Parkinsonism

Chikonzero chaicho chechirwere cheParkinson hachisati chanyatsojeka. Zvinhu zvakadai se genetic predisposition, pesvedzero yezvakatipoteredza, kuchembera, oxidative kusagadzikana, uye kupera uye kufa kwePD dopaminergic neurons inogona kuita mabasa mukuita kwechirwere.

Kuchembera

Zvose zviitiko uye kuwanda kwePD kunowedzera nezera. PD inowanzo ratidza mushure memakore makumi matanhatu, zvichiratidza kushamwaridzana nekukwegura. Dhata inoratidza kuderera kunofambira mberi mu substantia nigra dopaminergic neurons muvanhu vakuru sezvavanokura. Zvisinei, kuwanda kwePD pakati pevanhu vanopfuura 65 hakuna kunyanya kukwirira, zvichiratidza kuchembera sechimwe chezvikonzero zvinokonzera PD.

Genetic Factors

Basa rema genetic factor mukutanga kwePD iri kuwana kuzivikanwa. Kubva pakuwanikwa kwekutanga pathogenic gene yePD, alpha-synuclein (PARK1), mukupera kwema1990s, angangoita matanhatu pathogenic genes akabatanidzwa nemhuri yemhuri PD. Nekudaro, chete 5-10% yemakesi ePD ane nhoroondo yemhuri, uye mazhinji ari esporadic kesi. Genetic factor zvakare chimwe chezvikonzero zvakawanda zvinopa PD kutanga.

Zvinhu Zvakatipoteredza

Mumakore ekuma1980, vatsvakurudzi vekuAmerica vaitungamirirwa naLangston vakawana kuti vamwe vashandisi vezvinodhaka vakakurumidza kugadzira zviratidzo zvakadai seParkinson, uye levodopa yakaratidza kushanda. Vakaziva chinhu chinonzi neurotoxic, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mune yekugadzira heroin inodyiwa nevanhu ava. MPTP inoshandurwa muuropi kuita yakanyanya muchetura 1-methyl-4-phenylpyridinium ion (MPP+), iyo inosarudza kupinda dopaminergic neurons ye substantia nigra, inhibiting mitochondrial kufema kweketani yakaoma I chiitiko, ichikonzera oxidative kusagadzikana kusagadzikana, uye inotungamira mukuderera uye kufa kwe dopaminergic neurons. Vatsvakurudzi vakakurudzira kuti mitochondrial dysfunction inogona kunge iri imwe yezvikonzero zvepathogenic zvePD. Zvidzidzo zvakazotevera muvarwere vePD yekutanga zvakasimbisa kuderera kwakasarudzika mumitochondrial yekufema keteni yakaoma I basa mukati meiyo substantia nigra. Mimwe mishonga yesora nemishonga inouraya zvipembenene inogovera chimiro chemakemikari neMPTP. Kuwanikwa kweMPTP kwakatungamira pakuziva kuti mamwe makemikari akafanana neMPTP munharaunda anogona kunge ari zvinhu zvinopa PD. Nekudaro, vashoma chete vevashandisi vezvinodhaka vakafumurwa kuMPTP vakagadzira PD, zvichiratidza kuti PD inogona kukonzerwa nezvikonzero zvakawanda zvinodyidzana.

Zvimwe Zvinhu

Pamusoro pekuchembera uye genetic factor, zvinhu zvakaita sekukuvara kwehuropi, kuputa, kunwa kofi, nezvimwewo, zvinogona kuwedzera kana kuderedza njodzi yekuvandudza PD. Kusvuta kunopesana nekuitika kwePD, mhedziso inowirirana pane dzakawanda zvidzidzo. Caffeine zvakare inoratidza zvakafanana zvinodzivirira. Kukuvara kwakanyanya kwehuropi kunogona kuwedzera njodzi yekuvandudza PD.

Muchidimbu, Chirwere cheParkinson chinogona kubva mukudyidzana kweakawanda genetic uye zvakatipoteredza zvinhu.

Zviratidzo zveParkinson's Disease zvinonyanya kusanganisira:

Kudedera: Zvinowanzoitika pakuzorora, sekudedera kwemaoko panguva yekuzorora.

Muscle Rigidity: Kuomarara uye kuramba kufamba kusingafambi kunotungamira kune kushoma kufamba.

Slow Movements: Movement inononoka, uye kufamba kunova kudiki uye kudhudhudhu.

Balance Impairments: Chimiro chezvinetso zvekuenzanisa uye pfungwa yekusagadzikana.

Zvisiri-Motor Symptoms: Izvi zvinosanganisira kushushikana, kuvhiringika kwekurara, kutadza kuziva, nezvimwe.

Neurological Examination: Vanachiremba vanoongorora mamiriro ehurongwa hwetsinga kuburikidza nekuongorora kukwanisa kwemotokari yemurwere, chimiro, uye kuenzanisa.

Imaging Studies: Brain MRI kana CT scans inoshandiswa kutonga kunze kwezvimwe zvingangoitika zvinokonzera zviratidzo.

DaTscan: Nuclear mushonga scans inobatsira mukuongorora mashandiro eiyo dopamine system.

Kuongororwa kweChirwere cheParkinson kunoenderana nezviratidzo zvekiriniki uye kuongororwa kwemuviri, uye kazhinji hapana bvunzo dzakanangana dzemurabhoritari kuratidza kuongororwa. Vanachiremba vanogona kuongorora zvinoenderana nemaitiro ekuongorora ePD (seaya eUK Parkinson's Disease Society) nechinangwa chekuongorora.