Comprehensive Lupus Management

Zomwe zimayambitsa SLE sizikudziwika, koma kugwirizana pakati pa majini ndi chilengedwe kumakhulupirira kuti kumagwira ntchito yofunika kwambiri. Kuyambitsa kwamphamvu kwa chitetezo chamthupi kumabweretsa kuukira kwa autoimmune, zomwe zimapangitsa kuwonongeka kwa minofu ndi ziwalo za thupi.

Genetic Factors:SLE imakonda kuthamanga m'mabanja, ndipo achibale a odwala amakhala ndi zochitika zambiri poyerekeza ndi anthu ambiri. Zomwe zimachitika m'mapasa ofanana ndizokwera kwambiri kuposa mapasa apachibale, kusonyeza mgwirizano pakati pa SLE ndi majini.

Zachilengedwe:
Kuwala kwa Dzuwa: Odwala a SLE nthawi zambiri amadwala matenda akakhala padzuwa, mwina chifukwa cha ultraviolet-induced cell apoptosis yomwe imatsogolera ku antigen.

Mankhwala ndi Mankhwala Othandizira: Ma antigen akunja amatha kuyambitsa chitetezo chamthupi, zomwe zimapangitsa kuti ma autoantibody apangidwe komanso kuwonongeka kwa minofu. Mankhwala monga procainamide, hydralazine, quinidine, ndi ena angapangitse SLE.
Matenda: Tizilombo toyambitsa matenda (monga cytomegalovirus, kachilombo ka hepatitis C, kachilombo ka Epstein-Barr, ndi zina zotero) zimagwira ntchito mofanana ndi mankhwala osokoneza bongo, omwe nthawi zambiri amayambitsa kupanga autoantibodies ndi chitetezo cha mthupi.

Estrogen: Mitundu yambiri ya SLE imapezeka kwambiri mwa amayi a msinkhu wobereka. Mimba ndi kugwiritsa ntchito mankhwala omwe ali ndi estrogen (monga kulera) kungapangitse matendawa. Kuyesera kwa zinyama kwasonyeza kuti estrogen imachulukitsa lupus mu zinyama zomwe zakhudzidwa, pamene testosterone imachepetsa zizindikiro, kutanthauza kuti pali mgwirizano wapakati pakati pa ma estrogen ndi kuyamba kwa SLE.

Mawonetseredwe azachipatala a SLE ndi osiyanasiyana ndipo amaphatikizapo, koma samangokhalira ku:

Zizindikiro zapakhungu: zotupa, totupa kumaso ngati gulugufe (malar rash), photosensitivity, etc.

Zizindikiro za Mgwirizano: Matenda a nyamakazi, kupweteka m’malo olumikizirana mafupa, kutupa mafupa.

Zizindikiro za aimpso: Proteinuria, hematuria, zomwe zingayambitse nephritis.

Zizindikiro zamtima: Pericarditis, kuwonongeka kwa mtima kwa valvular.

Zizindikiro Zapakati pa Nervous System: Mutu, khunyu, kuwonongeka kwa chidziwitso.

Kuzindikira kwa SLE kumaphatikizapo njira zingapo:

Kukambirana: Dokotala amafunsa zazizindikiro zazikulu, zofananira, nthawi, matenda am'mbuyomu, chithandizo, mbiri yabanja, ndi zina zambiri.

Kuyesa Kwathupi: Kuwunika kwathunthu ndikuwunika thupi, kuphatikiza khungu, tsitsi, pakamwa, ndi mfundo, pakati pa ena.

Mayesero Oyenerera: Kuyeza magazi, kusanthula mkodzo, kufufuza zithunzithunzi, kufufuza kwa impso, ndi zina zotero. Kufufuza kwa impso kumaphatikizapo opaleshoni yaing'ono pamene kachidutswa kakang'ono ka impso kamapezeka pansi pa opaleshoni ya m'deralo kuti afufuze matenda ndi immunopathological.

Kupatula zotupa zapakhungu, kuyezetsa kwa histopathological ndi kuyezetsa magazi kumakhala umboni wodziwira matenda. Kuwunika kwa Immunopathological ndikofunikira kwambiri pakuzindikira. Positive serum autoantibodies, monga anti-nuclear antibodies (ANA), anti-dsDNA antibodies, anti-Sm antibodies, etc., ndi khalidwe. Kusintha kwa ma antibody titers kumatha kuwonetsa zochitika za matenda, ndipo odwala omwe ali ndi SLE nthawi zambiri amawonetsa kuchuluka kwa erythrocyte sedimentation. Urinalysis imatha kuwonetsa proteinuria, maselo ofiira / oyera amagazi, ndi ma cell a cell.