Umuti
Ubuvuzi buhanitse bwa Neurotrophique
Ingirabuzimafatizo ni iki?
Immune selile bivuga itsinda mumubiri wumuntu kabuhariwe "kwirwanaho." Ubusanzwe izwi nka selile yamaraso yera, selile immunite zirimo lymphocytes zitandukanye na fagocytes zishobora kumenya no gukuraho antigene, zikagira uruhare mubisubizo byubudahangarwa. Umubiri wacu umeze nkigihugu cyigenga, kandi sisitemu yumubiri itubera igisirikare nigipolisi. Ntabwo ikora nkigisirikare gusa kugirango imenye kandi ikureho virusi itera ariko kandi ikora nka polisi kugirango imenye kandi ikureho ingirabuzimafatizo zahinduwe, zipfa, cyangwa ibindi bintu byangiza umubiri.
Imikorere ya selile selile
Kongera ubudahangarwa:Gukora sisitemu yumubiri kugirango utezimbere ubushobozi bwo kurwanya virusi na bagiteri.
Gutezimbere Ubuzima Bwuzuye:Kugenga sisitemu yumubiri kugirango irwanye kwandura na virusi, kunoza ubushobozi bwimikorere ya selile, no kuzamura ubuzima muri rusange.
Kurwanya gusaza:Guteza imbere metabolism, guhita ukuraho ingirabuzimafatizo zapfuye kandi zishaje kugirango utinde gusaza.
Kurinda Kanseri no Kuvura:Gushimangira ubushobozi bwumubiri bwo kurwanya ibibyimba, gukuraho ingirabuzimafatizo zahinduwe ku gihe, bityo bikarinda no gutera ingirabuzimafatizo.
Akagari ka NK
Abaturage bakoreshwa:Gutezimbere ubuzima budasanzwe / gusaza hakiri kare; kwirinda nyuma yo kubagwa.
Intambwe z'ingenzi:Irasaba muri vitro kwagura umubare munini wingirabuzimafatizo.
Ibyiza:Gutangiza byihuse uburyo bwo kwica, ubwinshi bwubwoko bwibibyimba.
Akagari ka DC
Abaturage bakoreshwa:Kwirinda nyuma yo kubyimba.
Intambwe z'ingenzi:Icyegeranyo kiva mumaraso ya autologique.
Ibyiza:Ikimenyetso gikomeye cya antigen, gufata neza ibimenyetso byibibyimba.
CAR-T Akagari
Abaturage bakoreshwa:Ibibyimba bya Hematologic, ibibyimba bimwe bikomeye.
Intambwe z'ingenzi:Icyegeranyo kiva mumaraso ya autologique.
Ibyiza:Kumenya neza selile yibibyimba, bifite kwibuka.
KU Kagari
Abaturage bakoreshwa: Kwirinda nyuma yo kubyimba.
Intambwe z'ingenzi: Kubona ibibyimba bya autologique.
Ibyiza: Ubushobozi bukomeye bwo kwica, kwinjira byoroshye kubyimba microen ibidukikije.
Gusaba Imanza Zingirangingo
Intsinzi yubuvuzi bwa Neurotrophique itanga agaciro kagaragara kumasemburo yumubiri.
Urubanza rwa mbere:
Ubushakashatsi bwakozwe bwerekana ko abarwayi ba kanseri y'ibihaha batinze, nyuma yo kuvura selile NK, bageze ku kurwanya indwara zihamye. Ibisubizo byubushakashatsi byerekana ko immunoterapi ya NK ishobora gukoreshwa nkubuvuzi bujyanye no kuvura abarwayi ba kanseri y'ibihaha bitinze.
Ubushakashatsi bwibanze: Icyari kigamijwe kwari ugushaka kumenya imikorere ya immunoterapi ya NK (HANK) ikora cyane ku barwayi ba kanseri y'ibihaha. Harimo abarwayi 13 (abagabo 8, abagore 5) bafite hagati yimyaka 57.3, basuzumwe na adenocarcinoma (n = 12) cyangwa kanseri y'udukoko twa kanseri (n = 1). Icyiciro cya IV, III, na II byagaragaye ku barwayi 10, 2, na 1. Ingirabuzimafatizo za Monon nuclear zitandukanijwe n’abarwayi, kandi selile NK yaguwe.
Ikoreshwa: Buri murwayi yakiriye byibuze isomo rimwe (buri somo ryarimo inshuro eshatu, hamwe na buri gushiramo kumara iminota 30). Kuvura buri kwezi ntibyarenze amasomo atatu. Buri somo ryarimo inshuro eshatu zikurikiranye, zimara iminsi itatu (hafi 3-5 × 10 ^ 9 HANK selile yakusanyirizwaga mumufuka wo guterwa buri munsi, hamwe no gushiramo hafi 2 × 10 ^ 7 / mL). Lymphocyte subets, umusaruro wa cytokine, hamwe no kwerekana antigen ya karcinoembryonic (CEA) na thymidine kinase 1 (TK1) byapimwe mbere yo kuvurwa na nyuma yo gushiramo bwa nyuma.
Ibisubizo: Nta ngaruka mbi zagaragaye. Nyuma y’amezi 3 yakurikiranwe, umubare w’abarwayi bafite indwara zihamye kandi zigenda ziyongera ni 84,6% na 15.4%. Byongeye kandi, urwego IFN-γ rwiyongereye cyane nyuma yo kuvurwa, kandi urwego rwa CEA rwaragabanutse cyane. Imikorere rusange yubudahangarwa bwabarwayi bahabwa imiti ya NK yagumye ihagaze neza.
Mu Gushyingo 1984, Linda Taylor, umutegarugori w’ingabo z’Amerika zirwanira mu mazi ufite melanoma yateye imbere, yagize uruhare mu igeragezwa ry’amavuriro y’ikingira ry’ibibyimba riyobowe na Dr. Steven Rosenberg wo mu kigo cy’igihugu gishinzwe kanseri (NCI). Yarokotse neza maze aba umurwayi wa mbere ku isi wakize na Neurotrophique factor therapy.
Mu mwaka wa 2012, Emily Whitehead w'imyaka 6 y'amavuko abaye umwana wa mbere ku isi wakorewe imiti igerageza. Yitabiriye ubushakashatsi muri kaminuza ya Pennsylvania ku buvuzi bwa CAR-T bwo kuvura indwara ya lymphoblastique ikaze yo mu bwana kandi agarura ubuzima bushya, abaho neza kugeza na n'ubu.
Ku ya 5 Mata 2016, gahunda ya CCTV-10 "Akagari ka NK yazutse" yatangaje ko Madamu Tang, wari ufite imyaka 58 icyo gihe, yagize ubuzima bwiza ndetse anongera ubudahangarwa bw'umubiri binyuze mu guterwa akagari ka NK, bikuraho ubuzima bwe budasanzwe.
Nyuma yimyaka ibarirwa muri za mirongo imbaraga zidacogora nubushakashatsi bwakozwe nabasekuruza benshi b'abahanga, gusobanukirwa n'uruhare rw'uturemangingo tw’umubiri no gukora ubushakashatsi ku kamaro k’amavuriro y’ingirabuzimafatizo bikomeza gutuma ingirabuzimafatizo zigira uruhare runini.
Twizera ko uko ubushakashatsi nogukoresha ingirabuzimafatizo zikomeza kwiyongera, ingirangingo z'umubiri, nk'abashinzwe ubuzima bw'abantu, zizagira uruhare mu iterambere ryiza ry’ibikorwa by’ubuzima bwa muntu.