Cov hnub qub hauv cov qia hlwb! Kev tshawb fawb soj ntsuam thiab kev siv ntawm cov hlab ntsha mesenchymal qia hlwb

Nyob rau hauv xyoo tas los no, kev tshawb fawb ntawm mesenchymal qia hlwb tau nce mus tas li, thiab txog tam sim no, ntau tshaj 47000 kab lus hais txog mesenchymal qia hlwb tau rov qab los ntawm Pubmed.

Umbilical qaum mesenchymal qia hlwb yeej ib txwm raug suav hais tias yog cov khoom muaj nqis los ntawm cov kws tshawb fawb thiab niaj hnub ua kom pom lawv lub peev xwm kho kab mob thiab tiv thaiv kev laus.

Niaj hnub no, tus editor yuav piav qhia rau koj txog dab tsi umbilical qaum mesenchymal qia hlwb yog dab tsi, thiab ua kom pom lub ntsej muag ntawm txoj hlab ntaws mesenchymal qia hlwb hauv kev kho mob los ntawm kev qhia txog kev tshawb fawb soj ntsuam cov ntaub ntawv ntawm cov kab mob umbilical mesenchymal qia hlwb.

Dab tsi yog umbilical qaum mesenchymal qia hlwb?

Umbilical cord mesenchymal qia hlwb (hUC MSCs) yog los ntawm txoj hlab ntaws ntawm cov menyuam yug tshiab thiab muaj kev nyab xeeb dua qub thiab qub dua piv rau cov neeg laus mesenchymal qia hlwb. Lawv muaj kev loj hlob muaj zog, sib txawv, thiab kev tiv thaiv kab mob muaj peev xwm; Tsis tas li ntawd, piv rau lwm qhov chaw ntawm mesenchymal qia hlwb, cov hlab ntsha mesenchymal qia hlwb tau txais los ntawm cov ntaub so ntswg umbilical uas tsis muaj kev puas tsuaj rau tib neeg lub cev. Yog li ntawd, umbilical cord MSCs yog qhov tsim nyog rau kev tshawb fawb thiab kev siv tshuaj kho mob, thiab yog qhov kev xaiv zoo tshaj plaws rau kev kho ntawm tes thiab tshuaj kho dua tshiab.

Umbilical qaum mesenchymal qia hlwb tau pom muaj peev xwm sib txawv hauv vitro, suav nrog chondrocytes, adipocytes, osteoblasts, skeletal cells, cardiomyocytes, daim siab hlwb, nrog rau tsim glucagon hlwb, somatostatin secreting cells, glial cells (oligodendrocytes), thiab donspamine. Yog li ntawd, umbilical qaum mesenchymal qia hlwb yog qhov tsim nyog rau kev siv tshuaj kho mob thiab kev tshawb fawb tshawb fawb.

Mesenchymal qia hlwb tau dhau los ua qhov kev tshawb fawb hotspot

Nyob rau hauv xyoo tas los no, kev tshawb fawb ntawm mesenchymal qia hlwb tau nce, thiab ClinicalTrials los ntawm NIH hauv Tebchaws Meskas yog lub ntiaj teb cov ntaub ntawv tshawb fawb loj tshaj plaws. Raws li kev tshawb fawb ntawm cov ntaub ntawv khaws cia, txij li lub Tsib Hlis 13, 2019, muaj 753 cov kev tshawb fawb soj ntsuam tau sau npe hauv cov ntaub ntawv hais txog mesenchymal qia hlwb. Ntawm lawv, tus naj npawb ntawm cov kev tshawb fawb soj ntsuam tau ua nyob rau hauv Tuam Tshoj, Europe, thiab Tebchaws Meskas nyob rau hauv peb lub ntiaj teb.

Los ntawm qhov kev xav ntawm hom kab mob kho, kev tshawb fawb soj ntsuam ntawm mesenchymal qia hlwb muaj ntau pua tus kab mob. Ntawm lawv, cov kab mob neurological, kab mob plawv, thiab orthopedic yog peb qhov kev tshawb fawb tseem ceeb, suav txog ntau dua 15%, thiab tag nrho tshaj li ib nrab. Tsis tas li ntawd, qhov kev faib ua feem ntawm ntshav qab zib, daim siab, ntsws, kab mob plab, daim tawv nqaij, kab mob autoimmune thiab graft tiv thaiv tus kab mob (GVHD) yog kwv yees li 5%, uas yog ib qho tseem ceeb soj ntsuam kev taw qhia ntawm mesenchymal qia hlwb.

