M Lupus Gudanarwa

Ba a bayyana ainihin dalilin SLE ba, amma an yi imanin hulɗar tsakanin kwayoyin halitta da abubuwan muhalli suna taka muhimmiyar rawa. Rashin kunna tsarin rigakafi mara kyau yana haifar da hare-haren autoimmune, wanda ke haifar da lalacewa ga kyallen jikin jiki da gabobin jiki.

Abubuwan Halitta:SLE yana kula da gudana a cikin iyalai, kuma dangin marasa lafiya suna da haɓaka mafi girma idan aka kwatanta da yawan jama'a. Abin da ya faru a cikin tagwaye iri ɗaya ya fi girma fiye da na tagwaye, yana nuna dangantaka tsakanin SLE da kwayoyin halitta.

Abubuwan Muhalli:
Hasken rana: Marasa lafiya na SLE sukan fuskanci kumburin cututtuka bayan fitowar rana, maiyuwa saboda ultraviolet-induced cell apoptosis wanda ke haifar da bayyanar antigen.

Magunguna da Ma'aikatan Sinadarai: Antigens na waje na iya kunna tsarin rigakafi, yana haifar da samar da autoantibody da lalacewar nama. Magunguna kamar procainamide, hydralazine, quinidine, da sauransu na iya haifar da SLE.
Kamuwa da cuta: ƙwayoyin cuta masu cutarwa (kamar cytomegalovirus, cutar hanta ta C, cutar Epstein-Barr, da sauransu) suna yin kama da kwayoyi, galibi suna haifar da samar da ƙwayoyin cuta ta hanyar rigakafi.

Estrogen: Yawancin nau'in SLE sun fi yawa a cikin matan da suka kai shekarun haihuwa. Ciki da kuma amfani da magungunan da ke ɗauke da isrogen (kamar maganin hana haihuwa) na iya ƙara tsananta cutar. Gwaje-gwajen dabba sun nuna cewa estrogen yana kara yawan lupus a cikin dabbobin da aka shafa, yayin da testosterone ke rage alamun bayyanar cututtuka, yana nuna kusanci tsakanin matakan estrogen da farkon SLE.

Abubuwan bayyanar asibiti na SLE sun bambanta kuma sun haɗa, amma ba'a iyakance ga:

Alamomin Fatar: Rashes, kurjin fuska mai siffar malam buɗe ido (ƙunƙarar zazzabin cizon sauro), ɗaukar hoto, da sauransu.

Alamomin haɗin gwiwa: Arthritis, ciwon haɗin gwiwa, kumburin haɗin gwiwa.

Alamun Renal: Proteinuria, hematuria, wanda zai iya haifar da nephritis.

Alamomin zuciya: Pericarditis, lalacewar zuciya valvular.

Alamomin Tsarin Jijiya ta Tsakiya: Ciwon kai, kamewa, rashin fahimta.

Binciken SLE ya ƙunshi matakai da yawa:

Shawara: Likita yana tambaya game da manyan alamomi, alamomi masu alaƙa, tsawon lokaci, binciken da aka yi a baya, jiyya, tarihin iyali, da sauransu.

Jarrabawar Jiki: Cikakken jarrabawa da kima na jiki, gami da fata, gashi, rami na baki, da haɗin gwiwa, da sauransu.

Gwaje-gwaje masu dacewa: Gwaje-gwajen jini, nazarin fitsari, nazarin hoto, biopsies na koda, da dai sauransu. Ciwon koda ya ƙunshi ƙaramin aikin tiyata inda aka sami ɗan ƙaramin ƙwayar koda a ƙarƙashin maganin sa barci na gida don gwajin cututtuka da rigakafi.

Baya ga raunukan fata na yau da kullun, binciken histopathological da gwaje-gwajen jini suna zama shaidar ganowa. Binciken Immunopathological yana da daraja sosai a cikin ganewar asali. Ingantattun magungunan autoantibodies, irin su anti-nuclear antibodies (ANA), anti-dsDNA antibodies, anti-Sm antibodies, da dai sauransu, suna da halaye. Canje-canje a cikin titers na antibody na iya yin nuni da ayyukan cututtuka, kuma marasa lafiya na SLE masu aiki sukan nuna haɓakar ƙwayar erythrocyte sedimentation. Binciken fitsari na iya nuna proteinuria, ja/farin jini, da simintin salula.