Ithemba Elisha Ngeziguli Zomdlavuza: Ithimba LaseHarvard Lenza Umuthi Wokugomela I-DC Super-Activator

Isingeniso

Njengoba sikhula, amasosha omzimba ayancipha kancane kancane, okwenza kube lula ukungenwa amagciwane namagciwane, kuyilapho izinga lomdlavuza landa kakhulu. Ucwaningo luthole ukuthi ngaphezu kwezingxenye ezimbili kwezintathu zomdlavuza osanda kutholwa kwenzeka kubantu abaneminyaka engama-60 nangaphezulu. Lokhu kubonisa ubudlelwano obuseduze phakathi kokuzivikela komzimba nokuguga. Uma singathuthukisa amasosha omzimba kubantu asebekhulile, kuzoba nomthelela omuhle empilweni yabo yonke.

Ngomhla ziyi-12 kuJuni 2024, ithimba likaSolwazi Jonathan C. Kagan wase-Harvard Medical School lashicilela iphepha elinesihloko esithi "Ukulungiswa kokukhubazeka okuhlobene nobudala kumaseli e-dendritic kwenza amaseli e-CD4+ T akwazi ukuqeda izimila" kujenali *Cell*. Lesi sihloko sibonisa ukuthi ngokungenelela emsebenzini wamangqamuzana e-dendritic, kungenzeka ukulungisa ukukhubazeka okuhlobene neminyaka yobudala, ngaleyo ndlela kuthuthukise ikhono lamaseli e-CD4 + T ukuqeda izimila. Lokhu kunikeza indlela entsha yokwelashwa komdlavuza kubantu asebekhulile.

Ukuhlola Umthelela Weminyaka Ekusebenzeni Kwe-Cancer Immunotherapy

Ithimba labacwaningi liqale lasebenzisa imodeli yegundane le-melanoma futhi laphatha amagundane nge-PD-1 kanye ne-CTLA4 tumor immunotherapy ukuze lihlole amandla wamasosha omzimba okulwa nomdlavuza kumagundane obudala obuhlukahlukene. Bathole ukuthi nakuba izimila zamagundane amancane zingelapheka, izimila zamagundane amadala azikwazanga ukuqedwa. Lo mphumela wawuxhunyaniswe nokusilela komzimba okuhlobene nobudala okubili okwaziwayo: ukuncishiswa kwesistimu enanini lamaseli e-T angenalutho kanye nomsebenzi wokufuduka owenziwe buthaka we-dendritic cell (DC).

Amaseli e-Dendritic (DCs) aqanjwe ngokuqagela kwe-dendritic awanwebeka lapho evuthwa. Adlala indima ebalulekile kuwo womabili amasosha omzimba azalwa nawo futhi aguquguqukayo futhi angamaseli anamandla kakhulu aveza i-antigen. Ama-DC ayakwazi ukuvuselela amaseli e-T angenangqondo ukuze aqale ukusabela komzimba emzimbeni.

Ithimba lenze umuthi wokugomela i-DC cell super-activator, ongalungisa ukushoda kwamasosha omzimba kumagundane asebekhulile.

Ucwaningo luthole ukuthi ukuntuleka kokusebenza kwamaseli e-DC kungase kube ngaphansi kokuntuleka kokuzivikela kosokhaya okubonwa kubantu asebekhulile. Ngenxa yalokho, abacwaningi bakha i-DC super-activator njenge-adjuvant yokugoma. Lesi sithasiselo singalungisa iphutha lokufuduka kwamaseli e-DC kumagundane asebekhulile, senze umsebenzi we-cytolytic kumaseli we-T umsizi 1 (TH1) e-CD4+ T, futhi sithuthukise ukusabela kwamasosha omzimba alwa nesimila kulawa magundane amadala.

Ukulawula Umsebenzi Weseli Ye-DC Kuhlehlisa Ukuntula Amasosha omzimba Okuhlobene Neminyaka

Imiphumela yocwaningo ikhombisa ukuthi singalungisa ukuntula kwamasosha omzimba okuhlobene neminyaka ngokuphatha umsebenzi wamaseli e-dendritic, iphakamisa ukuthi ukusilela kwamasosha omzimba kubantu asebekhulile kungabuyiselwa emuva. Lokhu kunemithelela ebalulekile ekwenzeni ngcono izinga lempilo yabantu asebekhulile futhi kumelela impumelelo ekwelashweni komdlavuza kuleli qembu lobudala.

Amaseli e-dendritic, njengabalindi bamasosha omzimba, adlala indima ebalulekile ekwelashweni komdlavuza. Angakwazi ukwenza kusebenze futhi aqondise amaseli e-T ngempumelelo ukuze abone futhi abhubhise amangqamuzana omdlavuza, ngaleyo ndlela aqalise impendulo yokulwa nethumba emzimbeni wesiguli.

Izithenjwa

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Ukulungiswa kweziphambeko ezihlobene nobudala kumaseli e-dendritic kwenza amaseli e-CD4+ T akwazi ukuqeda izimila. Iseli. 2024 Jul 25;187(15):3888-3903.e18. doi: 10.1016/j.cell.2024.05.026.

Ukulungiswa kokukhubazeka okuhlobene neminyaka kumaseli e-dendritic kwenza amaseli e-CD4+ T akwazi ukuqeda izimila

Iseli

IF:41.584

2024.6.12

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