Kev soj ntsuam daim ntawv thov kev tshawb fawb rooj plaub ntawm umbilical qaum mesenchymal qia hlwb

01.Metabolic kab mob

1.1 Ntshav Qab Zib

Tam sim no, tsis muaj kev kho mob hnyav rau cov ntshav qab zib hauv tsev kho mob, thiab peb tsuas yog tso siab rau cov tshuaj insulin lossis tshuaj hauv vitro kom txo cov ntshav qab zib, thiab tib lub sijhawm koom tes nrog kev noj haus thiab kev tawm dag zog. Mesenchymal qia hlwb muaj peev xwm txhawb nqa pancreatic islets β Kev ua haujlwm ntawm cell regeneration.

Hauv Suav teb, muaj peb lub tsev kho mob saum toj kawg nkaus uas tau ua cov kev tshawb fawb soj ntsuam ntawm mesenchymal qia cell transplantation hauv kev kho mob ntshav qab zib hom II. Cov neeg mob feem ntau tau ua tiav cov txiaj ntsig ntawm kev txo cov ntshav qab zib thiab insulin, thiab qee tus txawm tias tsis noj tshuaj. Nyob rau tib lub sijhawm, tus neeg mob lub cev tau zoo tuaj thiab lawv cov kev noj qab haus huv tau raug kho rau qee yam.

Fuzhou General Tsev Kho Mob ntawm Nanjing Tub Rog Cheeb Tsam tau tshawb fawb txog kev nyab xeeb thiab kev ua tau zoo ntawm txoj hlab ntaws mesenchymal qia hlwb ua ke nrog autologous pob txha pob txha mesenchymal qia hlwb hauv kev kho mob hom I ntshav qab zib yam tsis muaj kev tiv thaiv kab mob. Cov txiaj ntsig tau pom tias kev kho mob ntawm 42 tus neeg mob tau zoo. C-Pep nce los ntawm 105.7%, insulin 49.3%, HbA1c txo qis los ntawm 12.6%, ntshav qabzib ceev txo los ntawm 24.4%, thiab insulin xav tau txo los ntawm 29.2%.

1.2 Cov teeb meem ntawm ntshav qab zib

Mesenchymal qia hlwb muaj qhov kev thov dav dav hauv cov teeb meem ntawm ntshav qab zib.

1.2.1 Mob ntshav qab zib ko taw

Ntawm Shaanxi Provincial Tsev Kho Mob, nyob rau hauv cov xwm txheej tsis muaj menyuam, txoj hlab ntaws mesenchymal qia cell raug tshem tawm mus rau hauv cov leeg ntawm qhov ntev ntawm 3cm x 3cm ntawm qhov mob ntawm 5 tus neeg mob uas muaj ntshav qab zib hom II nyuaj nrog ntshav qab zib ko taw. Rau cov neeg uas muaj qhov mob hnyav, kev txhaj tshuaj yog qhov sib nrug ntawm 1cm x 1cm sib nrug ntawm ko taw, nrog rau kev tsom mus rau kev txhaj tshuaj ib ncig ntawm lub qhov txhab. Tom qab kev kho mob, qhov kev mob ntawm ko taw thiab loog loog tau txo qis, kev cuam tshuam ntawm claudication zoo dua, thiab cov kab mob zoo tag nrho.

Ntawm lub koom haum Anhui Provincial Tsev Kho Mob ntawm Anhui Medical University, umbilical qaum mesenchymal qia hlwb raug txhaj rau hauv qhov chaw mob ntawm cov ceg ceg cuam tshuam ntawm 53 tus neeg mob nrog qib II-IV mob ntshav qab zib ko taw. Tom qab peb lub hlis ntawm kev kho mob, piv rau pawg tswj hwm, pab pawg kho mob tau pom tias muaj kev txhim kho ntawm daim tawv nqaij kub, pob taws-brachial siab Performance index, tawv nqaij oxygen tension, thiab taug kev deb.

1.2.2 Mob ntshav qab zib nephropathy

Clinical Medical College ntawm Fuzhou General Tsev Kho Mob, Second Military Medical University, thiab Affiliated Changzheng Tsev Kho Mob ntawm Second Military Medical University tau kho 15 tus neeg mob nrog cov hlab ntsha mesenchymal qia hlwb los ntawm kev cuam tshuam hauv pancreatic dorsal artery, ob sab lub raum hlab ntsha, thiab peripheral leeg infusion. . Tom qab kev kho mob, cov neeg mob tau pom kev txhim kho hauv cov ntshav siab, ntshav qab zib, qib C-peptide, thiab cov cim qhia rau lub raum ua haujlwm. Raws li kev soj ntsuam kev ua tau zoo hauv kev txhim kho diastolic ntshav siab thiab lub raum ua haujlwm, pab pawg kho mob tau ua tiav cov pab pawg tswj hwm kho nrog qhov ncauj telmisartan ntxiv rau kev txhaj tshuaj subcutaneous insulin.

