Chithandizo
Advanced Neurotrophic factor therapy
Kodi maselo a chitetezo cha mthupi ndi chiyani?
Maselo a chitetezo cha mthupi amatanthawuza gulu la thupi la munthu lodziwika bwino mu "chitetezo." Odziwika bwino monga maselo oyera a magazi, maselo oteteza thupi amaphatikizapo ma lymphocyte osiyanasiyana ndi phagocytes omwe amatha kuzindikira ndi kuchotsa ma antigen, kutenga nawo mbali mu mayankho a chitetezo cha mthupi. Thupi lathu ndi lofanana ndi dziko lodziimira palokha, ndipo chitetezo cha mthupi chimagwira ntchito ngati gulu lathu lankhondo ndi apolisi. Sizimagwira ntchito ngati gulu lankhondo kuti lizindikire ndikuchotsa tizilombo toyambitsa matenda komanso limagwira ntchito ngati apolisi kuzindikira ndikuchotsa maselo osinthika, akufa, kapena zinthu zina zovulaza m'thupi.
Ntchito za chitetezo cha mthupi
Kupititsa patsogolo chitetezo chokwanira:Kulimbikitsa chitetezo chamthupi kuti chithandizire kulimbana ndi ma virus ndi mabakiteriya.
Kupititsa patsogolo Thanzi Labwino Kwambiri:Kuwongolera chitetezo chamthupi kukana matenda ndi ma virus, kupititsa patsogolo mphamvu zama metabolic m'ma cell, komanso kupititsa patsogolo thanzi lonse.
Anti-Kukalamba:Kulimbikitsa kagayidwe, kuchotsa mwamsanga maselo akufa ndi okalamba kuti achedwetse kukalamba.
Kupewa ndi Kuchiza Khansa:Kulimbitsa mphamvu ya thupi yolimbana ndi zotupa, kuchotsa maselo osinthika panthawi yake, motero kuteteza ndi kuukira maselo otupa.
NK Cell
Chiwerengero cha anthu:Kupititsa patsogolo thanzi labwino / ukalamba; kupewa opaleshoni ya post-chotupa.
Njira Zofunikira:Pamafunika kukula kwa mu vitro kwa maselo ambiri.
Ubwino:Kuyambitsa mwachangu njira zopha anthu, mitundu yosiyanasiyana ya zotupa.
DC Cell
Chiwerengero cha anthu:Kupewa opaleshoni ya post-chotupa.
Njira Zofunikira:Kutengedwa kuchokera ku autologous peripheral blood.
Ubwino:Kuwonetsa kwamphamvu kwambiri kwa antigen, kujambula kolondola kwa zizindikiro zotupa.
Selo ya CAR-T
Chiwerengero cha anthu:Zotupa za Hematologic, zotupa zina zolimba.
Njira Zofunikira:Kutengedwa kuchokera ku autologous peripheral blood.
Ubwino:Kuzindikiritsa bwino maselo otupa, okhala ndi kukumbukira.
KWA Cell
Kugwiritsa Ntchito Population: Kupewa opaleshoni ya pambuyo pa chotupa.
Njira Zofunikira: Kupeza minofu ya autologous chotupa.
Ubwino: Kupha mwamphamvu, kulowa mosavuta kwa chilengedwe chotupa.
Milandu Yogwiritsa Ntchito Maselo Oteteza Chitetezo
Kupambana kwa Neurotrophic factor therapy kumapereka phindu lowoneka bwino pama cell achitetezo.
Mlandu Woyamba:
Kuwona kwachipatala kukuwonetsa kuti odwala khansa ya m'mapapo ochedwa, pambuyo pa chithandizo cha NK cell, adakwanitsa kuwongolera matenda. Zotsatira zoyeserera zimatsimikizira kuti NK cell immunotherapy ingagwiritsidwe ntchito ngati chithandizo chothandizira pochiza odwala khansa ya m'mapapo mochedwa.
