Kalafo
Phekolo e tsoetseng pele ea Neurotrophic factor
Lisele tsa 'mele tsa ho itšireletsa mafung ke eng?
Lisele tsa 'mele tsa ho itšireletsa mafung li bua ka sehlopha' meleng oa motho se khethehileng ka "ts'ireletso." Ka tloaelo e tsejoa e le lisele tse tšoeu tsa mali, lisele tsa 'mele tsa ho itšireletsa mafung li kenyelletsa li-lymphocyte tse sa tšoaneng le li-phagocyte tse ka khonang ho lemoha le ho felisa li-antigen, ho kenya letsoho likarabong tsa' mele oa ho itšireletsa mafung. ’Mele ea rōna e tšoana le naha e ikemetseng, ’me tsamaiso ea ’mele ea ho itšireletsa mafung e sebetsa e le sesole sa rōna le mapolesa. Ha e sebetse feela e le sesole ho tsebahatsa le ho felisa likokoana-hloko tse hlaselang empa hape e sebetsa joalo ka mapolesa ho lemoha le ho felisa lisele tse fetotsoeng, tse shoang, kapa lintho tse ling tse kotsi ka har'a 'mele.
Mesebetsi ea lisele tsa 'mele
Ho matlafatsa Tšireletso:Ho kenya tšebetsong sesole sa 'mele ho ntlafatsa bokhoni ba ho loants'a livaerase le libaktheria.
Ho Ntlafatsa Bophelo bo Botle bo Botle:Ho laola sesole sa 'mele ho hanela tšoaetso le livaerase, ho ntlafatsa bokhoni ba metabolic ea lisele, le ho ntlafatsa bophelo bo botle ka botlalo.
Anti-Botsofali:Ho khothaletsa metabolism, ho tlosa kapele lisele tse shoeleng le tse tsofetseng ho lieha ho tsofala.
Thibelo le Kalafo ea Mofets'e:Ho matlafatsa matla a 'mele a ho hanela lihlahala, ho hlakola lisele tse fetotsoeng ka nako, kahoo ho thibela le ho hlasela lisele tsa hlahala.
NK sele
Baahi ba Sebeletsang:ho ntlafatsa bophelo bo botle / botsofali ba pele; thibelo ea ho buuoa ka mor'a hlahala.
Mehato ea Bohlokoa:E hloka katoloso ea in vitro ea lisele tse ngata.
Melemo:Ho qala ka potlako mekhoa ea ho bolaea, mefuta e mengata ea lihlahala.
DC Cell
Baahi ba Sebeletsang:Thibelo ea ho buuoa ka mor'a hlahala.
Mehato ea Bohlokoa:Pokello ho tsoa maling a autologous peripheral.
Melemo:Tlhahiso e matla ka ho fetisisa ea antigen, ho ts'oaroa ka nepo ha matšoao a hlahala.
CAR-T sele
Baahi ba Sebeletsang:Lihlahala tsa Hematologic, lihlahala tse itseng tse tiileng.
Mehato ea Bohlokoa:Pokello ho tsoa maling a autologous peripheral.
Melemo:Khethollo e nepahetseng ea lisele tsa tumor, tse nang le mohopolo.
HO Seleng
Baahi ba sebetsang: Thibelo ea ho buuoa ka mor'a hlahala.
Mehato ea Bohlokoa: Ho fumana lisele tsa autologous tumor.
Melemo: Bokhoni bo matla ba ho bolaea, ho kenella habonolo ha tikoloho ea hlahala.
Maemo a Tšebeliso ea Lisele Tsa Tšireletso ea 'mele
Katleho ea Neurotrophic factor therapy e fana ka boleng bo bonahalang haholoanyane liseleng tsa 'mele.
Taba ea Pele:
Litlhahlobo tsa bongaka li bontša hore bakuli ba kankere ea matšoafo ba morao-rao, ka mor'a phekolo ea NK cell, ba fihletse taolo e tsitsitseng ea mafu. Liphetho tsa liteko li paka hore NK cell immunotherapy e ka sebelisoa e le kalafo ea adjuvant kalafong ea bakuli ba mofetše oa matšoafo.
