Chiyembekezo Chatsopano cha Odwala Khansa: Gulu la Harvard Lipanga Katemera wa DC Super-Activator

Mawu Oyamba

Tikamakalamba, chitetezo cha mthupi chimachepa pang'onopang'ono, zomwe zimapangitsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda, tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda, tizilombo toyambitsa matenda, tizilombo toyambitsa matenda, tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda. Kafukufuku wapeza kuti magawo awiri mwa atatu aliwonse a khansa omwe angopezeka kumene amapezeka mwa anthu azaka 60 ndi kupitilira apo. Izi zikuwonetsa kugwirizana kwapakati pakati pa chitetezo chokwanira ndi ukalamba. Ngati titha kupititsa patsogolo chitetezo cha mthupi mwa anthu okalamba, zidzakhala ndi zotsatira zabwino pa thanzi lawo lonse.

Pa June 12, 2024, gulu la Professor Jonathan C. Kagan la ku Harvard Medical School linasindikiza pepala lotchedwa "Kuwongolera zolakwika zomwe zimayenderana ndi zaka m'maselo a dendritic kumathandiza kuti CD4+ T maselo athetse zotupa" mu magazini ya *Cell*. Nkhaniyi ikuwonetsa kuti polowererapo pa ntchito ya maselo a dendritic, n'zotheka kukonza zofooka za chitetezo cha m'thupi zokhudzana ndi zaka, motero kumapangitsa kuti maselo a CD4 + T athetse zotupa. Izi zimapereka njira yatsopano yothandizira khansa kwa okalamba.

Kuwona Zokhudza Ukalamba pa Kuchita Bwino kwa Khansa Immunotherapy

Gulu lofufuzalo lidagwiritsa ntchito koyamba mbewa ya melanoma ndikuchiritsa mbewazo ndi PD-1 ndi CTLA4 chotupa cha immunotherapy kuti awone mphamvu ya chitetezo chamthupi cholimbana ndi khansa mu mbewa zazaka zosiyanasiyana. Iwo adapeza kuti ngakhale zotupa za mbewa zazing'ono zimatha kuchiritsidwa, zotupa za mbewa zakale sizingathe kuthetsedwa. Chotsatirachi chinali cholumikizidwa ndi zofooka ziwiri zodziwika bwino zokhudzana ndi zaka: kuchepa kwadongosolo kwa chiwerengero cha maselo a T osazindikira komanso kufooka kwa ntchito ya dendritic cell (DC).

Maselo a dendritic (DCs) amatchulidwa chifukwa cha dendritic projekiti yomwe amakulitsa akakhwima. Amagwira ntchito yofunika kwambiri m'maselo obadwa nawo komanso osinthika ndipo ndi maselo amphamvu kwambiri omwe amawonetsa antigen. Ma DC amatha kulimbikitsa ma cell a T osazindikira kuti ayambitse chitetezo chamthupi m'thupi.

Gululo linapanga katemera wa DC cell super-activator, yemwe amatha kukonza zofooka za chitetezo cha mthupi mwa mbewa zachikulire.

Kafukufukuyu adapeza kuti kuchepa kwa magwiridwe antchito a ma cell a DC kungayambitse kusowa kwa chitetezo cha omwe akuwonedwa mwa okalamba. Chifukwa chake, ofufuzawo adapanga DC super-activator ngati chothandizira katemera. Wothandizira uyu amatha kukonza kusamuka kwa ma cell a DC mu mbewa okalamba, kuyambitsa ntchito ya cytolytic mu T wothandizira 1 (TH1) CD4 + T ma cell, ndikuwonjezera kuyankha kwa anti-chotupa mu mbewa zakalezi.

Kuwongolera Zochita Zama cell a DC Kumachepetsa Kuperewera kwa Chitetezo cha Mthupi Chokhudzana ndi Zaka

Zotsatira za kafukufukuyu zikuwonetsa kuti titha kukonza zofooka za chitetezo cham'thupi zokhudzana ndi ukalamba mwa kuwongolera zochitika zama cell a dendritic, ndikuwonetsa kuti kufooka kwa chitetezo chamthupi mwa okalamba kumasinthidwa. Izi zili ndi tanthauzo lalikulu pakuwongolera moyo wa okalamba ndipo zikuyimira kupambana kwa khansa ya immunotherapy kwa gulu lazaka izi.

Ma cell a dendritic, monga alonda a chitetezo chamthupi, amagwira ntchito yofunika kwambiri pakuchiza khansa. Amatha kuyambitsa ndikuwongolera maselo a T kuti azindikire ndikuwononga maselo a khansa, potero kuyambitsa kuyankha kwa anti-chotupa m'thupi la wodwalayo.

Maumboni

Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Kuwongolera zolakwika zokhudzana ndi zaka m'maselo a dendritic kumathandiza maselo a CD4 + T kuthetsa zotupa. Selo. 2024 Jul 25; 187 (15): 3888-3903.e18. doi: 10.1016/j.cell.2024.05.026.

Kuwongolera zolakwika zokhudzana ndi zaka m'maselo a dendritic kumathandizira ma CD4 + T kuti athetse zotupa.

Selo

IFE: 41.584

2024.6.12

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