IYunivesithi yaseHarvard ekugqibeleni ibonakalise ubudlelwane phakathi kwekhofi kunye nempilo-ukuzisola ngokungazi kwangaphambili!

Ikofu ibe sisiselo esiyimfuneko kubantu abaninzi ukuba bahlale bephaphile kwaye bomelele. Kwiingcali zanamhlanje, kunokuthiwa amandla abo eveki avela kwikofu. Nokuba yeyokuhlala uphaphile okanye ukonwabela nje ubushushu bemagi esandleni, ikofu iye yasuka ekubeni sisiselo se-niche ukuya ekubeni yinxalenye yobomi babantu abaninzi, izifake kubomi banamhlanje.

Kodwa into onokuthi ungayazi kukuba ikofu inenye inzuzo ephawulekayo, esandula kutyhilwa zizazinzulu zeYunivesithi yaseHarvard ...

Izifundo ezininzi, kubandakanywa nezo zivela kwiYunivesithi yaseHarvard kunye namanye amaziko ophando, zibonise ukuba ikofu ineenzuzo ezininzi. Inokunciphisa umngcipheko wee-cancer ezahlukahlukeneyo, inqanda ukukhula kwe-tumor, ukunciphisa umngcipheko wokufa kwayo yonke into, ukunciphisa umngcipheko we-Alzheimer's and Parkinson's disease, ingozi ephantsi yesifo senhliziyo, inceda umzimba ukuba ulahlekelwe isisindo ngokufanelekileyo, kunye nokunciphisa umngcipheko we-gallstones; phakathi kwezinye izibonelelo.

Uluhlu olubanzi lweenzuzo ezivela kwikofu lunxulumene ngokusondeleyo namakhulu eekhompawundi ezincinci ezifumaneka kwiimbotyi zekofu. Ngokomzekelo, ikofu iqulethe i-caffeine, engumthombo ocebileyo we-antioxidants kunye ne-bioactive compounds.

Ukusela ikofu kunokunciphisa umngcipheko womhlaza wesisu kunye nomhlaza wesibindi.

IYunivesithi yaseHarvard eyaziwayo emhlabeni wonke ibonise izibonelelo zempilo yekhofi-ukusela ikofu kunokunciphisa umngcipheko womhlaza we-colorectal nge-15%, kwaye ukusela iikomityi ezimbini zekhofi ngosuku kunokunciphisa amathuba okuba nomhlaza wesibindi ngama-43%.

Kwangaxeshanye, uhlolisiso olwanikelwa ingxelo nguNjingalwazi uStephanie L. Schmit nabanye abavela kwiZiko loMhlaza eliPhakamileyo iNorris kwiYunivesithi yaseSouthern California e *Cancer Biomarkers and Prevention* liye lwenza nzulu uthando lwethu ngekofu—ikofu inokunciphisa umngcipheko wokuba nomhlaza wesisu. ngama-26%.

Olu phando luphononongo lwe-molecular epidemiology olusekwe kuluntu kumhlaza webala olwenziwa kumantla akwaSirayeli. Abaphandi baphuhlise i-questionnaire eqinisekisiweyo, enesiqingatha sobungakanani bekofu ye-5,145 yezigulane ezinomhlaza we-colorectal kunye ne-4,097 yabantu abasempilweni abangenambali yomhlaza we-colorectal.

Idatha ibonise ukuba emva kokulungelelaniswa kwezinto ezinobungozi ezaziwayo, ukusetyenziswa kwekhofi ephakathi (i-1 ukuya kwi-2 iikomityi ngosuku) kunokunciphisa umngcipheko wokuba nomhlaza we-colorectal nge-26%. Ukongeza, njengoko usetyenziso lwekofu lusanda, umngcipheko wokuba nomhlaza we-colorectal wehla kancinci, umkhwa obonakalayo kuzo zombini iikholoni kunye nomhlaza we-rectal.

Ukongeza, abaphandi kwiDana-Farber Cancer Institute bapapashe uphononongo kwi-Journal of Clinical Oncology * echaza ukuba ukusetyenziswa kwekofu rhoqo kunokunciphisa kakhulu ukuphindaphinda kwethumba kunye nokuphucula amazinga okusinda kwisigaba se-III somhlaza we-colon.

