I-Harvard University ekugcineni iveze ubuhlobo phakathi kwekhofi nempilo-ukuzisola ngokungazi ngaphambili!

Ikhofi seliyisiphuzo esibalulekile kubantu abaningi ukuze bahlale beqaphile futhi benamandla. Kochwepheshe besimanje, kungashiwo ukuthi amandla abo osuku lwesonto avela ekhofini. Kungakhathaliseki ukuthi elokuhlala uphapheme noma ukujabulela nje ukufudumala kwenkomishi esandleni, ikhofi selisukile ekubeni yisiphuzo se-niche laba yingxenye yezimpilo zabantu abaningi, lizigxilisa ezindleleni zokuphila zesimanje.

Kodwa ongase ukwazi ukuthi ikhofi linenye inzuzo emangalisayo, esanda kwembulwa ososayensi baseHarvard University...

Ucwaningo oluningi, kuhlanganise nalolo oluvela eNyuvesi yaseHarvard nezinye izikhungo zocwaningo, lubonise ukuthi ikhofi linezinzuzo eziningi. Inganciphisa ingozi yomdlavuza ohlukahlukene, ivimbele ukukhula kwesimila, yehlise ingozi yokufa konke, inciphise ingozi yezifo ze-Alzheimer kanye ne-Parkinson, inciphise izingozi zesifo senhliziyo nemithambo yegazi, isize umzimba wehlise isisindo ngendlela efanele, futhi yehlise nengozi yamatshe enyongo, phakathi kwezinye izinzuzo.

Uhlu olubanzi lwezinzuzo zekhofi luhlobene eduze namakhulu ezinhlanganisela ezaziwa kancane ezitholakala kubhontshisi wekhofi. Isibonelo, ikhofi iqukethe i-caffeine, engumthombo ocebile wama-antioxidants kanye nama-bioactive compounds.

Ukuphuza ikhofi kunganciphisa ingozi yomdlavuza we-colorectal kanye nomdlavuza wesibindi.

I-Harvard University eyaziwa emhlabeni wonke yake yembula izinzuzo zezempilo zekhofi-ukuphuza ikhofi kungase kunciphise ingozi yomdlavuza we-colorectal ngo-15%, futhi ukuphuza izinkomishi ezimbili zekhofi ngosuku kunganciphisa amathuba okuba nomdlavuza wesibindi ngo-43%.

Ngesikhathi esifanayo, ucwaningo olwabikwa uProfessor Stephanie L. Schmit nabanye baseNorris Comprehensive Cancer Centre eNyuvesi yaseSouthern California e *Cancer Biomarkers and Prevention* luye lwajulisa uthando lwethu ngekhofi—ikhofi linganciphisa amathuba okuba nomdlavuza wekoloni. ngo-26%.

Lolu cwaningo luwucwaningo lwe-molecular epidemiology olusekelwe kubantu ngomdlavuza we-colorectal olwenziwa enyakatho ye-Israel. Abacwaningi benze uhlu lwemibuzo oluqinisekisiwe, olulinganiselwe lokudla ikhofi ezigulini ezinomdlavuza we-colorectal kanye nabantu abangu-4,097 abanempilo abangenamlando womdlavuza we-colorectal.

Idatha iveze ukuthi ngemva kokulungiswa kwezici eziyingozi ezaziwayo, ukusetshenziswa kwekhofi okusesilinganisweni (inkomishi engu-1 kuye kwezingu-2 ngosuku) kunganciphisa ingozi yokuba nomdlavuza we-colorectal ngo-26%. Ukwengeza, njengoba ukusetshenziswa kwekhofi kwanda, ingozi yokuba nomdlavuza we-colorectal iyancipha kancane kancane, umkhuba osobala kuwo womabili umdlavuza wekholoni nowomhlane.

Ukwengeza, abacwaningi e-Dana-Farber Cancer Institute bashicilele ucwaningo ku-*Journal of Clinical Oncology* oluthi ukuphuza ikhofi okuvamile kunganciphisa kakhulu ukuphindaphinda kwesimila futhi kuthuthukise amazinga okusinda ezigulini ezinomdlavuza we-colon wesigaba sesi-III.

