Ithemba elitsha leZigulana zoMhlaza: Iqela laseHarvard Liphuhlisa i-DC Super-Activator Vaccine

Intshayelelo

Njengoko sikhula, umsebenzi wokuzikhusela komzimba uyehla ngokuthe ngcembe, nto leyo eyenza ukuba ube sesichengeni ngakumbi kusulelo ziintsholongwane kunye neebhaktheriya, ngelixa iziganeko zomhlaza zonyuka kakhulu. Uphando lufumanise ukuba ngaphezulu kwesibini kwisithathu somhlaza osanda kufunyaniswa uvela kubantu abaneminyaka engama-60 nangaphezulu. Oku kubonisa ubudlelwane obusondeleyo phakathi kokugonywa kunye nokuguga. Ukuba sinokuphucula amajoni omzimba kubantu abadala, kuya kuba nefuthe elihle kwimpilo yabo yonke.

NgoJuni 12, 2024, iqela likaNjingalwazi Jonathan C. Kagan waseHarvard Medical School lapapasha iphepha elinesihloko esithi "Ukulungiswa kweziphene ezinxulumene nobudala kwiiseli zedendritic zenza ukuba ii-CD4+ T cells zikwazi ukuphelisa amathumba" kwijenali *Cell*. Eli nqaku libonisa ukuba ngokungenelela kumsebenzi weeseli ze-dendritic, kunokwenzeka ukulungisa ukusilela kwe-immune yobudala, ngaloo ndlela kuphuculwe amandla e-CD4 + T cells ukuphelisa izicubu. Oku kubonelela ngendlela entsha yonyango lomhlaza kubantu abadala.

Ukuphonononga iMpembelelo yeminyaka yobudala ngokuSebenza kweCancer Immunotherapy

Iqela lophando laqala ukusebenzisa imodeli yempuku ye-melanoma kwaye baphatha iimpuku nge-PD-1 kunye ne-CTLA4 i-tumor immunotherapy ukuvavanya amandla omzimba wokulwa nomhlaza kwiimpuku zeminyaka eyahlukeneyo. Bafumanise ukuba ngelixa amathumba kwiimpuku ezincinci zinokunyangwa, amathumba kwiimpuku ezindala azinakupheliswa. Esi siphumo sidibaniswe neziphene ezimbini ezaziwayo ze-immune ezinxulumene nobudala: ukuncipha kwenkqubo kwinani leeseli ze-T ezingenalwazi kunye nobuthakathaka be-dendritic cell (DC) umsebenzi wokufuduka.

Iiseli ze-dendritic (DCs) zithiywe ngoqikelelo lwe-dendritic eziyandisayo ekuvuthweni. Zidlala indima ebalulekileyo kuzo zombini izixokelelwano zokhuselo lomzimba ezizalwa kunye neziguquguqukayo kwaye zezona zinamandla iiseli ezibonisa i-antigen. Ii-DCs ziyakwazi ukuvuselela iiseli ze-T ezingenangqondo ukuba ziqalise impendulo yokuzivikela emzimbeni.

Iqela liphuhlise isitofu sokugonya i-cell super-activator ye-DC, esinokulungisa ukusilela kwamajoni omzimba kwiimpuku ezisele zikhulile.

Uphononongo lufumanise ukuba ukusilela kokusebenza kweeseli ze-DC kunokuba sisiseko sokunqongophala kokhuselo olujongwa kubantu abadala. Ngenxa yoko, abaphandi baphuhlisa i-DC super-activator njenge-adjuvant yesitofu. Lo mncedisi unokulungisa isiphene sokufuduka kweeseli ze-DC kwiigundane ezikhulileyo, zenze umsebenzi we-cytolytic kwi-T umncedisi we-1 (TH1) we-CD4 + T, kwaye uphucule impendulo ye-anti-tumor ye-immune kula magundane amadala.

Ukulawula uMsebenzi weSeli ye-DC ubuyisela umva ukunqongophala komzimba okunxulumene nobudala

Iziphumo zophononongo zibonisa ukuba sinokulungisa ukusilela kwe-immune okunxulumene nobudala ngokulawula umsebenzi weseli ye-dendritic, sicebisa ukuba ukusilela kwe-immune kubantu asebekhulile kuya kuguqulwa. Oku kuneempembelelo ezibalulekileyo ekuphuculeni umgangatho wobomi babantu abadala kwaye kubonisa impumelelo kwi-cancer immunotherapy kweli qela leminyaka.

Iiseli ze-dendritic, njengabalindi bokhuselo lomzimba, zidlala indima ebalulekileyo kunyango lomhlaza. Banokwenza ngokufanelekileyo kwaye bakhokele iiseli ze-T ukuba ziqaphele kwaye zitshabalalise iiseli zomhlaza, ngaloo ndlela ziqalise impendulo yokulwa ne-tumor emzimbeni wesigulana.

Iimbekiselo

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Ukulungiswa kweziphene ezinxulumene neminyaka kwiiseli ze-dendritic zenza iiseli ze-CD4 + T ziphelise amathumba. Iseli. 2024 Jul 25; 187 (15): 3888-3903.e18. doi: 10.1016/j.cell.2024.05.026.

Ukulungiswa kweziphene ezinxulumene nobudala kwiiseli ze-dendritic zenza iiseli ze-CD4+ T ziphelise amathumba.

Iseli

UKUBA: 41.584

2024.6.12

Noulai Medical Oncology Rehabilitation Centre

I-Noulai Medical Oncology Rehabilitation Centre isebenzisa inkqubo ebanzi yokubuyisela umhlaza we-1 + 4 ngokusebenzisa i-immunotherapy, idibaniswe nesondlo, inkxaso yengqondo, ukulawula ubuthongo, kunye neyeza zaseTshayina. Le ndlela inceda abaguli abanomhlaza ukuba babuyisele amajoni abo omzimba, baphucule izinga labo lokuphila iminyaka emihlanu, kwaye baphucule umgangatho wobomi babo.

Ubuchwephesha obungundoqo beZiko lokuBuyiselwa kweOncology

INolai Medical Oncology Rehabilitation Centre isebenzisa ubuxhakaxhaka obujoliswe kwiseli ye-dendritic (T-DC) ukuchonga ngokuchanekileyo iiseli zethumba, ukujolisa kunye nokuphelisa iiseli zomhlaza ngaphakathi komzimba wesigulana. Le ndlela, idityaniswe nonyango lweeseli ze-CIK, iphucula ukusebenza kwamajoni omzimba kwaye ilungisa amajoni omzimba wesigulana.