Comprehensive Lupus Management

Qhov laj thawj ntawm SLE tsis meej, tab sis kev sib cuam tshuam ntawm caj ces thiab ib puag ncig yog ntseeg tau ua lub luag haujlwm tseem ceeb. Kev ua kom tsis zoo ntawm lub cev tiv thaiv kab mob ua rau muaj kev tawm tsam autoimmune, ua rau muaj kev puas tsuaj rau lub cev thiab cov khoom nruab nrog cev.

Genetic Factors:SLE nyiam khiav hauv tsev neeg, thiab cov neeg txheeb ze ntawm cov neeg mob muaj qhov tshwm sim ntau dua piv rau cov pej xeem. Qhov tshwm sim hauv cov menyuam ntxaib zoo ib yam yog ntau dua li ntawm cov menyuam ntxaib hauv fraternal, qhia txog kev sib raug zoo ntawm SLE thiab caj ces yam.

Environmental Factors:
Tshav ntuj: SLE cov neeg mob feem ntau ntsib cov kab mob flares tom qab lub hnub raug, tej zaum yog vim ultraviolet-induced cell apoptosis ua rau muaj antigen.

Tshuaj thiab Tshuaj: Cov tshuaj tiv thaiv sab nraud tuaj yeem qhib lub cev tiv thaiv kab mob, ua rau autoantibody ntau lawm thiab cov ntaub so ntswg puas. Cov tshuaj xws li procainamide, hydralazine, quinidine, thiab lwm yam tuaj yeem ua rau SLE.
Cov kab mob: Cov kab mob pathogenic (xws li cytomegalovirus, kab mob siab C, Epstein-Barr virus, thiab lwm yam) ua zoo ib yam li cov tshuaj, feem ntau ua rau kev tsim cov autoantibodies los ntawm lub cev tiv thaiv kab mob.

Estrogen: Feem ntau hom SLE muaj ntau dua rau cov poj niam uas muaj hnub nyoog me nyuam. Kev xeeb tub thiab kev siv tshuaj estrogen (xws li cov tshuaj tiv thaiv kab mob) tuaj yeem ua rau tus kab mob hnyav dua. Cov kev sim tsiaj tau pom tias cov tshuaj estrogen exacerbates lupus hauv cov tsiaj txhu, thaum testosterone txo cov tsos mob, qhia txog kev sib raug zoo ntawm cov tshuaj estrogen thiab qhov pib ntawm SLE.

Cov tsos mob ntawm SLE muaj ntau haiv neeg thiab suav nrog, tab sis tsis txwv rau:

Cov tsos mob ntawm daim tawv nqaij: pob khaus, npauj npaim zoo li lub ntsej muag ua pob liab liab (malar pob), photosensitivity, thiab lwm yam.

Cov tsos mob ntawm pob qij txha: mob caj dab, mob pob qij txha, pob qij txha o.

Cov tsos mob ntawm lub raum: Proteinuria, hematuria, uas yuav ua rau nephritis.

Cov tsos mob ntawm lub plawv: Pericarditis, valvular lub plawv puas.

Central Nervous System Cov tsos mob: mob taub hau, qaug dab peg, kev paub tsis meej.

Kev kuaj mob ntawm SLE muaj ob peb kauj ruam:

Kev sab laj: Tus kws kho mob nug txog cov tsos mob loj, cov tsos mob ntsig txog, lub sijhawm, kev kuaj mob yav dhau los, kev kho mob, tsev neeg keeb kwm, thiab lwm yam.

Kev kuaj lub cev: Ib qho kev ntsuam xyuas thiab kev ntsuas ntawm lub cev, suav nrog daim tawv nqaij, plaub hau, qhov ncauj kab noj hniav, thiab pob qij txha, thiab lwm yam.

Cov Kev Ntsuas Tseem Ceeb: Kev kuaj ntshav, kuaj zis, kev tshawb fawb pom, raum biopsies, thiab lwm yam. Lub raum biopsies koom nrog kev phais me me uas tau txais ib daim me me ntawm lub raum cov ntaub so ntswg hauv zos rau kev kuaj kab mob thiab immunopathological.

Sib nrug los ntawm cov kab mob ntawm daim tawv nqaij, kev kuaj histopathological thiab kuaj ntshav ua pov thawj kuaj mob. Kev kuaj immunopathological yog qhov muaj txiaj ntsig zoo hauv kev kuaj mob. Cov tshuaj tiv thaiv kab mob zoo autoantibodies, xws li cov tshuaj tiv thaiv nuclear (ANA), cov tshuaj tiv thaiv dsDNA, cov tshuaj tiv thaiv Sm, thiab lwm yam, yog cov yam ntxwv. Kev hloov pauv hauv cov tshuaj tiv thaiv kab mob tuaj yeem cuam tshuam txog kev ua haujlwm ntawm cov kab mob, thiab cov neeg mob SLE nquag nquag pom tias muaj qhov nce ntxiv ntawm erythrocyte sedimentation. Urinalysis tuaj yeem pom cov proteinuria, cov qe ntshav liab / dawb, thiab cov cellular casts.