Kalafo

Mekhoa e mecha ea phekolo ea Stem Cell

Mesenchymal stem cell (MSCs) e teng ka har'a lisele tse fapaneng. Ka 1991, CAPLAN e ile ea reha sehlopha sa lisele tse ka khomarelang lipoleiti tsa setso tsa polasetiki mokong oa masapo, li ne li e-na le keketseho e phahameng ea in vitro, 'me li bontšitse phapang e ngata e le lisele tsa mesenchymal stem. Li-MSC ke mofuta oa lisele tsa batho ba baholo tse nang le matla a mangata tse tsoang ho mesoderm. Qalong li arohane le moko oa masapo, hamorao li fumanoe ka har'a lisele tse fapaneng tse kang mesifa ea masapo, lisele tsa adipose, moko oa masapo, mokhubu, mali a thapo, lisele tsa meno tse hlabang, lesela la amniotic le placenta.

Neuronal Mesenchymal Stem Cells ke lisele tsa stem tsa batho ba baholo tse nang le bokhoni ba ho inchafatsa le ho fapana ka matla a mangata, tse khonang ho ikarola ka har'a lisele tse fapaneng le litho tse nkiloeng ho mesoderm. Leha phapang ea bona ea mantlha e kenyelletsa lisele le lisele tsa setho tse tsoang mesoderm, lithuto li boetse li bonts'itse bokhoni ba li-MSC ho ikarola ho li-hepatocyte, neurons, le lisele tsa epithelial, hara tse ling, tse sa amaneng le mesoderm.

Iteanye le rona

Li-MSC

Ts'ebeliso ea lisele tsa mesenchymal stem (MSCs) e akaretsa libaka tse latelang:

Mafu a Autoimmune System:Systemic lupus erythematosus, ramatiki ea ramatiki.

Maemo a Opereishene:Kotsi ea mokokotlo, avascular necrosis ea hlooho ea botšehali, osteoarthritis, joalo-joalo.

Anti-botsofali le Cosmetic:Ho tsosolosa ka ho feletseng holim'a letlalo, ho boloka maemo a 'mele oa bacha.

Maloetse a Sisteme ea Endocrine:Lefu la tsoekere, mathata a lefu la tsoekere, joalo-joalo.

Mafu a pelo:Myocardial infarction, lefu la pelo, dilated cardiomyopathy, joalo-joalo.

Mathata a Hematological:Ho khothaletsa ts'ebetso ea hematopoietic, ho hana ho hanyetsa 'mele, joalo-joalo.

Mathata a Neurological:Cerebral palsy, lefu la Parkinson, sequelae ea stroke, joalo-joalo.

Mafu a Gastrointestinal:Cirrhosis, ulcerative colitis, joalo-joalo.

Lisele tsa Neural Stem

Lisele tsa Neural stem ke mofuta o ikhethileng oa sele e nang le bokhoni bo ikhethang le bokhoni ba ho ikarola ka mefuta e fapaneng ea li-neurone le lisele tsa neuroglial. Li teng ka har'a tsamaiso ea methapo ea motho, ho kenyelletsa boko, lesapo la mokokotlo le lisele tse ling tsa methapo.

Lisele tsa Neural stem li na le bokhoni ba ho inchafatsa, li lula li arohana ho hlahisa lisele tse ncha tsa stem. Li boetse li na le bokhoni ba ho ikarola ka mefuta e fapaneng ea lisele tsa methapo, joalo ka li-neuron, astrocyte le oligodendrocyte.

Li bapala karolo ea bohlokoa ntlafatsong le tlhokomelong ea tsamaiso ea methapo, li thusa ho lokisa lisele tse senyehileng tsa methapo le ho boloka tšebetso e tloaelehileng ea methapo.

Lisele tsa Neural stem ho lumeloa hore li na le ts'ebeliso ea kalafo bakeng sa maemo a itseng a methapo le likotsi, joalo ka lefu la Parkinson, likotsi tsa lesapo la mokokotlo, le mafu a itseng a neurodegenerative. Bokhoni bona bo hohetse tlhokomelo e atileng liphuputsong tsa bongaka.

etc

Lisele tsa NK, tse tsejoang hape e le Natural Killer Cells, ke li-lymphocyte tse kholo tsa granular tse tsoang mokong oa masapo. Li etsa 5% -10% ea kakaretso ea lymphocyte maling a peripheral. Lisele tsena ke lisele tsa bohlokoa tsa 'mele tsa ho itšireletsa mafung tse ka thibelang tlhaselo ea baktheria le vaerase, ho felisa lisele tse nang le mofetše, pathological le botsofali. Li na le litlamorao tse ikhethang tsa ho thibela mofetše le ho liehisa botsofali 'me li tsejoa ke sechaba sa bongaka e le "moeli oa pele oa tšireletso"' meleng le "bahlokomeli" ba mali.

