Ulawulo lweLupus oluBanzi

Oyena nobangela we-SLE awucacanga, kodwa intsebenziswano phakathi kofuzo kunye nezinto ezisingqongileyo kukholelwa ukuba idlala indima ebalulekileyo. Ukusebenza ngokungaqhelekanga kwesistim somzimba sokuzivikela kukhokelela ekuhlaselweni kwe-autoimmune, okukhokelela kumonakalo kwizicubu zomzimba kunye namalungu.

Imiba yemfuzo:I-SLE idla ngokuqhuba kwiintsapho, kwaye izalamane zezigulane zineziganeko eziphezulu kakhulu xa kuthelekiswa noluntu ngokubanzi. Ukwenzeka kwamawele afanayo kuphezulu kakhulu kunamawele azalwa kunye, ebonisa ubudlelwane phakathi kwe-SLE kunye nezinto zofuzo.

Imiba yokusingqongileyo:
Ukukhanya kwelanga: Izigulana ze-SLE zihlala zifumana ukuvutha kwesifo emva kokuvela kwelanga, mhlawumbi ngenxa ye-ultraviolet-induced cell apoptosis ekhokelela ekuvezweni kwe-antigen.

Iziyobisi kunye neeAgents zeMichiza: Ama-antigens angaphandle angenza amajoni omzimba asebenze, okubangela ukuveliswa kwe-autoantibody kunye nomonakalo wezicubu. Iziyobisi ezifana neprocainamide, hydralazine, quinidine, kunye nezinye zinokubangela i-SLE.
Usulelo: Iintsholongwane ze-Pathogenic (ezifana ne-cytomegalovirus, i-virus ye-hepatitis C, i-virus ye-Epstein-Barr, njl.) yenza ngokufanayo namachiza, ngokuqhelekileyo ibangela ukuveliswa kwe-autoantibodies yi-immune system.

I-Estrogen: Uninzi lweentlobo ze-SLE zixhaphake kakhulu kubasetyhini abakwiminyaka yokuzala. Ukukhulelwa kunye nokusetyenziswa kweziyobisi eziqukethe i-estrogen (ezifana nezithintelo zokukhulelwa) kunokunyusa isifo. Uvavanyo lwezilwanyana lubonise ukuba i-estrogen iyandisa i-lupus kwizilwanyana ezichaphazelekayo, ngelixa i-testosterone inciphisa iimpawu, iphakamisa ukuhambelana okusondeleyo phakathi kwamanqanaba e-estrogen kunye nokuqala kwe-SLE.

Ukubonakaliswa kweklinikhi ye-SLE kwahluka kwaye kubandakanya, kodwa akuphelelanga koku:

Iimpawu zeLusu: I-Rashes, i-butterfly-shaped face rash (i-malar rash), i-photosensitivity, njl.

Iimpawu ezidibeneyo: I-arthritis, intlungu edibeneyo, ukudumba kwamalungu.

Iimpawu zezintso: Iproteinuria, i-hematuria, enokukhokelela kwi-nephritis.

Iimpawu ze-Cardiac: I-Pericarditis, umonakalo wentliziyo ye-valvular.

Iimpawu zeSistim yeNervous ephakathi: Intloko, ukuxhuzula, ukuphazamiseka kwengqondo.

Ukuxilongwa kwe-SLE kubandakanya amanyathelo amaninzi:

Ukubonisana: Ugqirha ubuza malunga neempawu eziphambili, iimpawu ezinxulumene nazo, ubude bexesha, ukuxilongwa kwangaphambili, unyango, imbali yosapho, njl.

Uvavanyo loMzimba: Uvavanyo olubanzi kunye novavanyo lomzimba, kubandakanya ulusu, iinwele, umngxuma womlomo, kunye namalungu, phakathi kwabanye.

Iimvavanyo ezifanelekileyo: Uvavanyo lwegazi, uhlalutyo lomchamo, izifundo ze-imaging, i-biopsies yezintso, njl njl. I-biopsies yezintso ibandakanya inkqubo encinci yotyando apho iqhekeza elincinci lezintso lifunyanwa phantsi kwe-anesthesia yendawo yokuhlolwa kwe-pathological and immunopathological.

Ngaphandle kwezilonda eziqhelekileyo zolusu, uvavanyo lwe-histopathological kunye novavanyo lwegazi lusebenza njengobungqina bokuxilonga. Uvavanyo lwe-immunopathological lunexabiso elikhulu ekuxilongweni. Ii-autoantibodies ze-serum ezintle, ezifana ne-anti-nuclear antibodies (ANA), i-anti-dsDNA antibodies, i-anti-Sm antibodies, njl., ziyimpawu. Utshintsho kwi-antibody titers lungabonakalisa umsebenzi wesifo, kwaye izigulane ezisebenzayo ze-SLE zihlala zibonisa ukwanda kwe-erythrocyte sedimentation rate. Ukuhlaziywa kwe-Urinalysis kunokubonisa i-proteinuria, iiseli zegazi ezibomvu / ezimhlophe, kunye neeseli zeselula.