Chithandizo

Njira yochiritsira ya Stem Cell

Mesenchymal stem cell (MSCs) amapezeka m'magulu osiyanasiyana. Mu 1991, CAPLAN inatchula gulu la maselo omwe amatha kumamatira ku mbale za pulasitiki m'mafupa a mafupa, anali ndi kuchuluka kwakukulu kwa mu vitro, ndipo adawonetsa kusiyana kwakukulu ngati maselo a mesenchymal. Ma MSC ndi mtundu wa maselo akuluakulu amphamvu ochuluka ochokera ku mesoderm. Poyamba olekanitsidwa ndi mafupa, adapezeka m'mafupa osiyanasiyana monga minofu ya chigoba, minofu ya adipose, fupa la mafupa, chingwe cha umbilical, chingwe cha magazi, minofu ya mano, amniotic membrane, ndi placenta.

Maselo a Neuronal Mesenchymal Stem Cells ndi maselo akuluakulu omwe ali ndi mphamvu yodzikonzanso komanso yosiyana kwambiri, yomwe imatha kusiyanitsa mu minofu ndi ziwalo zosiyanasiyana zochokera ku mesoderm. Ngakhale kusiyana kwawo kwakukulu kumakhudza minofu ndi ziwalo zochokera ku mesoderm, kafukufuku wasonyezanso kuthekera kwa MSCs kusiyanitsa mu hepatocytes, neurons, ndi epithelial cell, pakati pa ena, osagwirizana ndi mesoderm.

Lumikizanani nafe

MSCs

Kugwiritsa ntchito ma mesenchymal stem cell (MSCs) kumakhudza magawo awa:

Matenda a Autoimmune System:Matenda a nyamakazi, systemic lupus erythematosus.

Zoyenera Kuchita Opaleshoni:Kuvulala kwa msana, avascular necrosis ya mutu wachikazi, osteoarthritis, etc.

Anti-Kukalamba ndi Zodzikongoletsera:Mokwanira revitalizing pamwamba pa khungu, kukhalabe unyamata mikhalidwe thupi.

Matenda a Endocrine System:Matenda a shuga, zovuta za matenda ashuga, etc.

Matenda a mtima:Myocardial infarction, matenda a mtima, dilated cardiomyopathy, etc.

Matenda a Hematological:Kulimbikitsa kuchira kwa hematopoietic, kukana chitetezo chamthupi, etc.

Matenda a Neurological:Cerebral palsy, Parkinson's disease, sequelae of stroke, etc.

Matenda a m'mimba:Cirrhosis, ulcerative colitis, etc.

Maselo a Neural Stem

Maselo a Neural stem ndi mtundu wapadera wa maselo omwe ali ndi luso lapadera komanso amatha kusiyanitsa mitundu yosiyanasiyana ya ma neurons ndi ma neuroglial. Zimakhala mkati mwa dongosolo lamanjenje laumunthu, kuphatikizapo ubongo, msana, ndi mitsempha ina.

Maselo a Neural stem amatha kudzikonzanso, kugawikana mosalekeza kuti apange maselo atsopano. Amakhalanso ndi mphamvu yosiyanitsa mitundu yosiyanasiyana ya maselo a neural, monga neurons, astrocytes, ndi oligodendrocytes.

Amagwira ntchito yofunika kwambiri pakupanga ndi kukonza dongosolo lamanjenje, kuthandizira kukonza minyewa yomwe yawonongeka komanso kuti minyewa igwire bwino ntchito.

Maselo a Neural stem amakhulupilira kuti amatha kuchiza matenda ena amitsempha ndi kuvulala, monga matenda a Parkinson, kuvulala kwa msana, ndi matenda ena a neurodegenerative. Kuthekera kumeneku kwakopa chidwi chambiri mu kafukufuku wamankhwala.

ndi zina

Ma cell a NK, omwe amadziwikanso kuti Natural Killer Cells, ndi ma lymphocyte akuluakulu ang'onoang'ono ochokera m'mafupa. Iwo amapanga 5% -10% ya okwana lymphocytes mu zotumphukira magazi. Maselowa ndi maselo ofunikira kwambiri a chitetezo chamthupi omwe amatha kuletsa kuukira kwa mabakiteriya ndi ma virus, kuthetsa khansa, ma pathological, ndi ukalamba. Amakhala ndi zotsatira zapadera popewa khansa komanso kuchedwetsa ukalamba ndipo amadziwika ndi azachipatala ngati "njira yoyamba yachitetezo" m'thupi komanso "oyeretsa" magazi.