Lolu cwaningo lulandele amaphethini okudla eziguli ezinomdlavuza we-colorectal ezingama-953 ezilashwa ngamakhemikhali esikhathini esiyizinyanga eziyisithupha. Bathole ukuthi iziguli ezidla izinkomishi ezine noma ngaphezulu zekhofi ngosuku (ezinokuqukethwe kwe-caffeine cishe ama-milligrams angu-460) zinengozi ephansi engu-42% yokuphinda iphinde ibe nomdlavuza uma kuqhathaniswa nalabo abangaliphuzanga ikhofi. Phakathi nenkathi yokulandelela, iziguli ezivame ukuphuza izinkomishi ezine noma ngaphezulu zekhofi zazinengozi ephansi engu-33% yokufa ngenxa yomdlavuza nanoma iyiphi enye imbangela uma kuqhathaniswa nabaphuza ikhofi.

Ukuhlaziywa okwengeziwe kubonise ukuthi ukuncipha kwengozi yomdlavuza kwabangelwa i-caffeine emuncwa iziguli, kunenani lezinye izingxenye zekhofi.

Imiphumela ye-insulin ingase ithathelwe indawo ikhofi esikhathini esizayo.

Isifo sikashukela njengamanje siyisifo esivame kakhulu emhlabeni wonke, sineziguli ezingaphezu kwezigidi ezingama-380 emhlabeni jikelele. Unyaka ngamunye, cishe abantu abangu-80,000 babulawa isifo senhliziyo nezinye izinkinga ezihlobene nesifo sikashukela.

Ezigulini ezinesifo sikashukela sohlobo 1 nohlobo 2, ukujova i-insulin kuyingxenye ebalulekile yokuphila kwazo kwansuku zonke. Nokho, nakuba imijovo ye-insulin iyindlela yokwelapha ephumelelayo, ayiphelele. Imijovo ye-insulin yansuku zonke ayinzima nje kuphela kodwa futhi kulula ukuyikhohlwa.

Amaqembu ocwaningo athole ukuthi uhlobo lwengqamuzana lezinso lungakhiqiza i-insulin uma luthola i-caffeine egazini. Kamuva, benza izivivinyo kumagundane ayishumi esifo sikashukela, kwathi lapho amagundane edla ikhofi, amandla awo okulawula amazinga eglucose egazi ayengcono kunalawo amagundane avamile!

Ithimba labacwaningi lithe amaseli ezinso afanayo akhona emzimbeni womuntu, futhi indlela ethile yokukhiqiza i-insulin isadinga uphenyo olwengeziwe.

Eqinisweni, le miphumela yokuhlola ayinasisekelo. Ucwaningo olwenziwa yi-Harvard University olubandakanya ababambiqhaza abangu-126,000 lubonise ukuthi abaphuza ikhofi abavamile banamathuba amancane okuba nesifo sikashukela sohlobo lwesibili.

Lolu cwaningo lulethe ithemba ezigulini eziningi ezinesifo sikashukela; mhlawumbe esikhathini esizayo, iziguli ezinesifo sikashukela ziyomane zikwazi ukujabulela inkomishi yekhofi ukuze zikhuthaze ukukhiqizwa kwe-insulin, ziqede isidingo sokujova okwengeziwe!

**Ikhofi Lingavimba Ukukhula Komdlavuza Webele**

Abacwaningi baseLund University's Skåne University Hospital e-UK bashicilele abakutholile kwethi *Clinical Cancer Research*, okubonisa ukuthi kwabesifazane abatholakale benomdlavuza webele abathola ukwelashwa nge-tamoxifen, ukuphuza ikhofi kungavimbela ukukhula kwesimila futhi kwehlise nengozi yokuphindelela.

Ucwaningo lugxile ezigulini eziyi-1,090 eSweden ezitholwe zinomdlavuza webele ohlaselayo oyinhloko, ngokuyinhloko ukuhlola ubudlelwano phakathi kwezinto ezimbili ezivame ukutholakala ekhofini laseSweden-i-caffeine ne-caffeic acid-kanye nezici zesimila kanye nokusinda okungenazifo.

