Ukuphathwa Kwe-Lupus Okuphelele

Imbangela yangempela ye-SLE ayicacile, kodwa ukusebenzisana phakathi kwezici zofuzo nezemvelo kukholakala ukuthi kunendima ebalulekile. Ukusebenza okungavamile kwamasosha omzimba kuholela ekuhlaselweni kwe-autoimmune, okuholela ekulimaleni kwezicubu nezitho zomzimba.

Izakhi zofuzo:I-SLE ijwayele ukusebenza emindenini, futhi izihlobo zeziguli zinezigameko eziphezulu kakhulu uma ziqhathaniswa nenani labantu elivamile. Ukwenzeka kumawele afanayo kuphakeme kakhulu kunakumawele angabafowabo, okubonisa ubudlelwano phakathi kwe-SLE nezici zofuzo.

Izici Zemvelo:
Ukukhanya kwelanga: Iziguli ze-SLE zivame ukuba nokuqubuka kwezifo ngemva kokuchayeka elangeni, okungenzeka ngenxa ye-apoptosis yeseli ebangelwa yi-ultraviolet eholela ekuchayekeni kwe-antigen.

Izidakamizwa kanye nama-Chemical Agents: Ama-antigen angaphandle angenza amasosha omzimba asebenze, okuholela ekukhiqizweni kwama-autoantibody kanye nokulimala kwezicubu. Izidakamizwa ezifana ne-procainamide, i-hydralazine, i-quinidine, nezinye zingadala i-SLE.
Ukutheleleka: Amagciwane e-Pathogenic (afana ne-cytomegalovirus, igciwane le-hepatitis C, igciwane le-Epstein-Barr, njll.) enza ngendlela efanayo nezidakamizwa, ngokuvamile abangela ukukhiqizwa kwama-autoantibodies amasosha omzimba.

I-Estrogen: Izinhlobo eziningi ze-SLE zivame kakhulu kwabesifazane abaneminyaka yobudala yokuzala. Ukukhulelwa kanye nokusetshenziswa kwezidakamizwa ezine-estrogen (njengemithi yokuvimbela inzalo) kungabhebhethekisa lesi sifo. Ukuhlolwa kwezilwane kuye kwabonisa ukuthi i-estrogen ibhebhethekisa i-lupus ezilwaneni ezithintekile, kuyilapho i-testosterone inciphisa izimpawu, iphakamisa ukuhlobana okuseduze phakathi kwamazinga e-estrogen kanye nokuqala kwe-SLE.

Ukubonakaliswa komtholampilo kwe-SLE kuhlukene futhi kufaka phakathi, kodwa akukhawulelwe ku:

Izimpawu Zesikhumba: Ukuqubuka, ukuqubuka kobuso okumise okwemvemvane (i-malar rash), ukuzwela kwezithombe, njll.

Izimpawu Ezihlangene: I-arthritis, ubuhlungu bamalunga, ukuvuvukala kwamalunga.

Izimpawu ze-Renal: I-Proteinuria, i-hematuria, engaholela ku-nephritis.

Izimpawu Zenhliziyo: I-Pericarditis, ukulimala kwenhliziyo ye-valvular.

Izimpawu Zesistimu Yezinzwa Emaphakathi: Ikhanda elibuhlungu, ukuquleka, ukukhubazeka kwengqondo.

Ukuxilongwa kwe-SLE kuhilela izinyathelo ezimbalwa:

Ukubonisana: Udokotela ubuza ngezimpawu ezinkulu, izimpawu ezihlobene, ubude besikhathi, ukuxilonga okudlule, ukwelashwa, umlando womndeni, njll.

Ukuhlolwa Komzimba: Ukuhlolwa okuphelele nokuhlolwa komzimba, okuhlanganisa isikhumba, izinwele, umgodi womlomo, namalunga, phakathi kokunye.

Ukuhlolwa Okubalulekile: Ukuhlolwa kwegazi, ukuhlaziya umchamo, izifundo zokuthwebula izithombe, ukuhlolwa kwezinso, njll. Ukuhlolwa kwezinso kuhilela ukuhlinzwa okuncane lapho ucezu oluncane lwezicubu zezinso lutholwa ngaphansi kwe-anesthesia yendawo ukuze kuhlolwe i-pathological and immunopathological.

Ngaphandle kwezilonda ezijwayelekile zesikhumba, ukuhlolwa kwe-histopathological kanye nokuhlolwa kwegazi kusebenza njengobufakazi bokuxilonga. Ukuhlolwa kwe-immunopathological kubaluleke kakhulu ekuxilongweni. Ama-autoantibodies e-serum positive, njengamasosha omzimba alwa nenuzi (ANA), amasosha omzimba e-dsDNA, amasosha omzimba alwa ne-Sm, njll., ayisici. Izinguquko kuma-antibody titer zingabonisa umsebenzi wesifo, futhi iziguli ezisebenzayo ze-SLE zivame ukubonisa izinga lokukhuphuka kwe-erythrocyte sedimentation. I-urinalysis ingase ibonise i-proteinuria, amangqamuzana egazi abomvu/amhlophe, kanye nokukhishwa kwamaselula.