02.Neurological mob

2.1 Tus kab mob Parkinson

Thawj kis ntawm kev hloov cov qia cell rau tus kab mob Parkinson hauv Suav teb tau ua tiav hauv tsev kho mob hauv Shijiazhuang. Xie Xiyun, muaj hnub nyoog 76 xyoo los ntawm Indonesia, tau raug mob Parkinson tus kab mob tau ntau tshaj kaum xyoo, muaj kev nruj thiab kev sib cog lus ntawm peb tus ntiv tes ntawm nws sab tes xis, lub cev nruj, nqos nyuaj, thiab tsis muaj peev xwm saib xyuas tus kheej. Tsis pub dhau ob peb teev tom qab tau txais mesenchymal qia cell hloov, nws muaj peev xwm noj tau yooj yim thiab saib TV hmo ntawd, nrog kev txhim kho tseem ceeb hauv lwm cov tsos mob.

Dr. Sun Li los ntawm Tuam Tshoj Medical University infused ncua kev kawm ntawv uas muaj umbilical qaum mesenchymal qia hlwb rau hauv caj dab cov hlab ntsha ntawm 10 tus neeg mob Parkinson tus kab mob. Tom qab kev hloov pauv, cov neeg mob tau pom tias muaj kev txhim kho hauv kev taug kev, kev mob hnyav, kev yeem txav mus los, thiab muaj peev xwm zaum thiab sawv. Tsis tsuas yog nws tswj tau qhov kev loj hlob ntawm tus kab mob Parkinson, tab sis nws kuj tseem txhim kho kev ua haujlwm ntawm lub hlwb puas, yog li txhim kho lub neej zoo rau cov neeg mob.

2.2 senile dementia

Pab pawg coj los ntawm Zhou Qiang ntawm Jinyang Tsev Kho Mob hauv Guiyang City tau kho plaub tus neeg laus dementia siv cov pob txha pob txha autologous. Thawj tus neeg mob, ib tug txiv neej hnub nyoog 75 xyoo, tsis paub txog cov neeg hauv tsev neeg thaum tau txais kev tso cai thiab tsis muaj lub zais zis thiab tso quav. Tom qab kev hloov pauv, cov tsos mob no tau txhim kho sai, thiab thaum tso tawm, nws tsis tsuas yog lees paub nws cov neeg hauv tsev neeg xwb, tab sis kuj tau rov ua lub zais zis thiab lub plab zom mov.

2.3 Insomnia

Dr. Wang Yali los ntawm Zhejiang Armed Tub Ceev Xwm Tsev Kho Mob tau kho 19 tus neeg mob insomnia los ntawm kev txhaj tshuaj ntawm txoj hlab ntaws mesenchymal qia hlwb. Cov neeg mob no txhua tus tau ntsib teeb meem pw tsaug zog, tsis tsaug zog zoo, thiab tag nrho cov sij hawm pw tsaug zog tsawg dua 6 teev. Tom qab ib hlis ntawm kev kho mob, kev txhim kho ntawm kev pw tsaug zog zoo hauv cov neeg mob tau muab piv rau cov tshuaj ntawm qhov ncauj. Tom qab ob lub hlis ntawm kev kho mob, cov neeg mob pw tsaug zog zoo tau zoo dua li cov tshuaj noj qhov ncauj. Tom qab peb lub hlis ntawm kev kho mob, cov neeg mob pw tsaug zog zoo kuj tseem zoo dua li cov tshuaj noj ntawm qhov ncauj, thiab cov txiaj ntsig ntawm ib qho kev kho mob tuaj yeem kav ntev txog ib xyoos, txhim kho kev pw tsaug zog zoo hauv cov neeg mob.

03.Musculoskeletal mob

3.1 Degenerative leeg kab mob

Nyob rau xyoo 1990, Brittberg thiab lwm tus tau pib ua tiav qee yam hauv kev kho pob txha mos uas siv autologous chondrocytes. Yog li ntawd, ntau thiab ntau cov kev tshawb fawb pib tsom mus rau mesenchymal qia hlwb. Mesenchymal qia hlwb tuaj yeem sib txawv rau hauv ntau cov ntaub so ntswg thiab kho cov pob txha pob txha pob txha thiab cov pob txha subchondral.