Litšobotsi tsa NK Lisele

Tshireletso:Ho felisa libaktheria / livaerase tse fapaneng tse hlaselang le ho tlosa lisele tsa pathological / mofets'e.
Botsitso:Ho tlosa lisele tse tsofetseng le ho tsitsisa metabolism e tloaelehileng.
Ho tsitsa le matla a lisele tsa NK ka ho toba li ama matla a 'mele a ho loantša maloetse. Ho ea ka WHO, likhutlo tse 'nè tsa ho tsosolosa sesole sa' mele ke: 70% phepo e nepahetseng + 10% boemo ba kelello + 10% boikoetliso + 10% phomolo. Ho phaella moo, ho tlatsana le lisele tsa NK le lisele tse ling tsa 'mele tsa ho itšireletsa mafung li ka susumetsa ka ho toba le ho ntlafatsa ts'ebetso ea' mele ea ho itšireletsa mafung, ho finyella lipakane tsa ho itšireletsa mafung le ho phekola.

Liphello Tse Khahlanong le Botsofali tsa NK Lisele

Ho felisoa ka ho toba ha lisele tsa botsofali, ho theha thibelo e matla ea ho itšireletsa mafung.

Keketso ea lisele tse ncha tse matla, e fokotsang botsofali ba setho.

Ntlafatso ea nako e le 'ngoe ea tšebetso ea lisele tse ling tsa' mele ha o ntse o ntlafatsa 'mele.

Ho loantša lisele tse tšoaelitsoeng ke kokoana-hloko, ho thibela le ho fokotsa mafu a pelo, endocrine, sebete, liphio le tsamaiso ea methapo.

Ntlafatso ea mafu a sa foleng a amanang le boits'ireletso ba mmele joalo ka gout, hepatitis, jj.

Ntlafatso ea mohopolo le ts'ebetso ea kelello.

Ho fokotseha ha mokhathala, matla a eketsehileng le matla.

Ho fokotseha ha matšoenyeho a kelello, boroko bo ntlafetseng, le botsitso ba maikutlo.

BOKAE

Phekolo ea CIK ke mokhoa oa kalafo oa lisele tsa 'mele oa ho itšireletsa mafung o ntlafatsang le ho kenya tšebetsong lisele tsa sesole sa 'mele tsa mokuli, joalo ka lisele tsa Cytokine-Induced Killer, ho matlafatsa bokhoni ba tsona ba ho bolaea lisele tsa tumor. Lisele tsa CIK li fumanoa ka ho hlahisa lisele tse tsoang maling a peripheral a mokuli, ebe li kenngoa hape 'meleng oa mokuli.

Sebaka sa kopo: Phekolo ea CIK e atisa ho sebelisoa kalafo ea mofets'e, haholo-holo ho bakuli ba mofets'e oa boemo bo phahameng joalo ka mofets'e oa matšoafo, mofets'e, mofets'e oa mpa, mofets'e oa sebete, joalo-joalo Mosebetsi oa eona ke ho matlafatsa sesole sa 'mele ho loantša le ho felisa lisele tsa mofetše. , ka hona ho ntlafatsa liphello tsa phekolo le litekanyetso tsa ho pholoha.

PRP

PRP ke ntho e nang le platelet e ngata e nkiloeng maling a mokuli ho sebelisoa mekhoa e kang centrifugation. E na le lintlha tse ngata tsa khōlo le liprotheine tse khothalletsang ho lokisoa ha lisele, ho nchafala, ho folisa maqeba le ho lokisa lisele tse bonolo. PRP e atisa ho sebelisoa meriana ho khothalletsa pholiso ea maqeba, pholiso ea ho robeha, le ho buuoa ka litlolo.

Sebaka sa kopo: PRP e sebelisoa haholo-holo ho orthopedics, opereishene ea polasetiki, bongaka ba meno, har'a masimo a mang. E sebelisetsoa ho phekola maqeba a mesifa le masapo, tendonitis, likotsi tsa lefufuru, maqeba a sa foleng, ho thusa ho ntlafatsa liphello tsa phekolo le ho potlakisa ho hlaphoheloa.