Ibyiringiro bishya kubarwayi ba kanseri: Ikipe ya Harvard itezimbere urukingo rwa DC super-Activator

Intangiriro

Mugihe tugenda dusaza, imikorere yumubiri yumubiri igenda igabanuka buhoro buhoro, bigatuma yandura virusi na bagiteri, mugihe kanseri yiyongera cyane. Ubushakashatsi bwerekanye ko bibiri bya gatatu bya kanseri zimaze kugaragara zibaho ku bantu bafite imyaka 60 no hejuru yayo. Ibi byerekana isano ya hafi hagati yubudahangarwa no gusaza. Niba dushobora kongera ubudahangarwa bw'umubiri mubantu bageze mu zabukuru, bizagira ingaruka nziza kubuzima bwabo muri rusange.

Ku ya 12 Kamena 2024, itsinda rya Porofeseri Jonathan C. Kagan wo mu Ishuri Rikuru ry’Ubuvuzi rya Harvard ryasohoye urupapuro rwiswe "Gukosora inenge ziterwa n’imyaka mu ngirabuzimafatizo ya dendritic ituma selile CD4 + T kurandura ibibyimba" mu kinyamakuru * Akagari *. Iyi ngingo igaragaza ko mu kwivanga mu bikorwa bya selile dendritic, bishoboka gukosora intege nke z’umubiri ziterwa n’imyaka, bityo bikongerera ubushobozi ingirabuzimafatizo za CD4 + T zo gukuraho ibibyimba. Ibi bitanga uburyo bushya bwo gukingira kanseri kubasaza.

Gutohoza Ingaruka zimyaka ku ngaruka za Kanseri Immunotherapy

Itsinda ry’ubushakashatsi ryabanje gukoresha imiterere yimbeba ya melanoma hanyuma ivura imbeba hakoreshejwe PD-1 na CTLA4 ikingira ikibyimba kugirango isuzume imbaraga zubushobozi bwumubiri urwanya kanseri ku mbeba zimyaka itandukanye. Basanze mugihe ibibyimba byimbeba zikiri nto bishobora kuvurwa, ibibyimba byimbeba zishaje ntibishobora kurandurwa. Ibi bisubizo byahujwe nubushobozi bubiri buzwi bujyanye n’ubudahangarwa bw'umubiri: igabanuka rya sisitemu mu mubare w'utugingo ngengabuzima T na selile dendritic selile (DC).

Ingirabuzimafatizo (DC) zitwa amazina ya dendritic projection zigenda zikura. Zifite uruhare runini muri sisitemu yumubiri ivuka kandi ihindagurika kandi ni selile zikomeye zerekana antigen. DC zifite ubushobozi bwo gukangura selile naive T kugirango itangire gukingira umubiri.

Iri tsinda ryashyizeho urukingo rwa DC selile super-activator, rushobora gukosora ubudahangarwa bw'umubiri ku mbeba zishaje.

Ubushakashatsi bwerekanye ko imikorere mibi ya selile DC ishobora kuba ishingiro ryo kubura kwirwanaho byagaragaye mubantu bageze mu zabukuru. Kubera iyo mpamvu, abashakashatsi bakoze DC super-activateur nkurukingo rwinkingo. Iyi miti irashobora gukosora inenge yimuka ya selile ya DC mu mbeba zishaje, igatera ibikorwa bya cytolytike muri selile T umufasha 1 (TH1) CD4 + T, kandi ikongerera ubudahangarwa bw'umubiri kurwanya imbeba zishaje.

Kugenzura ibikorwa by'akagari ka DC bihindura imyaka ijyanye no kubura Immune

Ibisubizo byubushakashatsi byerekana ko dushobora gukosora intege nke ziterwa n’imyaka dukoresheje ibikorwa bya selile dendritic, byerekana ko ubudahangarwa bw'umubiri ku baturage bageze mu zabukuru bushobora guhinduka. Ibi bifite uruhare runini mu kuzamura imibereho yubusaza kandi byerekana intambwe igaragara muri immunotherapie ya kanseri kuriyi myaka.

Ingirabuzimafatizo ya Dendritic, nka sentinels ya sisitemu yumubiri, igira uruhare runini mu kuvura kanseri. Barashobora gukora neza no kuyobora selile T kumenya no gusenya kanseri ya kanseri, bityo bagatangiza ubudahangarwa bw'umubiri urwanya umubiri.

Reba

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Gukosora inenge ziterwa nimyaka muri selile dendritic ituma selile CD4 + T kurandura ibibyimba. Akagari. 2024 Nyakanga 25; 187 (15): 3888-3903.e18. doi: 10.1016 / j.cell.2024.05.026.

Gukosora inenge ziterwa nimyaka muri selile dendritic ituma selile CD4 + T kurandura ibibyimba

Akagari

NIBA: 41.584

2024.6.12

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