Olu phononongo lulandele iipatheni zokutya zabaguli abanomhlaza obala abangama-953 abafumana ichemotherapy kwisithuba seenyanga ezintandathu. Baye bafumanisa ukuba izigulane ezidla iikomityi ezine okanye ngaphezulu zekofu ngosuku (ezinomxholo we-caffeine malunga ne-460 milligrams) zine-42% yengozi ephantsi yokuphindaphinda umhlaza xa kuthelekiswa nabangazange basele ikofu. Ngexesha lokulandelelana, izigulane ezihlala zisela iikomityi ezine okanye ngaphezulu zekofu zine-33% yengozi ephantsi yokufa ngumhlaza okanye nayiphi na enye imbangela xa kuthelekiswa nabantu abangenayo ikofu.

Uhlalutyo olongezelelweyo lubonise ukuba umngcipheko oncitshisiweyo womhlaza wawubangelwa yi-caffeine efunnwe zizigulana, kunokuba ubuninzi bamanye amacandelo ekofu.

Iziphumo ze-insulin zinokuthi zitshintshwe yikofu kwixesha elizayo.

Isifo seswekile ngoku sesona sifo sixhaphakileyo kwihlabathi liphela, sinabantu abangaphezu kwezigidi ezingama-380 abanesifo seswekile kwihlabathi liphela. Nyaka ngamnye, phantse abantu abangama-80,000 babulawa sisifo sentliziyo kunye nezinye iingxaki ezinxulumene nesifo seswekile.

Kwizigulane ezinohlobo loku-1 kunye nohlobo lwe-2 yeswekile, ukutofa i-insulin yinxalenye ebalulekileyo yobomi babo bemihla ngemihla. Nangona kunjalo, ngelixa iinaliti ze-insulin ziyindlela yonyango esebenzayo, ayifezekanga. Iinaliti ze-insulin zemihla ngemihla azinzima nje kuphela kodwa zikwalula ukuzilibala.

Amaqela ophando afumene ukuba uhlobo lweeseli zezintso lunokuvelisa i-insulin xa lubhaqa i-caffeine egazini. Emva koko, baye benza iimvavanyo kwiigundane ezilishumi zesifo seswekile, kwaye xa iigundane zisela ikofu, ukukwazi kwabo ukulawula amanqanaba e-glucose yegazi kwakungcono kuneempuku eziqhelekileyo!

Iqela lophando lathi iiseli zezintso ezifanayo zikho emzimbeni womntu, kwaye indlela ethile yokuvelisa i-insulin isafuna uphando olongezelelweyo.

Enyanisweni, ezi ziphumo zovavanyo azinasiseko. Uphononongo olwenziwa yiYunivesithi yaseHarvard olubandakanya abathathi-nxaxheba be-126,000 lubonise ukuba abaphuza ikofu rhoqo banomngcipheko omncinci wokuphuhlisa uhlobo lwe-2 yeswekile.

Olu phando luzise ithemba kwizigulane ezininzi zeswekile; mhlawumbi kwixesha elizayo, abaguli besifo seswekile baya kukwazi nje ukonwabela ikomityi yekofu ukukhuthaza ukuveliswa kwe-insulin, ukuphelisa imfuneko yeenaliti ezongezelelweyo!

**Ikofu inokuthintela ukukhula koMhlaza wamabele**

Abaphandi kwiSibhedlele seYunivesithi yaseSkåne e-UK bapapashe iziphumo kwi-*Clinical Cancer Research*, bebonisa ukuba kwabasetyhini abafunyaniswe benomhlaza webele abafumana unyango nge-tamoxifen, ukusela ikofu kunokuthintela ukukhula kwethumba kwaye kunciphise umngcipheko wokuphinda ukhule.

Uphononongo lujolise kwizigulana ze-1,090 eSweden ezifunyanwe zinomhlaza webele ohlaselayo, ngokuyintloko ukuvavanya ubudlelwane phakathi kwezinto ezimbini ezifumaneka kwikofu yaseSweden-icaffeine kunye ne-caffeic acid-kunye neempawu ze-tumor kunye nokusinda okungenasifo.

