Kev Cia Siab Tshiab rau Cov Neeg Mob Cancer: Pab Pawg Harvard tsim DC Super-Activator Vaccine

Taw qhia

Raws li peb muaj hnub nyoog, lub cev tiv thaiv kab mob maj mam poob qis, ua rau nws muaj kev cuam tshuam ntau dua los ntawm cov kab mob thiab cov kab mob, thaum qhov tshwm sim ntawm mob qog noj ntshav nce ntxiv. Kev tshawb fawb tau pom tias ntau dua ob feem peb ntawm cov mob qog noj ntshav tshiab tau tshwm sim hauv cov tib neeg hnub nyoog 60 thiab siab dua. Qhov no qhia txog kev sib raug zoo ntawm kev tiv thaiv kab mob thiab kev laus. Yog tias peb tuaj yeem txhim kho kev tiv thaiv kab mob hauv cov neeg laus, nws yuav muaj txiaj ntsig zoo rau lawv txoj kev noj qab haus huv tag nrho.

Thaum Lub Rau Hli 12, 2024, Xib Fwb Jonathan C. Kagan pab pawg los ntawm Tsev Kawm Ntawv Kho Mob Harvard tau luam tawm ib daim ntawv hu ua "Kev kho cov hnub nyoog cuam tshuam nrog cov kab mob dendritic ua rau CD4+ T hlwb kom tshem tawm cov qog" hauv phau ntawv journal *Cell*. Tsab ntawv tshaj tawm qhia tias los ntawm kev cuam tshuam hauv kev ua ntawm cov hlwb dendritic, nws muaj peev xwm kho cov hnub nyoog ntsig txog lub cev tsis muaj zog, yog li txhim kho lub peev xwm ntawm CD4 + T hlwb kom tshem tawm cov qog. Qhov no muab txoj hauv kev tshiab rau kev kho mob qog noj ntshav hauv cov neeg laus.

Tshawb nrhiav qhov cuam tshuam ntawm Hnub Nyoog ntawm Kev Ua Haujlwm ntawm Cancer Immunotherapy

Pab neeg tshawb fawb thawj zaug siv tus qauv melanoma nas thiab kho cov nas nrog PD-1 thiab CTLA4 qog immunotherapy los ntsuas lub zog ntawm lub cev tiv thaiv kab mob kev tiv thaiv kab mob hauv cov nas ntawm cov hnub nyoog sib txawv. Lawv pom tias thaum cov qog hauv cov nas me tuaj yeem kho tau, cov qog hauv cov nas laus tsis tuaj yeem tshem tawm. Qhov txiaj ntsig no tau txuas nrog ob lub hnub nyoog paub txog kev tiv thaiv kab mob tsis muaj zog: kev txo qis hauv cov naj npawb ntawm cov T hlwb tsis muaj zog thiab tsis muaj zog dendritic cell (DC) kev ua haujlwm.

Dendritic cells (DCs) muaj npe rau cov kev kwv yees dendritic uas lawv txuas ntxiv thaum loj hlob. Lawv ua lub luag haujlwm tseem ceeb hauv ob qho tib si hauv lub cev thiab lub cev tiv thaiv kab mob thiab yog cov muaj zog tshaj plaws antigen-tam sim no hlwb. DCs muaj peev xwm txhawb nqa T hlwb tsis zoo los pib lub cev tiv thaiv kab mob hauv lub cev.

Pab pawg tau tsim cov tshuaj tiv thaiv DC cell super-activator, uas tuaj yeem kho cov kab mob tiv thaiv kab mob hauv cov nas laus.

Txoj kev tshawb nrhiav pom tias kev ua haujlwm tsis txaus ntawm DC hlwb tuaj yeem ua rau tsis muaj kev tiv thaiv tus tswv tsev pom hauv cov neeg laus. Yog li ntawd, cov kws tshawb fawb tau tsim DC super-activator ua cov tshuaj tiv thaiv kab mob. Qhov no adjuvant tuaj yeem kho qhov kev hloov pauv ntawm DC hlwb hauv cov nas laus, ua rau muaj kev ua haujlwm cytolytic hauv T pab 1 (TH1) CD4+ T hlwb, thiab txhim kho cov qog tiv thaiv kab mob hauv cov nas laus.

Kev tswj hwm DC Cell Kev Ua Haujlwm thim rov qab hnub nyoog ntsig txog lub cev tsis muaj zog

Cov txiaj ntsig ntawm kev tshawb fawb qhia tau hais tias peb tuaj yeem kho qhov muaj hnub nyoog txog kev tiv thaiv kab mob los ntawm kev ua haujlwm dendritic cell, qhia tias kev tiv thaiv kab mob tsis zoo hauv cov neeg laus yog rov qab los. Qhov no muaj qhov cuam tshuam tseem ceeb rau kev txhim kho lub neej zoo rau cov neeg laus thiab sawv cev rau kev txhim kho mob qog noj ntshav rau cov hnub nyoog no.

Dendritic hlwb, raws li cov xaim ntawm lub cev tiv thaiv kab mob, ua lub luag haujlwm tseem ceeb hauv kev kho mob qog noj ntshav. Lawv tuaj yeem ua haujlwm tau zoo thiab coj T hlwb kom paub txog thiab rhuav tshem cov qog nqaij hlav cancer, yog li pib muaj kev tiv thaiv qog noj ntshav hauv tus neeg mob lub cev.

Cov ntaub ntawv

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Kev kho lub hnub nyoog cuam tshuam nrog cov tsis xws luag hauv cov hlwb dendritic ua rau CD4 + T hlwb tshem tawm cov qog. Cell. 2024 Lub Xya Hli 25; 187(15): 3888-3903.e18. doi: 10.1016/j.cell.2024.05.026.

Kev kho cov hnub nyoog cuam tshuam nrog cov tsis xws luag hauv cov hlwb dendritic ua rau CD4 + T hlwb kom tshem tawm cov qog

Cell

Ib: 41.584

2024.6.12

Noulai Medical Oncology Rehabilitation Center

Noulai Medical Oncology Rehabilitation Center siv 1 + 4 kev kho mob qog noj ntshav los ntawm kev siv tshuaj tiv thaiv kab mob, ua ke nrog kev noj zaub mov, txhawb kev puas siab puas ntsws, tswj kev pw tsaug zog, thiab tshuaj suav tshuaj. Txoj hauv kev no pab cov neeg mob qog noj ntshav rov qab kho lawv lub cev tiv thaiv kab mob, txhim kho lawv txoj sia nyob tsib xyoos, thiab txhim kho lawv lub neej zoo.

Core Technologies ntawm Oncology Rehabilitation Center

Lub Nolai Kho Mob Oncology Rehabilitation Center siv cov cuab yeej tshwj xeeb lub hom phiaj dendritic cell (T-DC) thev naus laus zis los txheeb xyuas cov qog nqaij hlav, lub hom phiaj thiab tshem tawm cov qog nqaij hlav cancer hauv tus neeg mob lub cev. Txoj hauv kev no, ua ke nrog CIK cell therapy, txhim kho kev tiv thaiv kab mob thiab kho tus neeg mob lub cev tiv thaiv kab mob.