Hauv kev tshawb fawb los ntawm Akgun et al. los ntawm Department of Orthopedics thiab Traumatology ntawm Istanbul University hauv Qaib Cov Txwv, lawv tau muab piv rau cov kev kho mob ntawm autologous pob txha pob txha mesenchymal qia hlwb thiab chondrocytes hauv 14 cov neeg mob osteoarthritis. Lawv pom tias cov neeg mob tau txais kev kho mob mesenchymal qia cell pom qhov kev txhim kho tseem ceeb hauv lub hauv caug raug mob thiab osteoarthritis cov qhab nia (KOOS) thiab cov qhab nia ntawm qhov pom kev sib piv (VAS).

Wakitani et al. los ntawm Feinberg Tsev Kawm Ntawv ntawm Tshuaj ntawm Northwestern University thiab Cleveland Clinic Tsev Kho Mob ntawm Ohio University tau ua qhov kev sim tshuaj siv mesenchymal qia hlwb. Hauv pab pawg sim, ib qho collagen gel tov nrog autologous pob txha pob txha-derived mesenchymal qia hlwb tau cog rau hauv cov neeg mob cov pob txha pob txha pob txha, thaum pawg tswj tau txais qhov sib npaug ntawm collagen gel. Ob pab pawg tau pom tias muaj kev txhim kho hauv kev sib koom ua haujlwm, tab sis tsuas yog pab pawg sim tau pom cov pob txha pob txha pob tshab ntawm qhov chaw raug mob. Lawv tau ua raws li 41 tus neeg mob uas tau txais kev kho mob mesenchymal qia cell mus txog 11 xyoo thiab tsis pom muaj teeb meem loj.

04.Reproductive system kab mob

4.1 Kev xeeb tub

Kho kev puas tsuaj loj rau lub endometrium, uas yog npau suav phem ntawm ntau tus poj niam tsis muaj menyuam, tam sim no ua tau los ntawm mesenchymal qia cell regenerative technology, coj kev cia siab los ua kom tiav cov poj niam txoj kev npau suav ntawm niam.

Xib fwb Hu Yali pab neeg los ntawm Obstetrics thiab Gynecology Department ntawm Gulou Tsev Kho Mob nyob rau hauv Nanjing, koom tes nrog xib fwb Dai Jianwu pab neeg los ntawm lub koom haum ntawm noob caj noob ces thiab kev loj hlob Biology ntawm Suav Academy ntawm Sciences, ua tau zoo tsim, thawj zaug nyob rau hauv lub ntiaj teb no, ib txoj kev los ua ke. collagen scaffolds nrog mesenchymal qia hlwb. Los ntawm kev sib koom ua ke cov txheej txheem hysteroscopic, lawv ua tiav kev kho ntawm cov endometrium puas, pab peb cov neeg mob ua tiav lawv txoj kev npau suav ntawm kev ua niam.

Ms. Hu los ntawm Yancheng, Jiangsu, tau ntsib peb txoj kev nchuav menyuam thaum muaj hnub nyoog 31 txog 34 xyoos, ua rau muaj kev sib txuam hnyav hauv nws lub tsev menyuam vim yog kev phais uterine tom qab yug menyuam. Siv cov kab mob mesenchymal, Tsev Kho Mob Gulou hauv Nanjing tau ua tiav kho nws cov endometrium nyob rau hauv yim lub hlis. Qhov no ua rau nws xeeb tub tau zoo, thiab thaum Lub Xya Hli 17, 2014, nws yug tau thawj tus menyuam "cov tshuaj kho dua tshiab" hauv Suav teb.

Nanjing Gulou Tsev Kho Mob lub mesenchymal qia cell "endometrial regeneration phais" tau ua tiav 13 tus neeg mob tsis muaj menyuam uas muaj cov kab mob uterine hnyav adhesions kom xeeb tub thiab yug me nyuam, ua rau tag nrho 14 noj qab haus huv "cov menyuam mos noj qab haus huv."

4.2 Lub zes qe menyuam ua tsis tiav

Lub zes qe menyuam ua tsis tiav yog hais txog qhov tshwm sim uas cov poj niam muaj lub zes qe menyuam atrophy thiab nres ovulating ua ntej hnub nyoog 40. Tam sim no, kwv yees li 1% ntawm cov poj niam uas muaj hnub nyoog yug me nyuam thoob ntiaj teb muaj kev ua tsis tiav ntxov ntxov ntawm zes qe menyuam, ua rau cov poj niam tsis muaj menyuam.