Makhalidwe a NK Maselo

Chitetezo:Kuchotsa mabakiteriya / ma virus osiyanasiyana komanso kuchotsa ma cell a khansa.
Kukhazikika:Kuchotsa maselo okalamba ndi kukhazikika kagayidwe kake.
Kukhazikika ndi mphamvu za NK cell zimakhudza mwachindunji mphamvu ya thupi yolimbana ndi matenda. Malinga ndi WHO, miyala inayi yotsitsimutsa chitetezo cha mthupi ndi: 70% zakudya + 10% maganizo + 10% zolimbitsa thupi + 10% kupuma. Kuphatikiza apo, kuwonjezera ma cell a NK ndi ma cell ena achitetezo amatha kulimbikitsa ndikuwonjezera chitetezo chamthupi, kukwaniritsa zolinga zachitetezo cha chitetezo chamthupi komanso chithandizo chamankhwala.

Zotsatira Zotsutsa Kukalamba za NK Maselo

Kuchotsa mwachindunji maselo okalamba, kukhazikitsa chotchinga cholimba cha chitetezo chamthupi.

Kuchulukitsa kwa maselo atsopano amphamvu, kumachepetsa kukalamba kwa ziwalo.

Munthawi yomweyo kuwongola ena a chitetezo cha m'thupi ntchito pamene optimizing thupi.

Kulimbana ndi ma cell omwe ali ndi kachilomboka, kuteteza ndi kuchepetsa matenda amtima, endocrine, chiwindi, impso, ndi mitsempha yamanjenje.

Kupititsa patsogolo kwa matenda osatha okhudzana ndi chitetezo chamthupi monga gout, hepatitis, etc.

Kupititsa patsogolo kukumbukira ndi ntchito yachidziwitso.

Kuchepetsa kutopa, kuchuluka kwa mphamvu ndi mphamvu.

Kuchepetsa nkhawa zamalingaliro, kugona bwino, komanso kukhazikika kwamalingaliro.

ZINGATI

CIK therapy ndi njira yochizira ma cell a chitetezo chamthupi yomwe imakulitsa ndikuyambitsa ma cell a chitetezo chamthupi, monga ma Cytokine-Induced Killer cell, kuti athe kupha ma cell chotupa. Maselo a CIK amapezedwa popanga maselo kuchokera m'magazi a wodwalayo, omwe amalowetsedwa m'thupi la wodwalayo.

Kuchuluka kwa ntchito: CIK therapy imagwiritsidwa ntchito pochiza khansa, makamaka kwa odwala khansa yapakatikati monga khansa ya m'mapapo, khansa ya m'mawere, khansa ya m'mimba, khansa ya chiwindi, ndi zina zotero. , potero kupititsa patsogolo zotsatira za chithandizo ndi kuchuluka kwa moyo.

PRP

PRP ndi mankhwala opangidwa ndi mapulateleti omwe amatengedwa m'magazi a wodwalayo pogwiritsa ntchito njira monga centrifugation. Lili ndi zinthu zambiri za kukula ndi mapuloteni omwe amathandizira kukonza minofu, kusinthika, kuchira kwa bala, ndi kukonza minofu yofewa. PRP imagwiritsidwa ntchito kwambiri pazamankhwala kulimbikitsa machiritso a bala, machiritso osweka, komanso maopaleshoni odzikongoletsa.

Kuchuluka kwa ntchito: PRP imagwiritsidwa ntchito makamaka mu orthopedics, opaleshoni ya pulasitiki, mano, pakati pa magawo ena. Amagwiritsidwa ntchito pochiza kuvulala kwa minofu ndi mafupa, tendonitis, kuvulala kwa cartilage, mabala osatha, kuthandizira kupititsa patsogolo zotsatira za chithandizo ndikufulumizitsa kuchira.