Iziphumo zabonisa ukuba phakathi kwabasetyhini abangama-500 abafumana unyango lwe-tamoxifen, abo basela ubuncinane iikomityi ezimbini zekofu ngosuku babenomngcipheko wokuphinda ubuyele umhlaza webele owawusisiqingatha sabasetyhini abasela iikomityi ezimbini okanye ngaphantsi, okanye abangaseli ikofu kwaphela. . Ukongeza, aba basetyhini babenamathumba amancinci kunye nesiganeko esisezantsi samathumba axhomekeke kwihomoni.

Abaphandi bakholelwa ukuba i-caffeine kunye ne-caffeic acid inokukhokelela ekuqhubeni komjikelo weseli kunye nokuphucula ukufa kweeseli, oko komeleza iziphumo zonyango lwe-tamoxifen.

Ikofu isempilweni ngokwenene, kodwa eyona nto iphambili ayikokongeza iswekile.

Kubalulekile ukuba uqaphele ukuba akuyiyo yonke ikofu ephilileyo; ikofu ekubhekiselwe kuyo kweli nqaku yikofu emnyama engenazo izongezo.

Okwangoku, iikofu ezininzi ezikhawulezayo okanye iikofu ezikhethiweyo kwiimarike ziqulethe inani elikhulu leswekile emhlophe kunye ne-non-dairy creamers, ezenza zibe zikhetho ezingenampilo. Ukongeza, ezo "ziselo ze-caffeinated" zineemfumba zekhrimu etyumkileyo kunye nencasa kakhulu (kubandakanywa neti yobisi) azinayo nje iikhalori ezigqithisileyo kodwa zinokubangela imiba eyahlukeneyo yempilo ngenxa yeswekile ephezulu, ngoko ke kungcono ukuzisebenzisa kancinci.

Ukuba ufumana ikofu emnyama ikrakra kakhulu, unokongeza ubisi oluncinci okanye ubisi olungumgubo.

Kukwafanelekile ukukhankanya ukuba ngelixa okwangoku akukho sithintelo kubasetyhini abakhulelweyo ukusela ikofu, kunye ne-caffeine ecetyiswayo yemihla ngemihla yokutya ayikho ngaphezu kwe-200 milligrams, uphando malunga nesi sihloko luhlala lungagqibekanga. Ngoko ke, kukhuselekile ukunciphisa ukusetyenziswa kwekofu ngexesha lokukhulelwa.

Isishwankathelo

Ngexesha lokunyangwa komhlaza, bobabini oogqirha kunye nezigulane bahlala bebeka iliso kwinkqubela phambili yesifo kwaye bafune ngenkuthalo izicwangciso ezisebenzayo zokwandisa ukusinda. Ukwanda, uphando lwezifundo lubonisa ukuba, ukongeza kwiindlela zemveli ezifana notyando, iradiotherapy, kunye nechemotherapy, ukudibanisa i-immunotherapy kunokunceda ukubuyisela imisebenzi yomzimba, ukunciphisa ukuphindaphinda, kunye nokuthintela i-metastasis.

Kakade ke, unyango lwenzululwazi nonyango olusengqiqweni lunokuzidambisa ngokufanelekileyo iimpawu, luphucule imeko yomzimba, luthobe i-cachexia, lwandise ukuphila, luze lukhuthaze ukuchacha komhlaza.

Ukongeza ekufumaneni unyango, izigulana ezinomhlaza kufuneka ziphucule ukuqonda kwazo unyango kunye nokubuyiselwa kwisimo sangaphambili ngokusebenzisa izixhobo zemfundo, zigcine unxibelelwano oluvulekileyo noogqirha bazo, kwaye zifumane indlela yokubuyisela esebenzayo ebafaneleyo. Ngoncedo lohlengahlengiso lokutya kunye neendlela zokuphucula iiseli, banokusebenzela ukubuyela kwindlela yokuphila esempilweni ngokukhawuleza!