Semelo sa Teko: Sepheo e ne e le ho hlahloba katleho ea NK (HANK) cell immunotherapy e sebelisoang haholo ho bakuli ba mofetše oa matšoafo. Bakuli ba leshome le metso e meraro (banna ba 8, basali ba 5) ba nang le lilemo tse mahareng tsa lilemo tsa 57.3, ba fumanoeng ba e-na le adenocarcinoma (n = 12) kapa squamous cell carcinoma (n = 1), ba kenyelelitsoe. Mehato ea IV, III, le II e fumanoe ho bakuli ba 10, 2, le 1, ka ho latellana. Lisele tsa mononuclear li ne li arohane le bakuli, 'me lisele tsa NK li ile tsa atolosoa.
Tšebeliso: Mokuli e mong le e mong o ile a fumana bonyane thupelo e le 'ngoe (thupelo e' ngoe le e 'ngoe e ne e kenyelletsa li-infusions tse tharo, 'me e' ngoe le e 'ngoe e tšoarella nakong ea metsotso e 30). Liphekolo tsa khoeli le khoeli ha lia ka tsa feta lithuto tse tharo. Koetliso e 'ngoe le e' ngoe e ne e kenyelletsa li-infusions tse tharo tse latellanang, tse nkang matsatsi a mararo (hoo e ka bang 3-5 × 10 ^ 9 HANK lisele li ne li bokelloa ka mokotleng oa tšelo ea mali letsatsi le leng le le leng, tse nang le infusion concentration ea hoo e ka bang 2 × 10 ^ 7 / mL). Li-subsets tsa lymphocyte, tlhahiso ea cytokine, le polelo ea carcinoembryonic antigen (CEA) le thymidine kinase 1 (TK1) li ile tsa lekanyetsoa pele ho phekolo le ka mor'a ho tšeloa ho qetela.
Results: Ha ho litla-morao tse ileng tsa bonoa. Ka mor'a ho latela likhoeli tsa 3, palo ea bakuli ba nang le lefu le tsitsitseng le e tsoelang pele e ne e le 84.6% le 15.4%, ka ho latellana. Ho phaella moo, litekanyetso tsa IFN-γ li ile tsa eketseha haholo ka mor'a phekolo, 'me maemo a CEA a fokotseha haholo. Kakaretso ea ts'ebetso ea 'mele ea ho itšireletsa mafung ea bakuli ba fumanang NK cell therapy e ile ea lula e tsitsitse.
Ka November 1984, Linda Taylor, mosali oa sesole sa US Navy ea nang le melanoma e tsoetseng pele ea metastatic, o ile a kenya letsoho tekong ea bongaka ea tumor immunotherapy e etelletsoeng ke Dr. Steven Rosenberg oa National Cancer Institute (NCI). O ile a pholoha ka katleho 'me ea e-ba mokuli oa pele lefatšeng ea ileng a phekoloa ke Neurotrophic factor therapy.
Ka 2012, Emily Whitehead ea lilemo li 6 e bile ngoana oa pele oa lefats'e oa ho fumana kalafo ea lisele tsa liteko. O ile a kenya letsoho thutong ea Univesithi ea Pennsylvania mabapi le phekolo ea CAR-T bakeng sa bongoana acute lymphoblastic leukemia 'me a boela a phela bophelo bo botle ho fihlela kajeno.
Ka la 5 April, 2016, lenaneo la CCTV-10 "Resurrected NK Cells" le tlalehile hore Mofumahali Tang, ea lilemo li 58 ka nako eo, o ile a ba le matla a ntlafetseng le ho itšireletsa mafung ka ho tšeloa ha lisele tsa NK, ho felisa boemo ba hae ba bophelo bo botle.
Ka mor'a mashome a lilemo a boiteko bo sa khaotseng le lipatlisiso tse matla tsa meloko e mengata ea bo-rasaense, kutloisiso ea rona ea karolo ea lisele tsa 'mele tsa ho itšireletsa mafung le ho hlahloba bohlokoa ba lisele tsa' mele oa 'mele oa ho itšireletsa mafung li tsoela pele ho thusa lisele tsa 'mele tsa ho itšireletsa mafung hore li bapale likarolo tse ngata.
Re lumela hore ha lipatlisiso le ts'ebeliso ea lisele tsa 'mele tsa ho itšireletsa mafung li ntse li tsoela pele ho teba, lisele tsa' mele tsa 'mele, e le bahlokomeli ba bophelo bo botle ba batho, li tla kenya letsoho ntlafatsong ea boleng bo phahameng ba boiteko ba bophelo ba batho.