Imiphumela yabonisa ukuthi okungenani phakathi kwabesifazane abangu-500 abathola ukwelashwa kwe-tamoxifen, labo abaphuza okungenani izinkomishi ezimbili zekhofi ngosuku babesengozini yokuphinde yenzeke umdlavuza webele owawuyingxenye yabesifazane abaphuza izinkomishi ezimbili noma ngaphansi, noma abangaliphuzi nhlobo ikhofi. . Ukwengeza, laba besifazane babenezimila ezincane kanye nezinga eliphansi lamathumba ancike ku-hormone.

Abacwaningi bakholelwa ukuthi i-caffeine ne-caffeic acid ingaholela ekuqhubekeleni phambili komjikelezo wamangqamuzana kanye nokufa kwamangqamuzana okuthuthukisiwe, ngaleyo ndlela kuqinise imiphumela yokwelashwa kwe-tamoxifen.

Ikhofi linempilo ngempela, kodwa isisekelo asikona ukufaka ushukela.

Kubalulekile ukuqaphela ukuthi akuwona wonke ikhofi enempilo; ikhofi okukhulunywa ngalo kulesi sihloko ikhofi elimnyama elingenalutho ngaphandle kwezithasiselo.

Njengamanje, amakhofi amaningi asheshayo noma amakhofi anephunga elimnandi emakethe aqukethe amanani abalulekile kashukela omhlophe kanye namakhilimu angewona obisi, okwenza kube izinketho ezingenampilo. Ukwengeza, lezo "ziphuzo ezine-caffeine" ezifakwe izinqwaba zikakhilimu ophehliwe futhi ezinoshukela ngokweqile (kuhlanganise netiye lobisi) azigcini nje ngokuba nama-calories eqile kodwa futhi zingadala izinkinga zempilo ezahlukahlukene ngenxa yokuqukethwe kwazo ushukela omningi, ngakho-ke kungcono ukuzisebenzisa kancane.

Uma uthola ikhofi elimnyama libaba kakhulu, ungafaka ubisi oluncane noma impushana yobisi.

Kuyafaneleka futhi ukubalula ukuthi nakuba okwamanje kungekho ukuvinjelwa kokuthi abesifazane abakhulelwe baphuze ikhofi, futhi ukudla okunconyiwe kwe-caffeine kwansuku zonke akukho ngaphezu kwama-milligrams angu-200, ucwaningo ngalesi sihloko luhlala lungacacile. Ngakho-ke, kuphephe kakhudlwana ukunciphisa ukusetshenziswa kwekhofi ngesikhathi sokukhulelwa.

Isifinyezo

Ngesikhathi sokwelashwa komdlavuza, bobabili odokotela neziguli baqhubeka beqapha ukuqhubeka kwesifo futhi bafune ngenkuthalo amasu asebenzayo okwandisa ukusinda. Ngokukhulayo, ucwaningo lwezimo lubonisa ukuthi, ngaphezu kwezindlela zendabuko ezifana nokuhlinzwa, i-radiotherapy, nokwelashwa ngamakhemikhali, ukuhlanganisa i-immunotherapy kungasiza ukubuyisela ukusebenza komzimba, ukunciphisa ukuphindeka, nokuvimbela ukuqubuka kwe-metastasis.

Yiqiniso, ukwelapha ngokudla okungokwesayensi nokunengqondo kungadambisa izimpawu ngokuphumelelayo, kuthuthukise isimo somzimba, kwehlise i-cachexia, kunwebe ukuphila, futhi kukhuthaze ukululama komdlavuza.

Ukwengeza ekutholeni ukwelashwa, iziguli ezinomdlavuza kufanele futhi zithuthukise ukuqonda kwazo ukwelashwa nokuvuselelwa ngezinsiza zemfundo, zigcine ukuxhumana okuvulekile nodokotela bazo, futhi zithole indlela yokululama engokoqobo ebafanele. Ngosizo lokulungiswa kokudla kanye nezindlela zokuthuthukisa amaselula, bangasebenzela ukubuyela endleleni yokuphila enempilo ngokushesha okukhulu!