cov ntaub so ntswg autologous.
Qhov zoo: Muaj peev xwm tua muaj zog, nkag tau yooj yim ntawm cov qog microenvironment.
Daim ntawv thov Case ntawm Immune Cells
Txoj kev vam meej ntawm Neurotrophic factor therapy ua rau pom muaj txiaj ntsig ntau dua rau cov hlwb tiv thaiv kab mob.
Case Ib:
Cov kev soj ntsuam soj ntsuam pom tau tias cov neeg mob qog nqaij hlav qog nqaij hlav lig, tom qab NK cell kho, ua tiav cov kab mob ruaj khov. Cov txiaj ntsig kev sim ua pov thawj tias NK cell immunotherapy tuaj yeem siv los ua kev kho mob ntxiv rau hauv kev kho mob rau cov neeg mob qog nqaij hlav lig.
Kev sim keeb kwm yav dhau: Lub hom phiaj yog txhawm rau tshawb nrhiav qhov ua tau zoo ntawm kev ua haujlwm siab NK (HANK) cell immunotherapy hauv cov neeg mob qog nqaij hlav lig. Kaum peb tus neeg mob (8 tus txiv neej, 5 tus poj niam) uas muaj hnub nyoog nruab nrab ntawm 57.3 xyoo, kuaj pom tias muaj adenocarcinoma (n=12) lossis squamous cell carcinoma (n=1), suav nrog. Qib IV, III, thiab II raug kuaj pom hauv 10, 2, thiab 1 tus neeg mob, raws li. Mononuclear hlwb raug cais tawm ntawm cov neeg mob, thiab NK hlwb tau nthuav dav.
Kev Siv: Txhua tus neeg mob tau txais tsawg kawg ib chav kawm (txhua chav kawm suav nrog peb qhov kev txhaj tshuaj, nrog rau txhua qhov kev txhaj tshuaj ntev li 30 feeb). Cov kev kho mob txhua hli tsis tshaj peb chav kawm. Txhua chav kawm koom nrog peb qhov kev txhaj tshuaj sib law liag, kav ntev li peb hnub (kwv yees li 3-5 × 10^9 HANK hlwb tau muab sau rau hauv ib lub hnab ntim ntshav txhua hnub, nrog rau qhov infusion concentration ntawm txog 2 × 10^7 / mL). Lymphocyte subsets, cytokine ntau lawm, thiab kev qhia ntawm carcinoembryonic antigen (CEA) thiab thymidine kinase 1 (TK1) raug ntsuas ua ntej kev kho mob thiab tom qab qhov kawg ntawm kev txhaj tshuaj.
Cov txiaj ntsig: Tsis muaj kev phiv tshwm sim. Tom qab kev soj ntsuam 3 lub hlis, qhov feem pua ntawm cov neeg mob uas muaj tus kab mob ruaj khov thiab kev loj hlob yog 84.6% thiab 15.4%, feem. Tsis tas li ntawd, IFN-γ qib tau nce ntxiv tom qab kev kho mob, thiab CEA qib tau txo qis. Tag nrho lub cev tiv thaiv kab mob ntawm cov neeg mob tau txais kev kho mob NK cell nyob ruaj khov.
Thaum lub Kaum Ib Hlis 1984, Linda Taylor, ib tug poj niam US Navy servicewoman nrog cov kab mob metastatic melanoma, tau koom nrog kev sim tshuaj kho mob qog noj ntshav coj los ntawm Dr. Steven Rosenberg ntawm National Cancer Institute (NCI). Nws tau ua tiav txoj sia nyob thiab dhau los ua tus neeg mob thawj zaug hauv ntiaj teb kho los ntawm Neurotrophic factor therapy.
Xyoo 2012, 6-xyoo-laus Emily Whitehead tau dhau los ua thawj tus menyuam hauv ntiaj teb tau txais kev sim tshuaj ntawm tes. Nws tau koom nrog University of Pennsylvania txoj kev tshawb fawb txog CAR-T kev kho mob rau menyuam yaus mob qog ntshav qog ntshav ntshav thiab tau txais lub neej tshiab, ua neej nyob zoo rau hnub no.
Thaum Lub Plaub Hlis 5, 2016, CCTV-10 qhov kev pab cuam "Resurrected NK Cells" tau tshaj tawm tias Ms. Tang, 58 xyoo thaum lub sijhawm, tau ntsib kev txhim kho tseem ceeb thiab txhim kho kev tiv thaiv los ntawm NK cell, tshem tawm nws txoj kev noj qab haus huv tsis zoo.
Tom qab xyoo dhau los ntawm kev siv zog tsis tu ncua thiab kev tshawb fawb los ntawm ntau tiam neeg ntawm cov kws tshawb fawb, peb txoj kev nkag siab ntawm lub luag haujlwm ntawm lub cev tiv thaiv kab mob thiab kev tshawb nrhiav qhov tseem ceeb ntawm cov tshuaj tiv thaiv kab mob tau txuas ntxiv ua rau lub cev tiv thaiv kab mob ua si ntau lub luag haujlwm.
Peb ntseeg hais tias raws li kev tshawb fawb thiab kev siv ntawm lub cev tiv thaiv kab mob txuas ntxiv mus, lub cev tiv thaiv kab mob, raws li cov neeg saib xyuas kev noj qab haus huv ntawm tib neeg, yuav ua rau muaj kev txhim kho zoo ntawm tib neeg kev noj qab haus huv.