Unyango
Advanced Neurotrophic factor therapy
Ziziphi iiseli zomzimba?
Iiseli ze-immune zibhekisela kwiqela kumzimba womntu okhethekileyo "ekukhuseleni." Ngokuqhelekileyo kwaziwa ngokuba ziiseli ezimhlophe zegazi, iiseli zokuzivikela zibandakanya i-lymphocytes ezahlukeneyo kunye ne-phagocytes ezinokuqaphela kunye nokuphelisa i-antigens, ukuthatha inxaxheba kwiimpendulo ze-immune. Umzimba wethu ufana nelizwe elizimeleyo, kwaye amajoni omzimba asebenza njengomkhosi wethu wamajoni namapolisa. Ayisebenzi nje njengomkhosi ukuchonga kunye nokuphelisa iipathogens ezihlaselayo kodwa ikwasebenza njengamapolisa ukuqonda kunye nokuphelisa iiseli eziguqukileyo, ezifayo, okanye ezinye izinto eziyingozi emzimbeni.
Imisebenzi yeeseli zomzimba
Ukwandiswa koKhuseleko:Ukuvuselela amajoni omzimba ukuphucula amandla okulwa nohlaselo lwentsholongwane kunye neebhaktheriya.
Ukuphucula iMpilo eNgcono:Ukulawula amajoni omzimba ukumelana nosulelo kunye neentsholongwane, ukuphucula amandla e-metabolic eselula, kunye nokuphucula ngokupheleleyo impilo yonke.
Ukuchasa ukuguga:Ukukhuthaza imetabolism, ngokukhawuleza ukuphelisa iiseli ezifileyo kunye ezigugayo ukulibazisa ukuguga.
UThintelo loMhlaza kunye noNyango:Ukomeleza amandla omzimba okuxhathisa amathumba, ukucocwa kwangexesha iiseli eziguquliweyo, ngaloo ndlela kuthintela nokuhlasela iiseli zethumba.
Iseli ye-NK
Abemi abaSebenzisayo:Ukuphucula impilo engafanelekanga/ukuguga kwangoko; ukuthintela utyando emva kwethumba.
Amanyathelo aphambili:Ifuna ukwandiswa kwe-in vitro yenani elikhulu leeseli.
Izinto eziluncedo:Ukuqaliswa ngokukhawuleza kweendlela zokubulala, uluhlu olubanzi lweentlobo zethumba.
DC Cell
Abemi abaSebenzisayo:Ukuthintela utyando lwasemva kwethumba.
Amanyathelo aphambili:Ukuqokelelwa kwigazi le-autologous peripheral.
Izinto eziluncedo:Ukubonakaliswa kwe-antigen eyomeleleyo, ukubanjwa ngokuchanekileyo kweempawu ze-tumor.
Iseli ye-CAR-T
Abemi abaSebenzisayo:Amathumba e-Hematologic, amathumba athile aqinileyo.
Amanyathelo aphambili:Ukuqokelelwa kwigazi le-autologous peripheral.
Izinto eziluncedo:Ukuchongwa ngokuchanekileyo kweeseli zethumba, ezinenkumbulo.
UKUYA kwiSeli
Abemi abaSebenzayo: Ukuthintela utyando lwasemva kwethumba.
Amanyathelo aPhambili: Ukufumana kwi-autologous tumor tissue.
Izinto eziluncedo: Ubuchule bokubulala obunamandla, ukungena lula kwe-tumor microenvironment.
Iimeko zokuSebenza kweeSeli zoKhuseleko lwamajoni omzimba
Impumelelo yonyango lwe-Neurotrophic factor inika ixabiso elibonakalayo ngakumbi kwiiseli zomzimba.
Ityala lokuqala:
Uqwalaselo lweklinikhi lubonisa ukuba izigulane ezinomhlaza wemiphunga emva kwexesha le-NK, emva konyango lweseli ye-NK, zizuze ulawulo oluzinzileyo lwesifo. Iziphumo zovavanyo zingqina ukuba i-NK cell immunotherapy ingasetyenziswa njengonyango lwe-adjuvant kunyango lwezigulane zomhlaza wemiphunga.
