Tariro Itsva yeVarwere Vegomarara: Chikwata cheHarvard Chinogadzira DC Super-Activator Vaccine

Nhanganyaya

Sezvo isu tichikura, immune system yemuviri inodzikira zvishoma nezvishoma, zvichiita kuti ive nyore kutapukirwa nemavhairasi uye mabhakitiriya, nepo chiitiko chegomarara chichiwedzera zvakanyanya. Tsvagiridzo yakawana kuti pamusoro pezvikamu zviviri muzvitatu zvekenza ichangobva kuwanikwa inowanikwa muvanhu vane makore makumi matanhatu zvichikwira. Izvi zvinoratidza hukama hwepedyo pakati pekudzivirira uye kuchembera. Kana tikakwanisa kusimudzira immune system muhuwandu hwevanhu vakura, ichava nemhedzisiro yakanaka pahutano hwavo hwese.

Musi waChikumi 12, 2024, timu yaProfessor Jonathan C. Kagan kubva kuHarvard Medical School yakaburitsa bepa rine musoro unoti "Kugadziriswa kwezvakaremara zvinoenderana nezera mumasero edendritic zvinoita kuti CD4+ T masero abvise mabundu" mujenari *Cell*. Chinyorwa chacho chinoratidza kuti nekupindira mubasa remasero e dendritic, zvinokwanisika kugadzirisa kusakwana kwezera rekudzivirira muviri, nekudaro kunowedzera kukwanisa kweCD4 + T masero kuti abvise mapundu. Izvi zvinopa nzira itsva yekenza immunotherapy kune vakwegura.

Kuongorora Impact yeZera paKushanda kweCancer Immunotherapy

Chikwata chekutsvagisa chakatanga kushandisa melanoma mbeva modhi uye kurapa mbeva nePD-1 uye CTLA4 tumor immunotherapy kuongorora kusimba kwesimba rekudzivirira kwechirwere chegomarara mumakonzo emazera akasiyana. Vakaona kuti nepo mapundu ari mumakonzo madiki aikwanisa kurapwa, mapundu ari mumakonzo akakura aisagona kupedzwa. Ichi chigumisiro chakabatanidzwa kune maviri anozivikanwa ezera-ane hukama hwekudzivirira hutsika: kuderedzwa kwehurongwa muhuwandu hwemasero asina maturo eT uye asina simba dendritic cell (DC) basa rekufambisa.

Masero eDendritic (DCs) anotumidzwa mazita ekufungidzira kwe dendritic anowedzera pakukura. Ivo vanoita basa rakakosha mune ese ari maviri ekuzvarwa uye anogadzirisa immune system uye ndiwo ane simba zvakanyanya antigen-anopa maseru. MaDC anokwanisa kumutsa masero eT asina ruzivo kuti atange mhinduro yezvirwere mumuviri.

Chikwata chakagadzira DC cell super-activator vaccine, iyo inogona kugadzirisa kushomeka kwemuviri mumakonzo akura.

Chidzidzo ichi chakawana kuti kushomeka kwesero kweDC kunogona kukonzeresa kushomeka kwedziviriro inocherechedzwa muhuwandu hwevanhu vakura. Nekuda kweizvozvo, vaongorori vakagadzira DC super-activator semushonga wekudzivirira. Iyi adjuvant inogona kugadzirisa kukanganisa kwekufambisa kwemasero eDC mumakonzo akwegura, kuunza cytolytic chiitiko muT mubatsiri 1 (TH1) CD4 + T masero, uye kuwedzera anti-tumor immune response mumakonzo aya akwegura.

Kudzora DC Cell Chiitiko Inodzoreredza Zera-Inoenderana Nekushaikwa Kwekudzivirirwa Kwemuviri

Mhedzisiro yezvidzidzo inoratidza kuti isu tinogona kugadzirisa kushomeka kwekudzivirira kwezera nekugadzirisa dendritic cell chiitiko, zvichiratidza kuti kushomeka kwemuviri muvanhu vakura kunodzorereka. Izvi zvine zvazvinoreva pakuvandudza hupenyu hwevakwegura uye zvinomiririra budiriro mugomarara rekudzivirira chirwere chezera iri.

Maseru eDendritic, sevarindi ve immune system, anoita basa rakakosha mukurapa cancer. Vanogona kunyatso mutsa uye kutungamira masero eT kuti azive uye aparadze cancer maseru, nekudaro vachitangisa anti-tumor immune immune mukati memuviri wemurwere.

References

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Kugadziriswa kwekuremara kwakabatana nezera mumasero edendritic kunoita kuti masero eCD4+ T abvise mapundu. Sero. 2024 Jul 25;187(15):3888-3903.e18. doi: 10.1016/j.cell.2024.05.026.

Kugadziriswa kwehurema hunoenderana nezera mumasero edendritic kunoita kuti masero eCD4+ T abvise mapundu.

Sero

IF:41.584

2024.6.12

Noulai Medical Oncology Rehabilitation Center

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Iyo Nolai Medical Oncology Rehabilitation Center inoshandisa tekinoroji yakanangwa dendritic cell (T-DC) kunyatsoona masero ebundu, kunanga uye kubvisa maseru egomarara mukati memuviri wemurwere. Iyi nzira, yakasanganiswa neCIK cell therapy, inovandudza immune system uye inogadzirisa immune system yemurwere.