Zoyeserera Zoyeserera: Cholinga chinali kufufuza momwe NK (HANK) cell immunotherapy imagwirira ntchito kwambiri odwala khansa ya m'mapapo. Odwala khumi ndi atatu (8 amuna, 5 akazi) omwe ali ndi zaka zapakati pa 57.3, omwe amapezeka ndi adenocarcinoma (n = 12) kapena squamous cell carcinoma (n = 1), anaphatikizidwa. Magawo IV, III, ndi II adapezeka mu 10, 2, ndi odwala 1 motsatana. Maselo a mononuclear anali olekanitsidwa ndi odwala, ndipo maselo a NK anakulitsidwa.
Kagwiritsidwe: Wodwala aliyense adalandira kosi imodzi (maphunziro aliwonse anali ndi ma infusions atatu, kulowetsedwa kulikonse kumakhala mkati mwa mphindi 30). pamwezi mankhwala sanali upambana maphunziro atatu. Maphunziro aliwonse amaphatikizapo kulowetsedwa katatu kotsatizana, kwa masiku atatu (pafupifupi 3-5 × 10 ^ Maselo a HANK 9 anasonkhanitsidwa mu thumba la magazi tsiku lililonse, ndi kulowetsedwa kwa 2 × 10 ^ 7 / mL). Ma subsets a Lymphocyte, kupanga cytokine, ndi kufotokoza kwa carcinoembryonic antigen (CEA) ndi thymidine kinase 1 (TK1) adayesedwa asanalandire chithandizo komanso atatha kulowetsedwa komaliza.
Results: Palibe zotsatira zoyipa zomwe zidawonedwa. Pambuyo pakutsatiridwa kwa miyezi ya 3, chiwerengero cha odwala omwe ali ndi matenda okhazikika komanso opita patsogolo anali 84.6% ndi 15.4%, motero. Kuphatikiza apo, milingo ya IFN-γ idakula kwambiri pambuyo pa chithandizo, ndipo milingo ya CEA idatsika kwambiri. Chitetezo cha mthupi cha odwala omwe amalandila chithandizo cha NK cell chidakhala chokhazikika.
Mu November 1984, Linda Taylor, mkazi wa US Navy servicewoman ndi advanced metastatic melanoma, adachita nawo mayesero achipatala a chotupa immunotherapy motsogoleredwa ndi Dr. Steven Rosenberg wa National Cancer Institute (NCI). Anapulumuka bwinobwino ndipo anakhala wodwala woyamba kuchiritsidwa ndi Neurotrophic factor therapy.
Mu 2012, Emily Whitehead, wazaka 6, adakhala mwana woyamba padziko lapansi kulandira chithandizo chamankhwala choyesera. Anachita nawo kafukufuku wa University of Pennsylvania pa chithandizo cha CAR-T cha ana acute lymphoblastic leukemia ndipo adapezanso moyo watsopano, akukhala wathanzi mpaka lero.
Pa Epulo 5, 2016, pulogalamu ya CCTV-10 "Kuukitsidwa kwa Maselo a NK" inanena kuti Ms. Tang, wazaka 58 panthawiyo, adakumana ndi moyo wabwino komanso chitetezo chokwanira chifukwa cha kuikidwa magazi kwa NK, ndikuchotsa thanzi lake labwino.
Pambuyo pazaka makumi ambiri akuyesayesa kosalekeza komanso kafukufuku wokangalika ndi mibadwo ingapo ya asayansi, kumvetsetsa kwathu gawo la maselo oteteza chitetezo ku chitetezo chathupi ndikuwunika kufunika kwa ma cell a chitetezo chamthupi mosalekeza kupangitsa kuti ma cell a chitetezo chamthupi azigwira ntchito zambiri.
Timakhulupirira kuti pamene kafukufuku ndi ntchito za maselo a chitetezo cha mthupi zikupitirizabe kuzama, maselo a chitetezo cha mthupi, monga osamalira thanzi laumunthu, adzathandizira chitukuko chapamwamba cha ntchito za thanzi laumunthu.