Imvelaphi yoMfuniselo: Injongo yayikukuphonononga ukusebenza ngempumelelo kwe-NK (HANK) yonyango lokhuselo lomzimba kwiseli kwisigaba samva nje somhlaza wemiphunga. Izigulane ezilishumi elinesithathu (amadoda ayi-8, amabhinqa angama-5) aneminyaka engama-57.3 ubudala, afunyanwe ukuba ane-adenocarcinoma (n = 12) okanye i-squamous cell carcinoma (n = 1), ifakiwe. Izigaba IV, III, kunye ne-II zifunyenwe kwi-10, i-2, kunye ne-1 isigulane (s), ngokulandelanayo. Iiseli ze-Mononuclear zahlukaniswa kwizigulane, kwaye iiseli ze-NK zandiswa.
Ukusetyenziswa: Isigulane ngasinye sifumene ubuncinane ikhosi enye (ikhosi nganye yayiquka ukunyuswa okuthathu, kunye nokufakwa kwe-infusion nganye kwimizuzu engama-30). Unyango lwenyanga aludlulanga kwiikhosi ezintathu. Ikhosi nganye ibandakanya ukutyunjwa okuthathu okulandelelanayo, okuhlala iintsuku ezintathu (malunga ne-3-5 × 10 ^ 9 iiseli ze-HANK zaqokelelwa kwisikhwama sokumpontshelwa imihla ngemihla, kunye ne-infusion concentration malunga ne-2 × 10 ^ 7 / mL). I-Lymphocyte subsets, ukuveliswa kwe-cytokine, kunye nokubonakaliswa kwe-carcinoembryonic antigen (CEA) kunye ne-thymidine kinase 1 (TK1) zilinganiswe ngaphambi kokuba unyango kwaye emva kokunyuswa kokugqibela.
Iziphumo: Akukho miphumo emibi yabonwa. Emva kokulandelelana kweenyanga ze-3, umlinganiselo wezigulane ezinezifo ezizinzile kunye nenkqubela phambili ziyi-84.6% kunye ne-15.4%, ngokulandelanayo. Ukongezelela, amanqanaba e-IFN-γ anda kakhulu emva kokunyanga, kwaye amanqanaba e-CEA ancipha kakhulu. Umsebenzi we-immune jikelele wezigulane ezifumana unyango lwe-NK cell wahlala uzinzile.
NgoNovemba 1984, uLinda Taylor, ibhinqa lase-US Navy servicewoman kunye ne-melanoma ye-metastatic ephezulu, uthathe inxaxheba kulingo lwezonyango lwe-tumor immunotherapy ekhokelwa nguGqr Steven Rosenberg we-National Cancer Institute (NCI). Wasinda ngempumelelo kwaye waba sisigulana sokuqala ehlabathini enyangwa lunyango lweNeurotrophic factor.
Ngo-2012, u-Emily Whitehead oneminyaka emi-6 ubudala waba ngumntwana wokuqala kwihlabathi ukuba afumane unyango oluvavanyiweyo lweeseli. Uthathe inxaxheba kuphononongo lweDyunivesithi yasePennsylvania kunyango lwe-CAR-T kunyango lwe-acute lymphoblastic leukemia ebuntwaneni kwaye waphinda wafumana ubomi obutsha, ephila ngokusempilweni ukuza kuthi ga namhlanje.
Ngomhla we-5 ku-Epreli 2016, inkqubo ye-CCTV-10 "Iiseli ze-NK ezivuselelweyo" zabika ukuba uNksz Tang, oneminyaka engama-58 ubudala ngelo xesha, wafumana amandla aphuculweyo kunye nokukhuselwa kwamajoni omzimba ngokumpontshelwa kweseli ye-NK, ukuphelisa isimo sakhe sempilo esincinci.
Emva kwamashumi eminyaka yemizamo engayekiyo kunye nophando olusebenzayo lwezizukulwana ezininzi zezazinzulu, ukuqonda kwethu indima yeeseli zomzimba kunye nokuphonononga ukubaluleka kweklinikhi yeeseli zokhuselo lomzimba ngokuqhubekayo zenza iiseli zokhuselo lomzimba zidlale indima eninzi.
Sikholelwa ukuba njengoko uphando kunye nokusetyenziswa kweeseli zomzimba ziqhubeka zinzulu, iiseli zomzimba, njengabagcini bempilo yabantu, ziya kuba negalelo ekuphuhliseni umgangatho ophezulu wemizamo yempilo yabantu.