Mishonga
Advanced Neurotrophic factor therapy
Chii chinonzi immune cells?
Masero ekudzivirira muviri anoreva boka riri mumuviri wemunhu rinonyanya "kudzivirira." Inowanzozivikanwa semasero machena eropa, masero ekudzivirira anosanganisira lymphocytes akasiyana-siyana uye phagocytes anogona kuziva uye kubvisa maantigen, achibatanidzwa mumhinduro dzekudzivirira zvirwere. Muviri wedu wakafanana nenyika yakazvimirira, uye immune system inoshanda semauto edu nemapurisa. Izvo hazvingoite semauto kuona nekubvisa utachiona hunopinda asi zvakare hunoshanda semapurisa kuziva nekubvisa maseru akachinja, ari kufa, kana zvimwe zvinhu zvinokuvadza mukati memuviri.
Mabasa emasero emuviri
Enhancing Immunity:Kushandisa immune system kuvandudza kugona kurwisa hutachiona uye hutachiona.
Kuvandudza Suboptimal Health:Kudzora immune system kurwisa hutachiona uye mavhairasi, kuvandudza cellular metabolic masimba, uye nekuwedzera hutano hwese.
Anti-kuchembera:Kukurudzira metabolism, nekukurumidza kubvisa masero akafa uye achembera kunonoka kuchembera.
Kudzivirira kenza uye Kurapa:Kusimbisa kugona kwemuviri kurwisa mapundu, kuchenesa masero akachinja panguva yakakodzera, nekudaro kudzivirira nekurwisa masero emamota.
NK Sero
Applicable Population:Kuvandudza hutano husina kunaka / kuchembera kwepakutanga; post-tumor kuvhiyiwa kudzivirira.
Matanho Akakosha:Inoda in vitro kuwedzera kwenhamba huru yemasero.
Zvakanakira:Kukurumidza kutanga kwekuuraya nzira, yakakura spectrum yemhando dzemamota.
DC Cell
Applicable Population:Kudzivirira post-tumor kuvhiyiwa.
Matanho Akakosha:Kuunganidzwa kubva ku autologous peripheral blood.
Zvakanakira:Yakasimba antigen mharidzo, kunyatsobatwa kwebundu zviratidzo.
CAR-T Sero
Applicable Population:Hematologic tumors, mamwe mamota akasimba.
Matanho Akakosha:Kuunganidzwa kubva ku autologous peripheral blood.
Zvakanakira:Kunyatsozivikanwa kwema tumor masero, ane ndangariro.
TO Sero
Inoshanda Population: Post-bundu kuvhiyiwa kudzivirira.
Matanho Akakosha: Kuwana kubva ku autologous tumor tissue.
Zvakanakira: Kugona kuuraya kwakasimba, kupinda nyore kwe tumor microenvironment.
Mamiriro Ekushandisa eMasero Anodzivirira Mudziviriro
Kubudirira kweNeurotrophic factor therapy kunopa kukosha kunooneka pamasero edziviriro.
Nyaya Yekutanga:
Kuongororwa kwemakiriniki kunoratidza kuti varwere vekenza yemapapu vakanonoka, mushure meNK cell therapy, vakawana kudzora kwechirwere. Mhedzisiro yemhedzisiro inoratidza kuti NK cell immunotherapy inogona kushandiswa seye adjuvant kurapa mukurapwa kwevanononoka-danho remapapu varwere.
Yekuedza Background: Chinangwa chaive chekuongorora kushanda kweyakanyanya activated NK (HANK) cell immunotherapy mune yekupedzisira-danho remapapu varwere. Varwere gumi nevatatu (8 varume, 5 vakadzi) vane makore epakati pemakore 57.3, vakaonekwa kuti vane adenocarcinoma (n = 12) kana squamous cell carcinoma (n = 1), vakabatanidzwa. Matanho IV, III, uye II akaonekwa mu10, 2, uye 1 murwere (s), zvichiteerana. Masero emononuclear akaparadzaniswa nevarwere, uye NK masero akawedzerwa.
Kushandiswa: Murwere wega wega akagamuchira kanenge kosi imwe chete (yega yega yaisanganisira infusions matatu, uye imwe neimwe infusion inogara mukati me30 maminetsi). Kurapa kwemwedzi hakuna kudarika makosi matatu. Kosi yega yega yaisanganisira matatu akateedzana infusions, inogara kwemazuva matatu (inenge 3-5 × 10 ^ 9 HANK masero akaunganidzwa muhomwe yekuisira zuva rega rega, aine infusion concentration ye2 × 10 ^ 7 / mL). Lymphocyte subsets, cytokine production, uye kutaura kwecarcinoembryonic antigen (CEA) uye thymidine kinase 1 (TK1) yakayerwa isati yarapwa uye mushure mekuiswa kwekupedzisira.
Results: Hapana mhedzisiro yakaonekwa. Mushure memwedzi we3 kutevera, chiyero chevarwere vane chirwere chakagadzikana uye chinopfuurira chaiva 84.6% uye 15.4%, maererano. Uyezve, IFN-γ mazinga akawedzera zvakanyanya mushure mekurapwa, uye mazinga eECA akaderera zvakanyanya. Iyo yese immune system yevarwere vanogamuchira NK cell therapy yakaramba yakagadzikana.
Muna Mbudzi 1984, Linda Taylor, mukadzi weUS Navy servicewoman ane advanced metastatic melanoma, akapinda mukiriniki kuyedza tumor immunotherapy yakatungamirwa naDr. Steven Rosenberg veNational Cancer Institute (NCI). Akapona uye akave murwere wekutanga pasi rose kuporeswa neNeurotrophic factor therapy.
Muna 2012, Emily Whitehead ane makore matanhatu akave mwana wekutanga pasi rose kuita ongororo yekurapa sero. Akapinda muchidzidzo cheYunivhesiti yePennsylvania paCAR-T kurapwa kwehudiki acute lymphoblastic leukemia uye akawanazve hupenyu hutsva, achirarama neutano kusvika nhasi.
Musi waApril 5, 2016, chirongwa cheCCTV-10 "Resurrected NK Cells" yakashuma kuti Ms. Tang, 58 wemakore panguva iyoyo, akawana simba rakavandudzwa uye kusimbiswa kwekudzivirira kuburikidza neNK cell transfusion, kubvisa hutano hwake husina kunaka.
Mushure memakumi emakore ekuedza kusingaperi uye kutsvagisa kunoitwa nezvizvarwa zvakawanda zvesainzi, kunzwisisa kwedu basa remasero edziviriro uye kuongorora kukosha kwekiriniki kwemasero edziviriro ari kuramba achigonesa maseru edziviriro kuti atambe mamwe mabasa.
Isu tinotenda kuti sekutsvagisa uye kushandiswa kwemaseru ekudzivirira kunoramba kuchidzika, maseru edziviriro, sevanochengeta hutano hwevanhu, anozobatsira mukusimudzira kwemhando yepamusoro yekuedza kwehutano hwevanhu.