Ukwelashwa
I-Advanced Neurotrophic factor therapy
Ayini amaseli omzimba?
Amaseli omzimba abhekisela eqenjini elisemzimbeni womuntu elikhethekile "ekuvikeleni." Ngokuvame ukubizwa ngokuthi amangqamuzana egazi amhlophe, amangqamuzana omzimba omzimba ahlanganisa ama-lymphocyte ahlukahlukene kanye nama-phagocyte angakwazi ukubona nokuqeda ama-antigen, abambe iqhaza ekuphenduleni komzimba. Imizimba yethu ifana nezwe elizimele, futhi amasosha omzimba asebenza njengamasosha ethu namaphoyisa. Akusebenzi nje njengebutho lezempi ukuhlonza nokuqeda amagciwane ahlaselayo kodwa futhi kusebenza njengamaphoyisa ukubona nokuqeda amaseli aguquliwe, afayo, noma ezinye izinto eziyingozi emzimbeni.
Imisebenzi yamaseli omzimba
Ukuthuthukisa Ukungavikeleki:Ukwenza kusebenze amasosha omzimba ukuthuthukisa ikhono lokulwa nokuhlasela kwegciwane kanye nama-bacteria.
Ukuthuthukisa Impilo Ekahle:Ukulawula isimiso somzimba sokuzivikela ezifweni ukuze simelane nezifo kanye namagciwane, sithuthukise amandla e-metabolic wamaselula, futhi sithuthukise ngokuphelele impilo yonke.
I-Anti-Aging:Ukuthuthukisa imetabolism, ukususa ngokushesha amaseli afile naguga ukubambezeleka ukuguga.
Ukuvimbela Nokwelashwa Komdlavuza:Ukuqinisa ikhono lomzimba lokumelana nezimila, ukusula amaseli aguquliwe ngesikhathi, ngaleyo ndlela kuvimbele futhi kuhlasele amaseli wesimila.
NK Iseli
Inani labantu elisebenzayo:Ukwenza ngcono impilo engafanele/ukuguga ngaphambi kwesikhathi; ukuvimbela ukuhlinzwa kwe-post-tumor.
Izinyathelo ezibalulekile:Idinga ukunwetshwa kwe-in vitro kwenani elikhulu lamaseli.
Izinzuzo:Ukuqaliswa okusheshayo kwezindlela zokubulala, i-spectrum ebanzi yezinhlobo zesimila.
DC Cell
Inani labantu elisebenzayo:Ukuvimbela ukuhlinzwa kwe-post-tumor.
Izinyathelo ezibalulekile:Iqoqo elivela egazini le-autologous peripheral.
Izinzuzo:Isethulo se-antigen esinamandla, ukuthwebula okunembile kwezimpawu zesimila.
Iseli ye-CAR-T
Inani labantu elisebenzayo:Izimila ze-Hematologic, izimila ezithile eziqinile.
Izinyathelo ezibalulekile:Iqoqo elivela egazini le-autologous peripheral.
Izinzuzo:Ukuhlonza okunembile kwamaseli e-tumor, anenkumbulo.
Kuseli
Inani labantu elisebenzayo: Ukuvimbela ukuhlinzwa kwe-post-tumor.
Izinyathelo Ezibalulekile: Ukuthola kuzicubu ze-autologous tumor.
Izinzuzo: Ikhono elinamandla lokubulala, ukungena kalula kwe-tumor microenvironment.
Izimo Zokusebenza Zamangqamuzana Amasosha omzimba
Ukuphumelela kwe-Neurotrophic factor therapy kunikeza inani elibonakalayo kumaseli omzimba.
Ikesi Lokuqala:
Ukuhlola komtholampilo kubonisa ukuthi iziguli zomdlavuza wamaphaphu ezifika sekwephuzile, ngemva kokwelashwa kwe-NK cell, zazuza ukulawulwa kwezifo okuzinzile. Imiphumela yokuhlola ifakazela ukuthi i-NK cell immunotherapy ingasetshenziswa njengokwelashwa kwe-adjuvant ekwelapheni iziguli ezinomdlavuza wamaphaphu osekudlule isikhathi.