Xib Fwb Wu Ji thiab nws pab neeg los ntawm Shanghai Jiao Tong University hauv Suav teb cais cov poj niam cov qe qe menyuam los ntawm ib- mus rau ob lub lis piam-laus ntsuab fluorescent protein transgenic nas. Tom qab kev ua kom huv, kab lis kev cai, thiab lwm yam txheej txheem, cov hlwb no tau hloov mus rau hauv nas nrog lub zes qe menyuam ntxov ntxov. Cov txiaj ntsig kev tshawb fawb tau pom tias poj niam cev xeeb tub qia hlwb, zoo li lwm cov qia hlwb, muaj cov khoom siv hauv tsev. Tom qab yug me nyuam, qee lub hlwb sib txawv thiab maj mam tsim mus rau hauv cov laus oocytes, yog li rov ua haujlwm ntawm zes qe menyuam.

4.3 Erectile kawg (ED)

Siv cov qia cell kho rau erectile kawg tuaj yeem hloov pauv cov ntaub so ntswg puas los yog tuag penile thiab secrete yam los kho lub cev tsis muaj zog ntawm tes.

Kaum tsib tus neeg mob erectile kawg hauv Denmark tau txais mesenchymal qia cell infusions yam tsis muaj tshuaj lossis hloov chaw penile. Tom qab rau lub hlis, yim tus txiv neej tuaj yeem koom nrog kev sib deev ib txwm.

05.Cov kab mob autoimmune

Xyoo 2007, Xib Fwb Sun Lingyun hauv Suav teb tau ua tiav ob qhov kev kho mob ntawm cov kab mob lupus erythematosus siv mesenchymal qia hlwb, thiab xyoo tom ntej, nws tau kho cuaj kis ntxiv. Tom qab kev kho mob, cov tsos mob ntawm cov neeg mob tau txo qis, thiab tsis muaj kev rov tshwm sim dua thaum 6 lub hlis tom qab.

Hauv xyoo 2012, Lub Tsev Haujlwm Rheumatology thiab Immunology ntawm Jiangsu University Affiliated Tsev Kho Mob tau tso cov kab mob hauv cov hlab ntsha mesenchymal qia hlwb rau 21 cov neeg mob uas muaj cov kab mob lupus erythematosus, uas txo qis cov zis protein ntau hauv cov neeg mob, txo cov kab mob ua haujlwm, thiab txo qis E Systemthematosus. Tus qhab nia ntawm Kab Mob Kev Ua Si.

Qhov cuam tshuam ntawm mesenchymal qia cell transplantation ntawm cov kab mob kev ua haujlwm thiab cov zis tso zis hauv cov neeg mob uas muaj kab mob lupus erythematosus (SLE)

Xyoo 2013, Lub Tsev Kho Mob Rheumatology thiab Immunology ntawm Thawj Tsev Kho Mob ntawm Yangtze University thiab Jingzhou First People's Tsev Kho Mob tau tswj hwm txoj hlab ntaws mesenchymal qia hlwb ntawm cov kab mob anterior cubital rau 18 cov neeg mob uas muaj kab mob lupus erythematosus. Ib hlis tom qab, cov neeg mob feem ntau pom tau tias muaj kev txhim kho tseem ceeb hauv cov tsos mob thiab cov tsos mob xws li kub taub hau, qaug zog, thiab tsis muaj zog piv rau ua ntej hloov pauv.

06. Anti-aging

Kev laus ntawm tib neeg lub cev muaj feem xyuam rau qhov tsis txaus lossis tsis muaj zog qia cell kom muaj nuj nqis. Thaum muaj hnub nyoog nce, muaj kev poob qis hauv ob qho tib si kom muaj nuj nqis thiab zoo ntawm cov qia hlwb hauv lub cev. Cov qauv no ua rau kev poob qis thiab kev laus ntawm cov hlwb puas thiab cov kabmob thiab cov ntaub so ntswg uas muaj cov hlwb, ua rau muaj kev noj qab haus huv zoo thiab kev laus. Mesenchymal qia hlwb muaj peev xwm ua tau ntau yam sib txawv, muaj peev xwm sib txawv rau ntau hom qia hlwb uas xav tau hauv lub cev. Los ntawm kev ntxiv cov qia hlwb tsis txaus hauv lub cev thiab kho cov kab mob thiab cov ntaub so ntswg puas, mesenchymal qia hlwb ua lub luag haujlwm hauv kev tiv thaiv kev laus.

Nrog rau kev txaus siab ntxiv thiab kev siv ntawm txoj hlab ntaws mesenchymal qia cell tshawb fawb, nws ntseeg tau tias nyob rau yav tom ntej, lawv yuav siv dav hauv cov chaw kho mob, yog li muab txiaj ntsig ntau dua rau tib neeg kev noj qab haus huv.