Isendlalelo Sokulinga: Inhloso bekuwukuhlola ukusebenza ngempumelelo kwe-NK (HANK) cell immunotherapy eyenziwe yasebenza kakhulu ezigulini ezinomdlavuza wamaphaphu osekugcineni. Iziguli eziyishumi nantathu (abesilisa abangu-8, abesifazane abangu-5) abaneminyaka yobudala ephakathi kweminyaka engu-57.3, abatholakala bene-adenocarcinoma (n=12) noma i-squamous cell carcinoma (n=1), bafakiwe. Izigaba IV, III, kanye no-II zitholwe ku-10, 2, nesiguli esingu-1, ngokulandelanayo. Amaseli e-mononuclear ahlukaniswa ezigulini, futhi amaseli e-NK anwetshwa.
Ukusetshenziswa: Isiguli ngasinye sithole okungenani isifundo esisodwa (isifundo ngasinye sasihlanganisa ukumnika okuthathu, ukumnika ngakunye kuhlala phakathi nemizuzu engama-30). Ukwelashwa kwanyanga zonke akuzange kudlule izifundo ezintathu. Isifundo ngasinye sasihilela ukucwiliswa okulandelanayo okuthathu, okuhlala izinsuku ezintathu (cishe amaseli angu-3-5 × 10 ^ 9 HANK aqoqwe esikhwameni sokumpontshelwa igazi usuku nosuku, nge-infusion concentration ye-2 × 10 ^ 7/mL). I-Lymphocyte subsets, ukukhiqizwa kwe-cytokine, kanye nokuvezwa kwe-carcinoembryonic antigen (CEA) kanye ne-thymidine kinase 1 (TK1) yalinganiswa ngaphambi kokwelashwa nangemva kokufakwa kokugcina.
Imiphumela: Ayikho imiphumela emibi ebonwe. Ngemva kokulandelwa kwezinyanga ezingu-3, izilinganiso zeziguli ezinezifo ezizinzile neziqhubekayo zazingama-84.6% no-15.4%, ngokulandelana. Ukwengeza, amazinga e-IFN-γ anda kakhulu ngemva kokwelashwa, futhi amazinga e-CEA ehla kakhulu. Umsebenzi wokuzivikela komzimba wonke weziguli ezithola ukwelashwa kwe-NK cell wahlala uzinzile.
NgoNovemba 1984, uLinda Taylor, owesifazane wase-US Navy wesifazane one-melanoma ethuthukisiwe, wabamba iqhaza ocwaningweni lomtholampilo lwe-tumor immunotherapy olwaluholwa uDkt. Steven Rosenberg we-National Cancer Institute (NCI). Wasinda ngempumelelo futhi waba isiguli sokuqala emhlabeni elashwa nge-Neurotrophic factor therapy.
Ngo-2012, u-Emily Whitehead oneminyaka engu-6 ubudala waba ingane yokuqala emhlabeni ukuthola ukwelashwa kwamangqamuzana okuhlola. Ubambe iqhaza ocwaningweni lwaseNyuvesi yasePennsylvania ngokwelashwa kwe-CAR-T kwe-acute lymphoblastic leukemia ebuntwaneni futhi waphinde waphila impilo entsha, ephila impilo enempilo kuze kube namuhla.
Ngomhla zi-5 kuMbasa, i-2016, uhlelo lwe-CCTV-10 oluthi "Amaseli e-NK Avuselelwe" abike ukuthi uNksz Tang, oneminyaka engu-58 ubudala ngaleso sikhathi, wathola amandla athuthukisiwe kanye nokuzivikela okuthuthukisiwe ngokumpontshelwa kwe-NK cell, eqeda isimo sakhe sezempilo esingaphansi.
Ngemva kwamashumi eminyaka emizamo engapheli kanye nocwaningo olusebenzayo lwezizukulwane eziningi zososayensi, ukuqonda kwethu indima yamangqamuzana okuzivikela komzimba kanye nokuhlola ukubaluleka komtholampilo kwamangqamuzana okuzivikela komzimba ngokuqhubekayo kunika amandla amangqamuzana omzimba ukuthi adlale indima eyengeziwe.
Sikholelwa ukuthi njengoba ucwaningo kanye nokusetshenziswa kwamaseli omzimba kuqhubeka nokujula, amangqamuzana omzimba, njengabaqaphi bempilo yomuntu, azoba negalelo ekuthuthukisweni kwekhwalithi ephezulu yemizamo yempilo yabantu.